A kind of salvianolic acid A freeze-dried powder injection and its preparation medicine use
A technology for freeze-dried powder injection and salvianolic acid, which is applied in the field of salvianolic acid A freeze-dried powder for injection and preparation of medicines
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Embodiment 1
[0114] Take Danshen medicinal materials, crush them into 6 mesh particles, add 7 times the amount of 92℃ water each time, warm soak and extract 3 times, while stirring at 25 rpm, each warm soak and extract 3 hours; the extract is concentrated under reduced pressure to relative Density 1.20 (60℃), add ethanol to make the alcohol content 70%, let stand, filter, the filtrate is decompressed to recover the ethanol and concentrated to no alcohol; dilute with water to 20mg of salvianolic acid B per 1ml, use 10% of the aqueous solution Adjust pH to 4.0 with sodium hydroxide, add 0.5% ZnCl 2 As a catalyst, heat conversion at 120°C for 4 hours. The conversion solution was adjusted to pH 2.5 with 20% phosphoric acid, centrifuged, and the supernatant was concentrated under reduced pressure to contain 3mg of salvianolic acid A per 1ml, and then subjected to HPD-100 macroporous resin column chromatography Separation, the ratio of loading amount of salvianolic acid A to the macroporous adsorp...
Embodiment 2
[0117] Take Danshen medicinal materials and crush them into granules with a diameter of about 2mm. Add 7 times the amount of water at 90℃ each time and extract 3 times with warm immersion. At the same time, they are stirred at a speed of 25 rpm. Each warm immersion is extracted for 3 hours; the extract is concentrated to The relative density is 1.18 (60℃), add ethanol to make the alcohol content 70%, let stand, filter, the filtrate is decompressed to recover the ethanol and concentrated to no alcohol; dilute with water to 20mg of salvianolic acid B per 1ml, use 10 % Sodium hydroxide adjust the pH to 5.5, add 0.5% ZnCl 2 As a catalyst, heat conversion at 120°C for 4 hours. The conversion solution was adjusted to pH 2.5 with 20% phosphoric acid, centrifuged, and the supernatant was concentrated under reduced pressure to contain 3mg of salvianolic acid A per 1ml, and then subjected to HPD-100 macroporous resin column chromatography Separation, the ratio of loading amount of salvian...
Embodiment 3
[0120] Take Danshen medicinal materials, cut into decoction pieces, add 8 times each time to 85℃ water temperature immersion extraction 3 times, while stirring at 20 rpm, each warm immersion extraction 2.5 hours; the extract is concentrated under reduced pressure to a relative density of 1.17 (60 ℃), add ethanol to make the alcohol content 75%, stand still, filter, the filtrate is decompressed to recover ethanol and concentrated to no alcohol; dilute with water to contain 15mg of salvianolic acid B per 1ml, adjust the aqueous solution with 10% potassium hydroxide pH to 5.0, add 0.6% ZnCl 2 As a catalyst, heat conversion at 120℃ for 3.5 hours. The conversion solution was adjusted to pH 2.5 with 15% hydrochloric acid, centrifuged, and the supernatant was concentrated under reduced pressure to contain 5mg of salvianolic acid A per 1ml, and then passed through HPD-100 macroporous resin column. Analyze and separate, the ratio of loading amount of salvianolic acid A to macroporous ads...
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Abstract
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