Preparation method of phosphatidylcholine-biomimetic-modified polylactic acid material
A technology of polylactic acid material and phosphatidylcholine, which is applied in the field of preparation of polylactic acid material bionically modified by phosphatidylcholine, can solve the problems of strong hydrophobicity, weak cell biocompatibility, and insufficient blood compatibility
Inactive Publication Date: 2013-06-19
傅亚
View PDF2 Cites 4 Cited by
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
However, there are still some deficiencies in PLA, such as (1) the effect of acid-induced autocatalytic accelerated degradation during the degradation process (Biomedical Materials. 2000.54-55.); (2) strong hydrophobicity, no site for cell recognition point, resulting in poor cell biocompatibility (J Biomater Sci: Polymer Edn. 2001.12 (1): 107-124.); (3) when in contact with blood, the hemocompatibility of PLA is insufficient, etc. (Journalof Electroanalytical Chemistry, 2008, 621(1): 69-74.; European Journal of Pharmaceutics and Biopharmaceutics, 2005, 59(3): 375-388.)
Method used
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View moreImage
Smart Image Click on the blue labels to locate them in the text.
Smart ImageViewing Examples
Examples
Experimental program
Comparison scheme
Effect test
Embodiment Construction
[0009] 1. Synthesis of maleic anhydride-modified polylactic acid (MPLA)
[0010] Dissolve PDLLA in dichloromethane, add MA and BPO (5% of the mass of MA) in a ratio of 10%, stir well, and vacuum-dry at room temperature to constant weight; react at 100°C for 10 hours under nitrogen protection to obtain MPLA. The product was separated and purified three times with chloroform-methanol, dried in vacuo, and set aside. The weight average molecular weight of the product is Mw=5.18×10 5 .
[0011] 2. Synthesis of diamine-modified polylactic acid (DPLA)
[0012] Add 5mL of BDA in tetrahydrofuran (THF) to a three-neck flask; dissolve a certain amount of MPLA in 50mL of THF, and drop it into the flask while stirring, and control the reaction temperature below 20°C. After the dropwise addition, the temperature was raised to 37° C. for 30 minutes. BDA was added at 200% of its stoichiometric amount. After the reaction was completed, the product was dropped into excess distilled water,...
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More PUM
Login to View More Abstract
The invention relates to a preparation method of a phosphatidylcholine-biomimetic-modified polylactic acid material. Currently, when polylactic acid is adopted as a biomedical material, an acid-induced autocatalytic degradation acceleration effect still exists in a degradation process; polylactic acid hydrophobicity is high, no site is provided for cell to identify, such that cell biocompatibility is poor; and polylactic acid hemocompatibility is poor when contacting blood. The method is provided aiming at the above problems. The method mainly comprises the steps that: with a free radial polymerization reaction, maleic anhydride is grafted on a side chain of the polylactic acid; diaminobutane is subjected to a reaction with maleic anhydride; with introduced active reaction group and double-bond of 2-acryloyloxyethyl phosphatidylcholine, a Micheal addition reaction is carried out, and phosphatidylcholine biomimetic modification upon polylactic acid is realized. Compared with polylactic acid, the phosphatidylcholine-biomimetic-modified polylactic acid material provided by the invention has a substantial inhibition effect against acid-induced degradation, better cell compatibility, and good hemocompatibility.
Description
technical field [0001] The invention relates to a preparation method of a biological material with good cell compatibility and blood compatibility, in particular to a preparation method of a phosphatidylcholine biomimetic modified polylactic acid material. Background technique [0002] Polylactic acid (PLA) has good biocompatibility and biodegradability, and the final product of metabolism in the body is CO 2 and H 2 O, the intermediate product lactic acid is also a product of normal metabolism in the body, so as a biomedical material, it has been highly valued and widely studied in the fields of tissue engineering and drug controlled release. However, there are still some deficiencies in PLA, such as (1) the effect of acid-induced autocatalytic accelerated degradation during the degradation process (Biomedical Materials. 2000.54-55.); (2) strong hydrophobicity, no site for cell recognition point, resulting in poor cell biocompatibility (J Biomater Sci: Polymer Edn. 2001.1...
Claims
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More Application Information
Patent Timeline
Login to View More IPC IPC(8): C08G63/91C08G63/08C08G63/78C08L67/04
Inventor 傅亚王远亮黄美娜卓凤萍任凌燕陈芳陈楠
Owner 傅亚