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Medicine for treating influenza and preparation method thereof

A technology for drugs and influenza, which is applied in the directions of drug combinations, pharmaceutical formulations, and medical preparations containing active ingredients, etc., to achieve the effects of low production cost, cheap and easy-to-obtain solvents, and remarkable drug effects.

Inactive Publication Date: 2013-10-30
INST OF CHINESE MATERIA MEDICA CHINA ACAD OF CHINESE MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The disease is self-limiting, but infants, the elderly, and patients with underlying cardiopulmonary diseases are prone to severe complications such as pneumonia and death

Method used

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  • Medicine for treating influenza and preparation method thereof
  • Medicine for treating influenza and preparation method thereof
  • Medicine for treating influenza and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0048] Embodiment 1, ethanol extraction process

[0049] Take gardenia medicinal material 1000g, impregnate with 9 times the amount of 30% (V / V) ethanol for 1.5 hours, reflux extraction twice, the first time for 2.5 hours, the second time for 6 times the amount of ethanol for 1.5 hours, filter, combine the filtrates, Recover ethanol under reduced pressure until there is no alcohol smell (-9Pa, 60°C) to obtain the alcohol extract; load the alcohol extract on ADS-17 macroporous resin, elute with 2 times the column volume of water, and discard the eluent; Continue to elute with 3 times column volume and 20% (V / V) ethanol, discard the eluent after reducing pressure to recover ethanol (-9Pa, 60°C); continue to use 4 times column volume and 50% concentration (V / V) ethanol was eluted, the eluent was decompressed to recover ethanol (-9Pa, 60°C), concentrated under reduced pressure (-9Pa, 70°C) to a relative density of 1.30 at 40°C, and the extract was obtained for future use. The obt...

Embodiment 2

[0050] Embodiment 2, tablet

[0051]Get the extract obtained in Example 1, add 25g of starch, mix well, dry at 80°C, pulverize, pass through a 40 mesh sieve, add 15g of microcrystalline cellulose, make soft material with 6% starch slurry, pass through a 14 mesh sieve for granulation, 60 Dry at ℃ until the moisture is lower than 5%, pass through a 14-mesh sieve and granulate to obtain an intermediate, add magnesium stearate according to 1% of the weight after granulation, mix well, and compress into tablets to obtain 1000 tablets. The intermediate prepared above contains 0.1% of the medicinal ingredient shanzhiside methyl ester.

Embodiment 3

[0052] Embodiment 3, water extraction process

[0053] Take 800g gardenia medicinal material, add 10 times the amount of water to soak for 1 hour, decoct twice, the first time is 2 hours, the second time is 8 times the amount of water, 1.5 hours, filter, combine the filtrates, and concentrate under reduced pressure to 1 gram of crude drug / ml (-9Pa, 80°C) to get the water extract, load the water extract on the ADS-17 macroporous resin, elute with 1.5 times the column volume, and discard the eluate; continue to use 2 times the column volume , the concentration is 10% (V / V) ethanol elution, and the eluent is discarded after reclaiming ethanol; Continue to elute with 5 times of column volume, concentration is 60% (V / V) ethanol, and the eluent is decompressed Recover ethanol (-9Pa, 60°C), concentrate under reduced pressure (-9Pa, 70°C) to a relative density of 1.25 at 45°C, and obtain an extract for future use, and add the obtained extract to pharmaceutically acceptable excipients...

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Abstract

The invention discloses a medicine composition for treating influenza and a preparation method of the medicine composition. The composition is prepared from jasmine medicinal materials by means of alcohol extraction or water extraction. The preparation method has the advantages that solvents are low in price and easily available, macroporous resins can be repeatedly used, the production cost is low and batch production is easily carried out. The medicine prepared by the invention is obvious in anti-influenza drug effect and has no obvious toxic and side effects.

Description

technical field [0001] The invention relates to a pharmaceutical composition, in particular to a pharmaceutical composition for treating influenza and a preparation method thereof. technical background [0002] Influenza is an acute respiratory infectious disease caused by influenza virus. It is highly contagious and has a high incidence rate, which can easily cause outbreaks or pandemics. It is mainly transmitted through droplets containing the virus, but can also be transmitted by person-to-person contact or contact with contaminated items. The typical clinical features are rapid onset of high fever, significant fatigue, and muscle aches all over the body, while upper respiratory catarrh symptoms such as nasal congestion, runny nose, and sneezing are relatively mild. High in autumn and winter. The disease is self-limiting, but it is prone to severe complications such as pneumonia and death in infants, young children, the elderly, and patients with underlying cardiopulmon...

Claims

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Application Information

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IPC IPC(8): A61K36/744A61P31/16A61P11/00A61P29/00
Inventor 崔晓兰黄成刚时宇静高英杰郭姗姗马荣时瀚田雪川
Owner INST OF CHINESE MATERIA MEDICA CHINA ACAD OF CHINESE MEDICAL SCI
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