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Devices for Assessing Vascular Endothelial Function

A vascular endothelial, vascular technology, used in the evaluation of vascular endothelial function device, sex index and vascular field

Active Publication Date: 2017-09-08
HIROSHIMA UNIVERSITY +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It turns out that when the elasticity decreases and the viscosity increases at the same time, adequate determination cannot be performed with the measurement of the amplitude change

Method used

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  • Devices for Assessing Vascular Endothelial Function
  • Devices for Assessing Vascular Endothelial Function
  • Devices for Assessing Vascular Endothelial Function

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Experimental program
Comparison scheme
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Embodiment Construction

[0054] The inventors of the present application found that shear stress inside blood vessels caused by blood flow immediately after arterial occlusion promotes the production of vascular depressor substance NO from vascular endothelial cells, resulting in enlarged blood vessel diameters and increased blood vessel viscosity.

[0055] The relationship between the blood pressure change and the blood vessel volume pulse wave can be expressed by the following expression. According to Boyle's law,

[0056] P×V=k (constant)

[0057] where P is the in-cuff pressure of the cuff and V is the in-cuff volume.

[0058] When the vessel volume increases by ΔV, and the pressure in the cuff increases by ΔP,

[0059] (P+ΔP)×(V+ΔV)=k.

[0060] Here, ΔP×ΔV is sufficiently small so that the following formula holds:

[0061] ΔV=ΔP×(V / P).

[0062] It can be seen that under the condition of constant P and V, the pressure pulse wave ΔP is proportional to the change of blood vessel volume ΔV. The...

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Abstract

A device for assessing vascular endothelial function, the device comprising: a cuff pressure control unit configured to apply pressure to a part of a subject's body by using a cuff adapted to be wrapped around the part of the subject's body performing continuous pressure stimulation for a predetermined time; a cuff pressure detection unit configured to detect cuff pressure from an output of a pressure sensor connected to the cuff; a pulse wave detection unit configured to detect the cuff pressure from an output of the pressure sensor outputting a detection pulse wave; and an analysis unit configured to evaluate vascular endothelial function by comparing a vascular viscoelastic index not including the pulse wave amplitude from before, during, and after the pressure stimulation The pulse waves detected in the two segments after and after the segment are obtained.

Description

[0001] Cross References to Related Applications [0002] This application is based on and claims the benefit of priority from prior Japanese Patent Application No. 2011-276925 filed on December 9, 2011, the entire contents of which are hereby incorporated by reference. Background technique [0003] The subject matter disclosed in the present application relates to a device for evaluating vascular endothelial function in which an evaluation similar to that obtained in measurements using an ultrasound echo system can be obtained without using an ultrasound echo system or the like. [0004] Recent studies have shown that the degradation of vascular endothelial function is the initial stage when arteriosclerosis occurs. To prevent arteriosclerosis, techniques and devices for assessing vascular endothelial function have been developed. [0005] As a reliable technique for evaluating vascular endothelial function, there exists a device called an FMD (Flow-Mediated Dilation) measure...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61B5/02
CPCA61B5/02007A61B5/02108A61B5/02233A61B5/0225A61B5/7242A61B5/7278
Inventor 辻敏夫吉栖正生东幸仁河本昌志小泽秀夫鹈川贞二高柳恒夫森本阳香久保谅祐
Owner HIROSHIMA UNIVERSITY