Unlock instant, AI-driven research and patent intelligence for your innovation.

Bifonazole vaginal expansion suppository and its preparation method and detection method

The technology of vaginal expansion suppository and bifonazole, which is applied in the directions of suppository delivery, pharmaceutical formulation, and material inspection products, can solve the problems of suppository easy deformation, easy rancidity, and increase stability, so as to avoid secondary infection and bioavailability. High degree and stable effect

Active Publication Date: 2016-02-24
哈尔滨田美药业股份有限公司
View PDF1 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Bifonazole suppositories are used to treat vulvovaginal candidiasis; for example, Wang Huizhen et al. 16(6): 278) discloses a suppository made of 1g of bifonazole and 99g of mixed fatty acid glycerides; the suppository is easily deformed and rancid, so its properties are unstable; Zhang Xiurong et al. (Zhang Xiurong, Wang Dan, Yang Hui et al. Preparation and quality standard research of bifonazole central control effervescent suppository [J], Chinese Pharmacy, 2010, 21(17): 1587-1589) disclosed a kind of bifonazole, semi-synthetic fatty acid glycerol A hollow effervescent suppository made of ester, citric acid and sodium bicarbonate. The matrix and active ingredients in the suppository are separated to increase the stability; and the suppository has a wide range of effects, but due to the water-solubility of bifonazole In addition, common bifonazole suppositories are not easy to clean and easily contaminate clothes; the active ingredient has a small contact surface with the human body, resulting in insufficient absorption and no exertion. Technical issues such as the best curative effect of the prescription

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Bifonazole vaginal expansion suppository and its preparation method and detection method
  • Bifonazole vaginal expansion suppository and its preparation method and detection method
  • Bifonazole vaginal expansion suppository and its preparation method and detection method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0089]

[0090] Preparation:

[0091] 1) Preparation of drug-containing matrix:

[0092] a. heating and melting the mixed fatty acid glyceride and polyethylene glycol 4000 in a water bath to obtain a melt;

[0093] b. adding bifonazole to the melt obtained in step a and mixing uniformly to obtain a drug-containing matrix;

[0094]2) Preparation of expansive suppository: Pour the drug-containing matrix into a suppository mold, insert a tampon, cool and shape, and make 100 conical suppositories, each weighing about 3.4g.

Embodiment 2

[0096]

[0097] Preparation:

[0098] 1) Preparation of drug-containing matrix:

[0099] a. placing semi-synthetic fatty acid glycerides and polyoxyethylene monostearate in a water bath for heating and melting to obtain a melt;

[0100] b. uniformly mixing bifonazole with polyethylene glycol 32 glycerol monolaurate to prepare the first mixture;

[0101] c. adding the first mixture to the melt obtained in step a, and mixing evenly to obtain a drug-containing matrix;

[0102] 2) Preparation of expansive suppository: Pour the drug-containing matrix into a suppository mold, insert a tampon, cool and shape, and make 100 egg-shaped suppositories, each weighing about 3.0 g.

Embodiment 3

[0104]

[0105] Preparation method: 100 duckbill-shaped suppositories were prepared according to the method in Example 2, each weighing about 2.9g.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
water absorptionaaaaaaaaaa
Login to View More

Abstract

The invention relates to a bifonazole vaginal expansion suppository and a preparation method and a detection method thereof. The expansion suppository comprises a drug-containing matrix formed by bifonazole and a matrix and an expansion carrier; polyethylene glycol 32 glycerin is added to the drug-containing matrix Monolaurate, chitin, potassium sorbate, xylitol anhydride monostearate and monodecanoyl glycerol, the bifonazole vaginal expansive suppository has high stability, uniform drug dispersion, and no irritation Small size, high bioavailability, significant curative effect and other beneficial effects; and the provided bifonazole vaginal expansion suppository adopts six original leading technologies, which can prevent the outflow of medicinal liquid and prevent secondary infection.

Description

technical field [0001] The invention belongs to the field of vaginal suppositories, in particular to a bifonazole vaginal expansion suppository and a preparation method and detection method thereof. Background technique [0002] Bifonazole, the chemical name is (±)-1-(α-biphenyl-4-ylbenzyl)-1H-imidazole, and its structural formula is as follows: [0003] [0004] Bifonazole is a white-like lipid yellowish crystalline powder; odorless, bitter; easily soluble in chloroform, slightly soluble in methanol or absolute ethanol, almost insoluble in water. [0005] Bifonazole is an imidazole antifungal drug, and its antibacterial matrix is ​​a dual inhibitor of fungal cell membrane ergosterol synthesis. In addition to acting on P450-14a demethylation like other imidazole drugs, it also acts on hydroxymethylglutamate Coenzyme A reductase has a broad-spectrum antifungal effect, and can inhibit 90% of pathogenic fungi; existing creams, gels, suppositories, etc. 2010 version of China...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/02A61K31/4174A61K47/34A61K47/36A61K47/26A61K47/10G01N33/15G01N5/04G01N21/78A61P31/10
Inventor 邱学良邱明世
Owner 哈尔滨田美药业股份有限公司