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Application of Houttuynoid C in drug for treating atherosclerosis

A technology of atherosclerosis and drugs, applied in the application field of Houttuynoid C in the preparation of drugs for the treatment of atherosclerosis, can solve the problems that the etiology and pathogenesis have not been fully clarified, and there are no preventive measures and therapeutic drugs

Active Publication Date: 2015-04-29
煌途医药(无锡)有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Atherosclerosis (AS) is the main pathological basis of cardiovascular and cerebrovascular diseases. So far, its etiology and pathogenesis have not been fully elucidated, so there are no concise and effective preventive measures and therapeutic drugs.

Method used

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  • Application of Houttuynoid C in drug for treating atherosclerosis
  • Application of Houttuynoid C in drug for treating atherosclerosis
  • Application of Houttuynoid C in drug for treating atherosclerosis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0012] Embodiment 1: the preparation of compound Houttuynoid C tablet involved in the present invention:

[0013] Take 20 grams of compound Houttuynoid C, add 180 grams of conventional excipients for tablet preparation, mix well, and make 1000 tablets with a conventional tablet press.

Embodiment 2

[0014] Embodiment 2: the preparation of compound Houttuynoid C capsule of the present invention:

[0015] Get 20 grams of compound Houttuynoid C, add conventional auxiliary materials for preparing capsules such as 180 grams of starch, mix well, and pack into capsules to make 1000 tablets.

[0016] The following pharmacodynamic experiments will further illustrate its drug activity.

[0017] The present invention reveals the effect of Houttuynoid C on atherosclerosis through cell level research and establishment of atherosclerosis model.

[0018] Oral and intravenous injection of Houttuynoid C in the present invention can significantly reduce plaque area / intima area (%), intima thickness (um) / media thickness (%) in atherosclerotic rats; Triesters, total cholesterol and low-density lipoprotein levels decreased, indicating that Houttuynoid C can treat atherosclerosis.

[0019] Materials and Methods

[0020] 1. Experimental materials:

[0021] 1.1 Animals and feed

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PUM

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Abstract

The invention relates to an application of Houttuynoid C in preparation of a drug for treating atherosclerosis. Houttuynoid C plays a role in resisting atherosclerosis by regulating blood lipid and protecting endothelial cells. The anti-atherosclerosis drug prepared by Houttuynoid C has relatively good curative effect on atherosclerosis, and can be used for resisting atherosclerosis of human or animals. The application of Houttuynoid C in preparing anti-atherosclerosis drug is disclosed for the first time. Because a skeleton type of Houttuynoid C belongs to a brand new skeleton type, Houttuynoid C has an unexpectedly high inhibition activity on atherosclerosis, the possibility that other compounds give any enlightenment does not exist, and Houttuynoid C has prominent substantial characteristics and simultaneously obviously has significant progress in resisting atherosclerosis.

Description

technical field [0001] The invention relates to the application of Houttuynoid C in the preparation of drugs for treating atherosclerosis. Background technique [0002] Cardiovascular and cerebrovascular diseases are the most serious diseases that endanger human health and life in the contemporary era. They are common and frequently-occurring diseases among middle-aged and elderly people. Atherosclerosis (AS) is the main pathological basis of cardiovascular and cerebrovascular diseases. So far, its etiology and pathogenesis have not been fully elucidated, so there are no concise and effective prevention measures and therapeutic drugs. [0003] The compound Houttuynoid C involved in the present invention is published in 2012 (Chen, S. D. et al., 2012. Houttuynoid A-E, Anti-Herpes Simplex Virus Active Flavonoids with Novel Skeletons from Houttuynia cordata. Organic Letters 14 (7), 1772–1775. ), which has a new skeleton type, and its current use only involves active anti-herpe...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/7048A61P9/10
Inventor 丁圣雨
Owner 煌途医药(无锡)有限公司