A kind of nanoscale cellulose hollow hard capsule and preparation method thereof

Abstract

The invention discloses a nanometer level cellulose hollow hard capsule and a preparation method thereof. The main raw material of the capsule wall forming material of the nanometer level cellulose hollow hard capsule is nanometer level cellulose, the capsule is refined by adding auxiliary materials into the nanometer level cellulose, the capsule is cylindered, the capsule is a hollow capsule which is sleeved by a cap and a body, hard in quality and elastic, and the depth of the capsule wall is from 0.08mm to 0.16mm. The reparation method of the nanometer level cellulose hollow hard capsule comprises the steps of preparing nanometer level cellulose water phase colloid, gel mixed liquor of the nanometer level cellulose water phase colloid, and plasticizer and dispersant-containing uniform mixed liquor, so as to obtain the nanometer level cellulose glue solution for preparing the hollow hard capsule, blanking by means of glue dipping, drying, pulling a housing, demoulding, cutting, tidying in a registration way, and sterilizing, so as to prepare the nanometer level cellulose hollow hard capsule finished product. The nanometer level cellulose hollow hard capsule prepared by the method is non-toxic, rapid in disintegration speed, clean in appearance, long in storage time, and high in safety. The method is easy and simple to carry out, convenient to operate, and capable of preparing the hollow hard capsule which is low in cost and good in stability.

Description

technical field [0001] The invention relates to a hollow hard capsule and a preparation method thereof, in particular to a nanoscale cellulose hollow hard capsule and a preparation method thereof, belonging to the technical field of pharmaceutical preparations. Background technique [0002] The encapsulation container that can completely wrap the drug capsule core is called hollow hard capsule. The hollow hard capsule is in the shape of a cylinder and is divided into upper and lower matching sections, namely the capsule body and the capsule cap, both of which have their own grooves and wedges. The hollow hard capsule is refined from the raw material of the wall material of the capsule and added auxiliary materials. Among them, there are various kinds of wall material raw materials for cyst formation, and commonly used wall material raw materials for cyst formation can be classified into natural, semi-synthetic or synthetic polymer materials. [0003] 1. Natural polymer ma...

AI Technical Summary

Problems solved by technology

Therefore, the validity period of capsule preparation medicines has to be shortened to meet the requirements of gelatin capsule packaging materials, which objectively causes a huge waste of preparations; and protein substances are prone to cross-linking and curing reactions when they meet aldehyde substances, which limit animal The scope of use of gelatin hollow hard capsules: In addition, the disintegration performance of gelatin hollow hard capsules in the body is easy to fluctuate, which often makes it difficult to accurately release the active ingredients of the drug

The viscosity of gelatin solution is greatly affected by temperature. During the production process, it is easy to cause difficulties in the control of the hollow hard capsule preparation process (such as changes in wall thickness, changes in drying and molding conditions, etc.) The performance of the finished product (such as mechanical strength, disintegration characteristics, etc.)