scFv antibody, encoding gene thereof and application thereof to preparation of preparation for treating or preventing infectious bursal disease

A coding and genetic technology, applied in the direction of antiviral agents, applications, antibodies, etc., can solve the problems of poor controllability and restrictions in industrial production, and achieve the effects of avoiding horizontal transmission of diseases, strong specificity, and controllable quality of industrial production
CN103333242AActive Publication Date: 2013-10-02JIANGSU KANIONREAL BIOMEDICAL TECH CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
JIANGSU KANIONREAL BIOMEDICAL TECH CO LTD
Publication Date
2013-10-02

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Abstract

The invention discloses a scFv antibody, an encoding gene thereof and application thereof to preparation of preparations for treating or preventing an infectious bursal disease. The scFv antibody is formed by a heavy chain variable region, a light chain variable region and a connecting region between the heavy chain variable region and the light chain variable region. The heavy chain variable region is (a) or (b), wherein (a) refers to protein which is formed by amino acid residues at the first site to the 124th site of the sequence 1, and (b) refers to protein which is subject to substitution and / or depletion and / or addition of the amino acid residues of (a) and has the same activity; and the light chain variable region is (c) or (d), wherein (c) refers to protein which is formed by amino acid residues at the 140th site to the 244th site of the sequence 1, and (d) refers to protein which is subject to substitution and / or depletion and / or addition of the amino acid residues of (c) and has the same activity. The scFv antibody provided by the invention has the advantages of high specificity, good curative effect and the like and creates a new situation in the prevention and treatment history of IBDV (Infectious Bursal Disease Virus), and even in the prevention and treatment history of the entire animal virus diseases.
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Description

technical field

[0001] The invention relates to a scFv antibody, its coding gene and its application in preparing preparations for treating or preventing chicken infectious bursal disease. Background technique

[0002] Infectious Bursal Disease (IBD) is an acute and highly contagious chicken infectious disease caused by Infectious Bursal Disease Virus (IBDV). It is characterized by strong infectivity, high infection rate and high mortality rate. The disease has spread all over the world and is one of the most important diseases in the poultry industry, bringing huge economic losses to poultry enterprises.

[0003] IBDV can multiply rapidly in the lymphocytes, especially B lymphocytes, in the chick's bursa of Fabricius, prompting the apoptosis of the B lymphocytes, causing the extreme atrophy of the bursa of Fabricius, and finally leading to immunosuppression. Antibody drugs are currently effective therapeutic drugs. Hyperimmune serum and egg yolk antibodies can have good e...

Claims

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