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Almotriptan tablet and preparation method thereof

A technology of almotriptan tablets and almotriptan, which is applied in the direction of pill delivery, pharmaceutical formulations, medical preparations of non-active ingredients, etc., can solve the problems of unfavorable drug efficacy and low dissolution rate of the main drug, and achieve dissolution good effect

Active Publication Date: 2014-01-22
YANGTZE RIVER PHARM GRP SICHUAN HAIRONG PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Almotriptan currently used is mostly administered in tablets, but due to the solubility of almotriptan itself, the dissolution rate of the main drug in some tablets is low, which is not conducive to the efficacy of the drug

Method used

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  • Almotriptan tablet and preparation method thereof
  • Almotriptan tablet and preparation method thereof
  • Almotriptan tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] The preparation of embodiment 1 tablet of the present invention

[0026] Prescription:

[0027]

[0028] Preparation:

[0029] Pass the raw materials through a 100-mesh sieve and the auxiliary materials through a 80-mesh sieve. Mix the raw materials, mannitol, microcrystalline cellulose, and 50% sodium carboxymethyl starch successively, add 10% povidone K30 aqueous solution to make a soft material, granulate with a 20-mesh sieve, and dry at 60°C , 20-mesh sieve for granulation, add the remaining sodium carboxymethyl starch and magnesium stearate from the excipients, mix evenly, and compress into tablets.

Embodiment 2

[0030] The preparation of embodiment 2 tablet of the present invention

[0031] Prescription:

[0032]

[0033] Preparation:

[0034] Pass the raw materials through a 100-mesh sieve and the auxiliary materials through a 80-mesh sieve. Mix the raw materials and the internally added auxiliary materials sodium carboxymethyl starch, mannitol, and microcrystalline cellulose in sequence, add 10% povidone K30 aqueous solution to make a soft material, granulate with a 20-mesh sieve, and dry at 60°C. Sieve through a 20-mesh sieve, add magnesium stearate as an excipient, mix evenly, and compress into tablets.

Embodiment 3

[0035] The investigation of embodiment 3 tablet auxiliary material of the present invention

[0036] 1. Quality screening of molded tablets

[0037] Tablets are prepared according to the prescription shown in Table 1, and the quality of the tablets is detected, thereby screening out the best conditions of the present invention, and the detection results are shown in Table 2.

[0038] Prescription 1~9 preparation process:

[0039] Pass the raw materials through a 100-mesh sieve and the auxiliary materials through a 80-mesh sieve. Mix the raw materials and the internally added auxiliary materials sodium carboxymethyl starch, mannitol, and microcrystalline cellulose in sequence, add 10% povidone K30 aqueous solution to make a soft material, granulate with a 20-mesh sieve, and dry at 60°C. Sieve through a 20-mesh sieve, add magnesium stearate as an excipient, mix evenly, and compress into tablets.

[0040] Prescription 10 preparation process:

[0041] Pass the raw materials th...

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PUM

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Abstract

The invention provides an almotriptan tablet, which is prepared from the following raw materials and accessories by weight: 15-20 parts of malic acid almotriptan, 20-50 parts of mannitol, 20-50 parts of microcrystalline cellulose, 2-8 parts of sodium carboxymethyl starch and a proper amount of a lubricant. Through screening on the proportion of raw materials and accessories, the invention finally prepares the almotriptan tablet with good appearance shape and dissolution rate, and provides a new choice for clinical medication.

Description

technical field [0001] The invention relates to an almotriptan tablet and a preparation method thereof. Background technique [0002] Migraine is a chronic neurovascular disorder, characterized by diffuse or unilateral attacks, severe pain, and recurrent attacks. Triptans are a new generation of drugs for the treatment of migraine. They selectively stimulate 5-HT receptors with strong specificity and clear curative effect. [0003] Almotriptan is a new generation of 5-HT receptor agonist, highly selective for intracranial vascular 5-HT1B / D1 receptors, can selectively regulate the contraction of intracranial blood vessels, and may interact with the trigeminal neurovascular system Interaction, inhibition of plasma protein extravasation in dural vessels following stimulation of the trigeminal ganglion. The currently used almotriptan is mostly administered in tablets, but due to the solubility of almotriptan itself, the dissolution rate of the main drug in some tablets is low,...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K31/4045A61K47/38A61K47/36A61K47/10A61P25/06
Inventor 吴品江周唯兰马英花周芯宇李元波
Owner YANGTZE RIVER PHARM GRP SICHUAN HAIRONG PHARM CO LTD