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Application of Houttuynoid B in drug for treating atherosclerosis

An atherosclerosis and drug technology, which is applied in the application field of Houttuynoid B in the treatment of atherosclerosis drugs, can solve the problems such as the etiology and pathogenesis have not been fully elucidated, and there are no preventive measures and therapeutic drugs.

Active Publication Date: 2013-11-06
东台海滨科技创业园管理有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Atherosclerosis (AS) is the main pathological basis of cardiovascular and cerebrovascular diseases. So far, its etiology and pathogenesis have not been fully elucidated, so there are no concise and effective preventive measures and therapeutic drugs.

Method used

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  • Application of Houttuynoid B in drug for treating atherosclerosis
  • Application of Houttuynoid B in drug for treating atherosclerosis
  • Application of Houttuynoid B in drug for treating atherosclerosis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0012] Embodiment 1: the preparation of compound Houttuynoid B tablet involved in the present invention:

[0013] Take 20 grams of compound Houttuynoid B, add 180 grams of conventional excipients for tablet preparation, mix well, and make 1000 tablets with a conventional tablet press machine.

Embodiment 2

[0014] Embodiment 2: the preparation of compound Houttuynoid B capsules involved in the present invention:

[0015] Take 20 grams of compound Houttuynoid B, add conventional auxiliary materials for preparing capsules such as 180 grams of starch, mix well, and pack into capsules to make 1000 tablets.

[0016] The following pharmacodynamic experiments will further illustrate its drug activity.

[0017] The present invention reveals the effect of Houttuynoid B on atherosclerosis through cell level research and establishment of atherosclerosis model.

[0018] The present invention administers Houttuynoid B through oral and intravenous injection, which can significantly reduce plaque area / intima area (%), intima thickness (um) / media thickness (%) in atherosclerotic rats; Triesters, total cholesterol and low-density lipoprotein levels decreased, indicating that Houttuynoid B can treat atherosclerosis.

[0019] Materials and Methods

[0020] 1. Experimental materials:

[0021] 1...

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Abstract

The invention relates to an application of Houttuynoid B in preparing a drug for treating atherosclerosis. Houttuynoid B plays a role in resisting atherosclerosis by regulating blood lipid and protecting endothelial cells. The anti-atherosclerosis drug prepared by Houttuynoid B has relatively good curative effect on atherosclerosis, and can be used for resisting human or animal atherosclerosis. The application of Houttuynoid B in preparing the anti-atherosclerosis drug is disclosed for the first time. Because a skeleton type of Houttuynoid B belongs to a brand new skeleton type, Houttuynoid B has an unexpectedly high inhibition activity on atherosclerosis, and the possibility that other compounds give any enlightenment does not exist, Houttuynoid B has prominent substantial characteristics and simultaneously obviously has significant progress in resisting atherosclerosis.

Description

technical field [0001] The invention relates to the application of Houttuynoid B in the preparation of medicines for treating atherosclerosis. Background technique [0002] Cardiovascular and cerebrovascular diseases are the most serious diseases that endanger human health and life in the contemporary era. They are common and frequently-occurring diseases among middle-aged and elderly people. Atherosclerosis (AS) is the main pathological basis of cardiovascular and cerebrovascular diseases. So far, its etiology and pathogenesis have not been fully elucidated, so there are no concise and effective prevention measures and therapeutic drugs. [0003] The compound Houttuynoid B involved in the present invention was published in 2012 (Chen, S. D. et al., 2012. Houttuynoid A-E, Anti-Herpes Simplex Virus Active Flavonoids with Novel Skeletons from Houttuynia cordata. Organic Letters 14 (7), 1772–1775. ), which has a new skeleton type, and its current use only involves active anti-...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7048A61P9/10
Inventor 丁圣雨
Owner 东台海滨科技创业园管理有限公司