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Valine continuous crystallization method

A technology of valine, valine feed liquid, applied in chemical instruments and methods, preparation of organic compounds, organic chemistry and other directions, can solve problems such as high energy consumption, no literature discloses amino acid crystallization, low efficiency, etc., achieves steam High utilization rate, avoid valine agglomeration, reduce the effect of valine agglomeration

Active Publication Date: 2015-04-22
MENGZHOU CITY HUAXING BIOCHEM ENG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This method consumes a lot of energy and is inefficient
[0004] Many methods of crystallizing materials using multi-effect evaporators are disclosed in the prior art, such as Chinese patent 200710130643.8, Chinese patent 201110029274.X, and Chinese patent 200820082957.5. The multi-effect evaporator crystallization methods recorded in these documents are all used for non-caking Materials, for materials like amino acids, especially valine, which are easy to agglomerate, these multi-effect evaporators are no longer suitable
In the prior art, there is no document disclosing the use of a multi-effect evaporator to crystallize amino acids

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] 1) Adjust the pH of the purified valine feed solution to 8~9, with a content of 4~5%;

[0020] 2) Entering the five-effect evaporator, the fifth effect starts to feed and control the vacuum-0.086MPa, the temperature is 40℃~45℃; it enters the fourth-effect vacuum-0.08MPa~MPa, the temperature is 50℃~55℃; the three-effect vacuum-0.075 MPa, temperature 63°C~67°C; second effect vacuum -0.04MPa~-0.05MPa, temperature 68°C~72°C; first effect vacuum -0.02MPa~-0.03MPa, temperature 85°C~90°C;

[0021] 3) The second-effect feed pipeline is a forced circulation pipeline, the flow rate of the second-effect circulation is 300m3 / h, and the first-effect circulation is 450m3 / h, so as to prevent the material from agglomerating on the tube wall of the falling film evaporator;

[0022] 4) The second-effect pipeline and the first-effect pipeline are equipped with external ultrasonic equipment. When the production is running, the ultrasonic equipment is turned on to prevent the material from ...

Embodiment 2

[0027] 1) Adjust the pH of the purified valine feed solution to 8~9, with a content of 4~5%;

[0028] 2) Entering the five-effect evaporator, the fifth effect starts to feed and control the vacuum -0.09MPa, the temperature is 40°C~45°C; sequentially enters the fourth effect vacuum -0.084MPa, the temperature is 50°C~55°C; the third effect vacuum -0.075MPa, Temperature 63°C~67°C; second effect vacuum -0.04MPa~-0.05MPa, temperature 68°C~72°C; first effect vacuum -0.02MPa~-0.03MPa, temperature 85°C~90°C;

[0029] 3) The second-effect feed pipeline is a forced circulation pipeline, the flow rate of the second-effect circulation is 300m3 / h, and the first-effect circulation is 450m3 / h, so as to prevent the material from agglomerating on the tube wall of the falling film evaporator;

[0030] 4) The second-effect pipeline and the first-effect pipeline are equipped with external ultrasonic equipment. When the production is running, the ultrasonic equipment is turned on to prevent the ma...

Embodiment 3

[0035] 1) Adjust the pH of the purified valine feed solution to 8~9, with a content of 4%;

[0036] 2) Enter the five-effect evaporator, the fifth effect starts to feed the material to control the vacuum -0.086MPa~-0.09MPa, the temperature is 40℃~45℃; enter the four-effect vacuum in turn -0.08MPaMPa, the temperature is 50℃~55℃; the three-effect vacuum -0.075MPa, temperature 63℃~67℃; second effect vacuum -0.04MPa~-0.05MPa, temperature 68℃~72℃; first effect vacuum -0.02MPa~-0.03MPa, temperature 85℃~90℃;

[0037] 3) The second-effect feed pipeline is a forced circulation pipeline, the flow rate of the second-effect circulation is 300m3 / h, and the first-effect circulation is 450m3 / h, so as to prevent the material from agglomerating on the tube wall of the falling film evaporator;

[0038] 4) The second-effect pipeline and the first-effect pipeline are equipped with external ultrasonic equipment. When the production is running, the ultrasonic equipment is turned on to prevent the m...

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PUM

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Abstract

The invention discloses a valine continuous crystallization method. The purified valine feed liquid flows through a quintuple effect evaporator first and then the evaporated feed liquid is subjected to the single pot crystallization and separation to obtain valine crystal. According to the method, the valine feed liquid is concentrated and crystallized by the adopted quintuple effect evaporator; the vapor utilization ratio is high; as the valine is easy to lump on pipelines in the evaporator, the valine yield is low; as a first-effect feeding pipeline and a second-effect feeding pipeline are forced circulation pipeline, and the forced circulation flux is preferably selected and the valine discharging concentration is selected; therefore, the valine lumps can be effectively reduced; however, the lump cannot be completely avoided; an external ultrasonic device is mounted on the first-effect feeding pipeline and the second-effect feeding pipeline in a matching manner; therefore, the valine lumps can be completely avoided.

Description

technical field [0001] The invention relates to a continuous crystallization method of valine. Background technique [0002] Valine is one of the 20 kinds of amino acids that make up protein. Its chemical name is 2-amino-3-methylbutyric acid. Concentrations of amino acids (isoleucine and leucine) work together to promote normal body growth, repair tissue, regulate blood sugar, and provide needed energy. When participating in strenuous physical activity, valine can provide muscles with extra energy to produce glucose to prevent muscle weakness. It also helps remove excess nitrogen (a potential toxin) from the liver and transports the nitrogen it needs throughout the body. [0003] At present, the production of valine mainly includes chemical synthesis and microbial fermentation. The valine mother liquor obtained by the microbial fermentation method is subjected to membrane separation and extraction technology to obtain valine feed liquid, and then single-pot crystallizatio...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07C229/08C07C227/40C07C227/42
Inventor 赵俊杨晓明马秋红
Owner MENGZHOU CITY HUAXING BIOCHEM ENG