Titanium dioxide nanostructure lipid carrier and preparation method thereof
A nanostructured lipid and titanium dioxide technology, applied in cosmetic preparations, cosmetics, pharmaceutical formulations, etc., can solve the problems of low solubility and short action time, so as to improve solubility, increase action time, and avoid the possible impact of nano-toxicity Effect
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Embodiment 1 2
[0035] The preparation of embodiment 1 titanium dioxide nanostructure lipid carrier
[0036] Composition formula
[0037]
[0038]
[0039] Such as figure 1 Shown, the preparation steps of this embodiment are as follows:
[0040] 1. Weigh 2 grams of titanium dioxide, 0.05 grams of polyhydroxystearic acid, and 10 grams of glyceryl caprylate, and mix them uniformly to obtain a dispersion of titanium dioxide.
[0041] 2. Weigh 7 grams of steareth-20 and 6 grams of glyceryl monostearate, heat and mix at 75°C to obtain a uniform system at 75°C.
[0042] 3. Add the titanium dioxide dispersion into the homogeneous system prepared in (2), and heat and mix at 75°C.
[0043] 4. Weigh 74.95 grams of deionized water and heat to obtain a water phase at 75°C.
[0044] 5. Mix the oil phase in (3) with the water phase in (4) at 75°C and stir until completely emulsified.
[0045] 6. Homogenize the fully emulsified sample in (5) under high pressure at 75°C, the homogenization pressur...
Embodiment 2 2
[0047] The preparation of embodiment 2 titanium dioxide nanostructure lipid carrier
[0048] Composition formula
[0049]
[0050] Such as figure 1 Shown, the preparation steps of this embodiment are as follows:
[0051] 1. Weigh 4 grams of titanium dioxide, 0.05 grams of polyhydroxystearic acid, and 10 grams of glyceryl caprylate, and mix them uniformly to obtain a dispersion of titanium dioxide.
[0052] 2. Weigh 5 grams of steareth-20 and 6 grams of glyceryl monostearate, heat and mix at 75°C to obtain a uniform system at 75°C.
[0053] 3. Add the titanium dioxide dispersion into the homogeneous system prepared in (2), and heat and mix at 75°C.
[0054] 4. Weigh 72.95 grams of deionized water and heat to obtain a water phase at 75°C.
[0055] 5. Mix the oil phase in (3) with the water phase in (4) at 75°C and stir until completely emulsified.
[0056] 6. Homogenize the fully emulsified sample in (5) under high pressure at 75°C, the homogenization pressure is 60MPa, ...
Embodiment 3 2
[0058] Preparation of Example 3 Titanium Dioxide Nanostructured Lipid Carrier
[0059] Composition formula
[0060]
[0061] Such as figure 1 Shown, the preparation steps of this embodiment are as follows:
[0062] 1. Weigh 2 grams of titanium dioxide, 0.05 grams of polyhydroxystearic acid, and 10 grams of tritridecyl tribenzenetrilate, and mix them uniformly to obtain a titanium dioxide dispersion.
[0063] 2. Weigh 7 grams of steareth-20 and 6 grams of acetylated monoglyceride, heat and mix at 80°C to obtain a uniform system at 80°C.
[0064] 3. Add the titanium dioxide dispersion into the homogeneous system prepared in (2), and heat and mix at 80°C.
[0065] 4. Weigh 74.95 g of deionized water and heat to obtain an aqueous phase at 80°C.
[0066] 5. Mix the oil phase in (3) with the water phase in (4) at 80°C and stir until completely emulsified.
[0067] 6. Homogenize the fully emulsified sample in (5) under high pressure at 80°C, the homogenization pressure is 70M...
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