A kind of penicillin V potassium tablet and preparation method thereof

The technology of penicillin V and equal increment method is applied in directions such as pharmaceutical formulations, medical preparations of non-active ingredients, and pill delivery, which can solve the problems of complexity, high production cost, long process flow, etc. Simple and stable effect

Active Publication Date: 2017-01-04
NORTHEAST PHARMA GRP SHENYANG SHIDE PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the prescription of penicillin V potassium ordinary tablets is relatively complicated, and the method of wet granulation is mainly used for production. Under the conditions of high humidity, high temperature and oxidation, penicillin products ar

Method used

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  • A kind of penicillin V potassium tablet and preparation method thereof
  • A kind of penicillin V potassium tablet and preparation method thereof
  • A kind of penicillin V potassium tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0030] Example one

[0031] Table 3 Prescriptions for different addition amounts of sodium alginate

[0032]

[0033] It is prepared by powder direct compression method, the specific method is as follows:

[0034] (1) Weigh penicillin V potassium and excipients according to the prescription;

[0035] (2) Mix penicillin V potassium, compressible starch, and talc powder in the mixer according to the equal increment method to obtain the first mixed powder;

[0036] (3) Mix the sodium alginate and micro-powdered silica gel uniformly in the mixer according to the equal increasing method to obtain the second mixed powder;

[0037] (4) After the first mixed powder and the second mixed powder are uniformly mixed in the mixer according to the equal increment method, the materials are discharged and compressed with a circular die to obtain penicillin V potassium tablets.

Example Embodiment

[0038] Example two

[0039] Table 4 Prescriptions with different ratios

[0040]

[0041] It is prepared by powder direct compression method, the specific method is as follows:

[0042] (1) Weigh penicillin V potassium and excipients according to the prescription;

[0043] (2) Mix penicillin V potassium, compressible starch, and talc powder in the mixer according to the equal increment method to obtain the first mixed powder;

[0044] (3) Mix the sodium alginate and micro-powdered silica gel uniformly in the mixer according to the equal increasing method to obtain the second mixed powder;

[0045] (4) After the first mixed powder and the second mixed powder are uniformly mixed in the mixer according to the equal increment method, the materials are discharged and compressed with a circular die to obtain penicillin V potassium tablets.

Example Embodiment

[0046] Example three

[0047] For prescription 3, the following methods were used to prepare penicillin V potassium tablets.

[0048] Method 1: Use powder direct compression method to prepare, the specific method is as follows:

[0049] (1) Weigh penicillin V potassium and excipients according to the prescription;

[0050] (2) Mix penicillin V potassium, compressible starch, and talc powder in the mixer according to the equal increment method to obtain the first mixed powder;

[0051] (3) Mix the sodium alginate and micro-powdered silica gel uniformly in the mixer according to the equal increasing method to obtain the second mixed powder;

[0052] (4) After the first mixed powder and the second mixed powder are uniformly mixed in the mixer according to the equal increment method, the materials are discharged and compressed with a circular die to obtain penicillin V potassium tablets.

[0053] Method 2: Use the powder direct compression method to prepare, the specific method is as follows:...

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PUM

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Abstract

A penicillin V potassium tablet applied in the field of penicillin V potassium tablet preparations and a preparation method thereof, consisting of penicillin V and auxiliary materials, wherein the auxiliary materials are compressible starch, sodium alginate, micronized silica gel, and talcum powder. Penicillin V Potassium Tablets are composed of the following components by weight percentage: Penicillin V Potassium 30%‑40%, compressible starch 55%‑65%, sodium alginate 0.6%‑1%, micronized silica gel 1.5%‑2%, Talc powder 2%-3%; the described penicillin V potassium tablet is composed of the following components in weight percentage: penicillin V potassium 38.2%, compressible starch 56.9%, sodium alginate 0.6%-1%, micronized silica gel 1.8% , talcum powder 2.3%; described penicillin V potassium tablet is made up of the following components by weight percentage: penicillin V potassium 38.2%, compressible starch 56.9%, sodium alginate 0.8%, micronized silica gel 1.8%, talcum powder 2.3% ; The method is powder direct compression method. The invention has the advantages of simple prescription, fast disintegration, good stability, good fluidity of the prescription mixed powder, no sticking and punching during tablet compression, no capping phenomenon of the tablet, simple preparation method, and better stability of the prepared tablet.

Description

technical field [0001] The invention relates to a penicillin V potassium tablet in the field of penicillin V potassium preparations and a preparation method thereof. Background technique [0002] Penicillin V (penicillin V) is the phenoxymethyl derivative of penicillin G, penicillin V potassium (penicillin Vpotassium) is the potassium salt of penicillin V, its molecular formula is C 16 h 17 KN 2 o 5 S, with a molecular weight of 388.5, is the first natural antibiotic for oral administration in the world and the second naturally occurring β-lactam antibiotic with clinical value after penicillin G. It has been widely used since it was launched in 1953. application. [0003] This product is not destroyed after oral administration, acid-resistant and stable, absorbed in the duodenum quickly and completely, the absorption rate is 60%, and its absorption is not affected by the food in the stomach. Its antibacterial spectrum and antibacterial activity are the same as those of ...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K31/43A61K47/36A61K47/04A61P31/04
Inventor 李家杰何睦一王慧颖孙瑞峰周联波
Owner NORTHEAST PHARMA GRP SHENYANG SHIDE PHARMA
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