Carvedilol orally disintegrating tablet

A technology of carvedilol and disintegrating tablets, which is applied in the directions of medical preparations of inactive ingredients, pill delivery, cardiovascular system diseases, etc., can solve the problems of difficult medication, inconvenience for patients, etc. Rapid disintegration effect

Inactive Publication Date: 2014-06-11
倪伟华
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Ordinary tablets and capsules are very inconvenient for patients who have difficulty swallowing. Although dispersible tablets can solve th

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0024] Example 1

[0025] The ratio of the main drug and auxiliary ingredients of carvedilol orally disintegrating tablets:

[0026] Carvedilol 10g

[0027] Microcrystalline cellulose 40g

[0028] Erythritol 40g

[0029] Low-substituted hydroxypropyl cellulose 5g

[0030] Aspartame 5g

[0031] Sweet orange flavor 7g

[0032] Magnesium stearate 1.5g

[0033] Polyacrylic resin Ⅳ appropriate amount

[0034] Specific steps are as follows:

[0035] 1) Crush the auxiliary materials and pass through an 80-mesh sieve for use;

[0036] 2) Prepare 100 mL of 5% polyacrylic acid IV resin (70%) alcohol solution as a binder;

[0037] 3) According to the prescription, mix the microcrystalline cellulose, erythritol, low-substituted hydroxypropyl cellulose, aspartame and orange flavor, add 90mL of binder to make soft material, and granulate with 18 mesh sieve. Drying at 60℃~70℃, the dried granules are passed through a 20-mesh sieve and granulated;

[0038] 4) Weigh magnesium stearate according to the pr...

Example Embodiment

[0043] Example 2

[0044] The ratio of the main drug and auxiliary ingredients of carvedilol orally disintegrating tablets:

[0045] Carvedilol 10g

[0046] Microcrystalline cellulose 30g

[0047] Erythritol 30g

[0048] Low-substituted hydroxypropyl cellulose 10g

[0049] Aspartame 5g

[0050] Sweet orange flavor 5g

[0051] Magnesium stearate 1.0g

[0052] Polyacrylic resin Ⅳ appropriate amount

[0053] Specific steps are as follows:

[0054] 1) Crush the auxiliary materials and pass through an 80-mesh sieve for use;

[0055] 2) Prepare 100 mL of 5% polyacrylic acid IV resin (70%) alcohol solution as a binder;

[0056] 3) According to the prescription, mix microcrystalline cellulose, erythritol, low-substituted hydroxypropyl cellulose, aspartame and orange flavor, add 80mL of binder to make soft material, and granulate with 18 mesh sieve. Drying at 60℃~70℃, the dried granules are passed through a 20-mesh sieve and granulated;

[0057] 4) Weigh magnesium stearate according to the presc...

Example Embodiment

[0062] Example 3

[0063] The ratio of the main drug and auxiliary ingredients of carvedilol orally disintegrating tablets:

[0064] Carvedilol 10g

[0065] Microcrystalline cellulose 35g

[0066] Erythritol 25g

[0067] Low-substituted hydroxypropyl cellulose 15g

[0068] Aspartame 5g

[0069] Sweet orange flavor 5g

[0070] Magnesium stearate 1.0g

[0071] Polyacrylic resin Ⅳ appropriate amount

[0072] Specific steps are as follows:

[0073] 1) Crush the auxiliary materials and pass through an 80-mesh sieve for use;

[0074] 2) Prepare 100 mL of 5% polyacrylic acid IV resin (70%) alcohol solution as a binder;

[0075] 3) According to the prescription, mix microcrystalline cellulose, erythritol, low-substituted hydroxypropyl cellulose, aspartame and orange flavor, add 80mL of binder to make soft material, and granulate with 18 mesh sieve. Drying at 60℃~70℃, the dried granules are passed through a 20-mesh sieve and granulated;

[0076] 4) Weigh magnesium stearate according to the presc...

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Abstract

The invention discloses a carvedilol orally disintegrating tablet, comprising the following components by weight percentage: 5-20% of carvedilol as a main component, 20-60% of microcrystalline cellulose and 10-40% of erythritol as fillers, 3-15% of aspartame and 2-10% of sweet orange essence as sweeteners, 0.5-3% of magnesium stearate as a lubricant, and a proper amount of polyacrylic acid IV resin alcohol solution as an adhesive. Adopting the technical scheme of the invention, the carvedilol orally disintegrating tablet has the beneficial effect that the tablet is convenient for administration by patients with hypertension in the condition of lack of drinking water, can disintegrate and release quickly in the oral cavity, and has good taste. A preferable technical scheme is that the polyacrylic acid IV resin alcohol solution has an ethanol concentration of 50-70%.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, in particular to carvedilol orally disintegrating tablets. Background technique [0002] Carvedilol, the chemical name is 1-carbazole-4-oxyl-3-[2-(2-methoxyphenoxy)ethylamino]-2-propanol. The molecular formula is: , Carvedilol is clinically used to treat mild to moderate hypertension, either alone or in combination with other antihypertensive drugs (especially thiazide diuretics). Treat symptomatic congestive heart failure. Carvedilol is a newly listed variety in recent years. It is a new type of α, β-receptor blocker and an anti-adrenergic drug with dual effects in treating hypertension and chronic heart failure. The drug was successfully developed by Roche and first launched in 1991 under the trade name "Daliquan". The patent in the United States expired on March 5, 2002. On April 30, 1999, the China Food and Drug Administration approved the production of Carvedilol from the Inst...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K31/403A61K47/38A61P9/12
Inventor 倪伟华
Owner 倪伟华
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