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Xuan Gui particles and preparation method

A technology of granules and angelica, which is applied in the direction of pharmaceutical formulas, medical preparations containing active ingredients, block delivery, etc., can solve the problems of unsatisfactory analgesic effect and slow onset of effect, and achieve remarkable curative effect, fast onset of effect, and high transfer rate high effect

Inactive Publication Date: 2013-10-16
津药达仁堂集团股份有限公司第六中药厂
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the side effects of these Chinese patent medicines are small, they often take effect slowly, and mainly play the role of promoting blood circulation, removing blood stasis and regulating menstruation, but the analgesic effect is not ideal.

Method used

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  • Xuan Gui particles and preparation method
  • Xuan Gui particles and preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] A preparation method of Xuangui ointment, comprising the steps of:

[0021] (1) Weigh 40% Angelica sinensis, 40% Xuanhu, and 20% dried ginger by weight.

[0022] (2) Add 75% ethanol aqueous solution with a volume concentration equivalent to 5 times the mass of Angelica sinensis and dried ginger to the angelica and dried ginger, reflux for extraction for 2 hours, filter, recover ethanol from the filtrate and concentrate to a relative density at 80°C 1.20, let cool, extract with n-butanol, recover n-butanol from the extract and concentrate to obtain extract 1;

[0023] (3) Add the Herba Pediaceae to an aqueous ethanol solution with a volume concentration of 75% equivalent to 5 times the mass of Herba Pediaceae, reflux for extraction for 2 hours, filter, recover the ethanol from the filtrate and concentrate it to a concentrated solution with a relative density of 1.20 at 80°C , adjust the pH value to 7.5, extract with n-butanol, recover n-butanol from the extract and conc...

Embodiment 2

[0027] A preparation method of Xuangui ointment, comprising the steps of:

[0028] (1) Weigh 30% Angelica sinensis, 40% Xuanhu, and 30% dried ginger by weight.

[0029] (2) Add 99% ethanol aqueous solution with a volume concentration equivalent to twice the mass of angelica and dried ginger to the angelica and dried ginger, reflux for extraction for 1 hour, filter, recover ethanol from the filtrate and concentrate it to a relative density at 80°C 1.05, let it cool, extracted with ethyl acetate, recovered ethyl acetate from the extract and concentrated to obtain extract 1;

[0030] (3) Add the Herba Pediaceae to an aqueous ethanol solution with a volume concentration of 99% equivalent to 2 times the mass of Herba Pediaceae, reflux for extraction for 1 hour, filter, recover the ethanol from the filtrate and concentrate it to a concentrated solution with a relative density of 1.05 at 80°C , adjusting the pH value to 8, extracting with ethyl acetate, recovering ethyl acetate from...

Embodiment 3

[0034] A preparation method of Xuangui ointment, comprising the steps of:

[0035] (1) Weigh 50% Angelica sinensis, 30% Xuanhu, and 20% dried ginger by weight.

[0036] (2) Add 30% ethanol aqueous solution with a volume concentration equivalent to 8 times the mass of angelica and dried ginger to the angelica and dried ginger, reflux for extraction for 3 hours, filter, recover ethanol from the filtrate and concentrate it to a relative density at 80°C to 1.30, let it cool, extracted with butanone, recovered butanone from the extract and concentrated to obtain extract 1;

[0037] (3) Add the Herba Pediaceae to 30% ethanol aqueous solution with a volume concentration equivalent to 2-8 times the mass of Herba Pediaceae, reflux for extraction for 3 hours, filter, recover the ethanol from the filtrate and concentrate it to a relative density of 1.30 at 80°C The concentrated solution is adjusted to a pH value of 8.5, extracted with butanone, and the butanone is recovered from the ext...

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Abstract

The invention discloses Xuan Gui particles and a preparation method. The preparation method comprises the following steps: weighting Chinese angelica, corydalis tuber and dried ginger; adding ethanol water into Chinese angelica and dried ginger, performing reflux extraction, filtering, recycling ethyl alcohol, chilling, extracting with organic solvent, recycling organic solvent with extract liquor, and concentrating, so as to obtain extract 1; adding ethanol water into corydalis tuber, performing reflux extraction, filtering, recycling ethyl alcohol, adjusting Ph value, extracting with organic solvent, recycling organic solvent with extract liquor, and concentrating, so as to obtain extract 2; drying, smashing and mixing the extract 1 and the extract 2, so as to obtain a mixture; adding with saccharose, starch or dextrin into the mixture, and mixing uniformly, so as to prepare particles, and obtaining the particles after drying. The Xuan Gui particles have the effects of activating blood, dispersing blood stasis, warming menstruation and relieving pain, and is suitable for congealing cold blood stasis type and original type dysmenorrheal. The Xuan Gui particles prepared with the preparation method have the advantages of rapid onset, and significant effect, are convenient to take, and can treat both symptoms and root causes. Therefore, requirements of patients can be met, labor-hour of the preparation method is short, and the transfer rate of effective components is high.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine pharmacy, and relates to a traditional Chinese medicine preparation for treating dysmenorrhea and a preparation method thereof. Background technique [0002] Dysmenorrhea is a common disease in which women experience periodic lower abdominal pain as the main symptom during menstruation or before and after. Primary dysmenorrhea refers to those who have no obvious organic lesions in the reproductive organs on gynecological examination, and mostly occur in adolescent girls or young women who have not given birth 2-3 years after the beginning of menstruation. And the symptom of dysmenorrhea all exists in most girls or young women who do not give birth. In severe cases, abdominal pain, sore waist, pale face, dripping cold sweat, cold limbs, vomiting, diarrhea, or anal bulge can be seen, which seriously affects work, study and daily life, and brings pain to women. Dysmenorrhea has a higher ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9068A61K9/16A61P15/00
Inventor 周鸿佟永领刘丹王金磊高小芳
Owner 津药达仁堂集团股份有限公司第六中药厂