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Amoxicillin sodium sulbactam sodium for injection and preparation method of amoxicillin sodium sulbactam sodium

A technology for amoxicillin sodium and sulbactam sodium for injection, which is applied in the field of veterinary medicine, can solve problems such as inconvenience for animals to take oral administration, long time to peak, refusal to eat, anorexia, etc. good effect

Active Publication Date: 2013-06-12
HEILONGJIANG HUIFENG ANIMAL HEALTH PRODS +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, the dosage forms of amoxicillin commonly used are mainly powder and injection; powder often has food refusal and anorexia phenomenon in animals, which is not convenient for animals to take orally; injections are all oil solutions, with a long peak time and slow onset of action

Method used

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  • Amoxicillin sodium sulbactam sodium for injection and preparation method of amoxicillin sodium sulbactam sodium
  • Amoxicillin sodium sulbactam sodium for injection and preparation method of amoxicillin sodium sulbactam sodium

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Effect test

Embodiment 1

[0012] A kind of amoxicillin sodium sulbactam sodium for veterinary injection, each raw material and its parts by weight are respectively: amoxicillin sodium 2g; sulbactam sodium 1g; sodium thiosulfate 0.1g; polyethylene glycol 2000 lg ; Sodium hydroxide solution 0.2mol / L (adjusted to pH 8.5-9.5); water for injection to a sufficient amount.

[0013] (1) Preparation: Add sodium thiosulfate and polyethylene glycol 2000 to 70% of the prescribed amount of water for injection, stir until completely dissolved; add the prescribed amount of amoxicillin sodium and sulbactam sodium to the above solution , use 0.2mol / L sodium hydroxide solution to adjust the pH to 8.5-9.5, stir until amoxicillin sodium and sulbactam sodium are completely dissolved, and the solution is a clear and transparent light yellow liquid; dilute to volume with water for injection, pass through 0.22μm micropores Membrane filtration, sampling, and testing of semi-finished products; stock solution preparation time do...

Embodiment 2

[0021] __Amoxicillin sodium and sulbactam sodium for veterinary injection, each raw material and parts by weight are respectively:

[0022] _Amoxicillin sodium 2g; sulbactam sodium 0.5g; sodium sulfite 0.1g; povidone K30 0.4g; potassium hydroxide solution 0.2mol / L (adjusted to pH 8.5-9.5); water for injection to a sufficient amount.

[0023] (1) Preparation: Sodium sulfite and povidone K30 are added to 70% of the prescribed amount of water for injection, and stirred until completely dissolved; / L of potassium hydroxide to adjust the pH to 8.5-9.5, stir until the amoxicillin sodium and sulbactam sodium are completely dissolved, and the solution is a clear and transparent light yellow liquid; water for injection is fixed to volume, passed through a 0.22 μm microporous membrane, and sampled. For semi-finished product testing; stock solution preparation time does not exceed 2 hours;

[0024] (2) Calculate the volume of solution that needs to be filled in each vial according to th...

Embodiment 3

[0031] A kind of amoxicillin sodium sulbactam sodium for veterinary injection, each raw material and parts by weight thereof are respectively:

[0032] _Amoxicillin sodium 2g; sulbactam sodium 0.5g; sodium sulfite 0.1g; poloxamer 188 6g; sodium hydroxide solution 0.2mol / L (adjusted to pH 8.5-9.5); water for injection to a sufficient amount.

[0033] (1) Preparation: Add sodium sulfite and poloxamer 188 to 70% of the prescribed amount of water for injection, stir until completely dissolved; add the prescribed amount of amoxicillin sodium and sulbactam sodium to the above solution, and use 0.2 mol / L sodium hydroxide solution to adjust the pH to 8.5-9.5, stir until amoxicillin sodium sulbactam sodium is completely dissolved, and the solution is a clear and transparent light yellow liquid; water for injection is fixed to volume, passed through a 0.22 μm microporous membrane, Sampling and testing of semi-finished products; preparation time of stock solution shall not exceed 2 hours...

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Abstract

The invention relates to amoxicillin sodium sulbactam sodium for injection for livestock and a preparation method of the amoxicillin sodium sulbactam sodium. The invention aims at providing an amoxicillin sodium sulbactam sodium freeze-dried powder injection. The amoxicillin sodium sulbactam sodium freeze-dried powder injection comprises effective components of amoxicillin sodium and sulbactam sodium, and also contains an antioxygen, a pH(Potential Of Hydrogen) regulating agent and a dispersing agent, and thus the solubility of the amoxicillin sodium is greatly increased, and the pH of medicine liquid after being re-dissolved is within a range of 8.5-9.5. According to the amoxicillin sodium sulbactam sodium and the preparation method of the amoxicillin sodium sulbactam sodium, through research of the preparation of an amoxicillin sodium sulbactam sodium stock solution and determination of a freeze-drying process, the amoxicillin sodium sulbactam sodium freeze-dried powder injection which is stable in quality, better in appearance characteristics and safe and effective in use is obtained.

Description

technical field [0001] The invention belongs to the field of veterinary medicine, in particular to a preparation process of amoxicillin sodium sulbactam sodium for injection. Background technique: [0002] Amoxicillin is a broad-spectrum penicillin antibiotic. , Salmonella, Haemophilus influenzae, Neisseria gonorrhoeae and other aerobic Gram-negative bacteria that do not produce β-lactamase strains and Helicobacter pylori have good antibacterial activity. Amoxicillin exerts a bactericidal effect by inhibiting the synthesis of bacterial cell walls, and can rapidly dissolve and rupture bacteria into spheroids. Therefore, it is widely used in veterinary clinics, mainly for the treatment of animal bacterial infections. [0003] The commonly used dosage forms of amoxicillin are mainly powders and injections at present; powders often have food refusal and anorexia phenomena in animals, which is not convenient for animals to take orally; injections are all oil solutions, with a l...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/43A61K9/19A61P31/04
Inventor 蔡显玲赵风立尹建华马文杰
Owner HEILONGJIANG HUIFENG ANIMAL HEALTH PRODS
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