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Method for improving polypeptide membrane hydrophilicity by adopting polypropylene glycol and polyvinyl alcohol

A polypropylene glycol and polyvinyl alcohol technology, which is applied in the field of polymer film preparation, can solve the problems of lack of hydrophilicity in the polypeptide film, and achieve the effects of improving the hydrophilicity of the polypeptide modified film, being easy to master and simple to operate.

Inactive Publication Date: 2014-05-28
SHANDONG UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Polypeptide is a biomaterial with good biocompatibility and biodegradability. Polypeptide film can be used as artificial skin, etc., but the lack of good hydrophilicity of polypeptide film limits its application to some extent. application

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] 1) Synthesis of polypeptide-polypropylene glycol graft copolymer:

[0015] Add 12 grams of poly(r-benzyl-L-glutamate) with a molecular weight of 60,000, 3.1 grams of polypropylene glycol monobutyl ether with a molecular weight of 1000, 0.9 grams of p-toluenesulfonic acid, and 260 ml of Dimethyl sulfoxide solvent, under an inert atmosphere, stirred and reacted at 55°C for 3 days, terminated the reaction, and then obtained the target product by filtration, dialysis, and drying;

[0016] 2) Preparation of Polypropylene Glycol and Polyvinyl Alcohol Modified Polypeptide Film:

[0017] Add 10 grams of polypeptide-polypropylene glycol graft copolymer and 38 milliliters of dimethyl sulfoxide solvent into the dry reactor, and add polyvinyl alcohol (molecular weight: 4000) accounting for 1% of the total weight of the modified membrane, under an inert atmosphere , after stirring and mixing at 40°C for 50 minutes, film was formed by casting method, and dried in a vacuum oven at 50...

Embodiment 2

[0020] 1) Synthesis of polypeptide-polypropylene glycol graft copolymer:

[0021] Add 12 grams of molecular weight to 70000 poly(r-ethyl-L-glutamate), 5.3 grams of polypropylene glycol monobutyl ether and 0.91 grams of p-toluenesulfonic acid with a molecular weight of 1500, and then add 230 milliliters of di Methyl sulfoxide solvent, under an inert atmosphere, stirred and reacted at 56°C for 4 days, terminated the reaction, and then obtained the target product by filtration, dialysis, and drying;

[0022] 2) Preparation of Polypropylene Glycol and Polyvinyl Alcohol Modified Polypeptide Film:

[0023] Add 10 grams of polypeptide-polypropylene glycol graft copolymer and 36 milliliters of dimethyl sulfoxide solvent into the drying reactor, and add polyvinyl alcohol (molecular weight: 4500) accounting for 2% of the total weight of the modified membrane, under an inert atmosphere , after stirring and mixing at 45°C for 60 minutes, the cast method was used to form a film, and dried...

Embodiment 3

[0026] 1) Synthesis of polypeptide-polypropylene glycol graft copolymer:

[0027] Add 12 grams of poly(r-methyl-L-glutamate) with a molecular weight of 80,000, 7.2 grams of polypropylene glycol monobutyl ether with a molecular weight of 2000, 1.03 grams of p-toluenesulfonic acid, and 177 milliliters of di Methyl sulfoxide, under an inert atmosphere, stirred and reacted at 58°C for 3 days, terminated the reaction, and then obtained the target product by filtration, dialysis, and drying;

[0028] 2) Preparation of Polypropylene Glycol and Polyvinyl Alcohol Modified Polypeptide Film:

[0029] Add 10 grams of polypeptide-polypropylene glycol graft copolymer and 35.5 milliliters of dimethyl sulfoxide into the drying reactor, and add polyvinyl alcohol (molecular weight: 5000) accounting for 3% of the total weight of the modified membrane. Under an inert atmosphere, After stirring and mixing at 50° C. for 70 minutes, a film was formed by casting method, and dried in a vacuum oven at...

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PUM

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Abstract

The invention discloses a method for improving polypeptide membrane hydrophilicity by adopting polypropylene glycol and polyvinyl alcohol. The method comprises the following steps: (1) synthesis of the polypeptide-polypropylene glycol graft copolymer: adding polypeptide homopolymer, polypropylene glycol monobutyl ether, a solvent and a catalyst into a dry reactor, under the inert atmosphere, and stirring and reacting for 3-4 days at the temperature of 55-58 DEG C, so that the target product is obtained through filtering, dialyzing and drying; (2) preparation for the polypeptide membrane modified by the polypropylene glycol and the polyvinyl alcohol: adding the polypeptide-polypropylene glycol graft copolymer, polyvinyl alcohol and a solvent into the dry reactor, under the inert atmosphere, stirring and mixing for 50-70 min at the temperature of 45-50 DEG C, forming the membrane through tape casting, and drying, so that the target product is obtained. The method has the advantages that the preparation technology is simple and easy to master, and the hydrophilicity of the modified membrane is improved greatly.

Description

technical field [0001] The invention relates to a method for improving the hydrophilicity of a polypeptide film, belonging to the technical field of polymer film preparation. Background technique [0002] Polypeptide is a biomaterial with good biocompatibility and biodegradability. Polypeptide film can be used as artificial skin, etc., but the lack of good hydrophilicity of polypeptide film limits its application to some extent. application. Polypropylene glycol has good biocompatibility and biodegradability, and has good blendability with polyvinyl alcohol. Polyvinyl alcohol has good biocompatibility and biodegradability, and has excellent hydrophilicity. First, the polypropylene glycol segment is introduced into the polypeptide segment to form a polypeptide-polypropylene glycol graft copolymer to improve the blendability of the polypeptide, and then the polyvinyl alcohol segment is added to the polypeptide-polypropylene glycol graft copolymer to form a copolymer. The m...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08L87/00C08L29/04C08G81/00C08J5/18
Inventor 朱国全王发刚柳玉英
Owner SHANDONG UNIV OF TECH