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Polyethylene glycol-polysarcosine double hydrophilic block copolymer and its synthesis method

A block copolymer, polyethylene glycol technology, applied in the synthesis field of polyethylene glycol-polysarcosine double hydrophilic block copolymer

Active Publication Date: 2016-03-02
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are no reports on the dual hydrophilic block copolymers containing polysarcosine blocks.

Method used

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  • Polyethylene glycol-polysarcosine double hydrophilic block copolymer and its synthesis method
  • Polyethylene glycol-polysarcosine double hydrophilic block copolymer and its synthesis method
  • Polyethylene glycol-polysarcosine double hydrophilic block copolymer and its synthesis method

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] Add 0.395g (3.4mmol) of Sar-NCA to the reaction flask, dissolve it with 1.5mL N,N-dimethylformamide, then add 0.31mL mPEG200-NH 2 DMF solution (0.022mol / L, 0.0068mmol), Sar-NCA and mPEG200-NH 2 The molar ratio is 500:1, sealed and placed in a 40°C oil bath to react for 24 hours. After the reaction, the mixture is poured into diethyl ether to precipitate, filtered, and the obtained polymer is vacuum-dried to obtain a polypeptide with a yield of 95 %. The NMR number average molecular weight of the obtained polymer was 33.9 KDa, and the molecular weight distribution was 1.2.

Embodiment 2

[0044] Other polymerization conditions are identical with embodiment 1, difference is to use mPEG5000-NH 2 As the initiator to initiate the ring-opening polymerization of Sar-NCA, the solvent is N,N-dimethylacetamide, Sar-NCA and mPEG5000-NH 2 The molar ratio was 5:1, and the reaction was carried out in a constant temperature bath at 0°C for 4 days, and the yield of the obtained peptide was 90%. The NMR number average molecular weight of the obtained polymer was 5.4KDa, and the molecular weight distribution was 1.1.

Embodiment 3

[0046] Other polymerization conditions are identical with embodiment 1, difference is to use NH 2 -PEG10000-NH 2 As the initiator to initiate the ring-opening polymerization of Sar-NCA, the solvent is N-methylpyrrolidone, Sar-NCA and NH 2 -PEG10000-NH 2 The molar ratio was 100:1, and the reaction was carried out in a constant temperature bath at 80°C for 12 hours, and the yield of the obtained polypeptide was 100%. The NMR number-average molecular weight of the obtained polymer was 17.1 KDa, and the molecular weight distribution was 1.2.

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Abstract

The invention discloses a method for synthesizing a novel polyethylene glycol-b-polysarcosine double hydrophilic block copolymer. The method comprises the steps of with methoxy polyoxamide or polyethylene glycol diamine as an initiator, initiating ring opening polymerization of sarcosine-N-carboxylic anhydride or sarcosine-N-thio-carboxylic anhydride, reacting for 12 hours to 4 days at a reaction temperature of 0-100 DEG C, so as to prepare the polyethylene glycol-b-polysarcosine block copolymer. The method has the beneficial effects that the utilized initiator is low in cost and high in reaction yield (more than 95%) and initiating activity, is easy to prepare and can be used for carrying out polymerization reaction in multiple solvents; the block proportion of a prepared product is controllable, the molecular weight of a polyethylene glycol block can be regulated in a range of 200-10000, the molecular weight of a poly-sarcosine glycol block can be regulated in the range of 350-35000, and the molecular weight distribution of the product is narrow and is lower than 1.2.

Description

technical field [0001] The invention belongs to the field of polymer synthesis, and in particular relates to a synthesis method of polyethylene glycol-polysarcosine double hydrophilic block copolymer. Background technique [0002] Polypeptide is a class of excellent biomimetic materials with excellent biocompatibility and biodegradability. Compared with traditional polymer materials, such as polylactone, polylactide, polycarbonate, polyanhydride, polyphosphazene, etc., peptide materials have great advantages. Polypeptide materials are made from natural amino acids, and their raw materials are rich in sources, not limited to petroleum resources, and can be degraded in the body to obtain the amino acids necessary for the human body, and will not cause inflammatory reactions in the body. It is the most biocompatible material. [0003] At this stage, more and more reports have begun to focus on the application of polypeptide materials in the field of biomedicine. Polypeptide ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08G69/40C08G69/42
Inventor 凌君陶鑫峰
Owner ZHEJIANG UNIV