Liquid blood platelet storage method and liquid blood platelet storage device

A storage device and storage method technology, applied in the field of medicine, can solve the problems of reducing the activation of stored platelets and the expression level of CD62p, and achieve the effects of reducing storage damage, improving in vitro function, and reducing loss.

Inactive Publication Date: 2014-09-24
SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are also no reports about hydrogen reducing the activation and CD62p expression levels of stored platelets, and hydrogen being used for platelet storage at 22±2°C in liquid state

Method used

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  • Liquid blood platelet storage method and liquid blood platelet storage device
  • Liquid blood platelet storage method and liquid blood platelet storage device
  • Liquid blood platelet storage method and liquid blood platelet storage device

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Slowly inject pure hydrogen gas into the airtight blood bag containing concentrated or apheresis platelets through a 0.22 μm filter (Millipore, USA) (the gas is added to the platelet liquid surface to avoid air bubbles, 10 liters / min, and continue to inflate for 2 minutes), hydrogen gas Dissolve into platelet liquid to form saturated hydrogen water. During storage, put the platelet storage bag into a closed space (platelet storage box), keep the hydrogen gas volume concentration at 3.5% in the closed space, and maintain the hydrogen gas concentration in the platelet liquid above 25 μM / L. Concentrated or apheresis platelets added with hydrogen can be stored in a platelet storage box at 22±2°C for 5 days.

Embodiment 2

[0039] The storage method is the same as in Example 1, except that the hydrogen volume concentration is kept at 2% in the closed space.

Embodiment 3

[0041] The storage method is the same as in Example 1, except that the hydrogen volume concentration is kept at 10% in the closed space.

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PUM

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Abstract

The invention belongs to the technical field of medicines, and in particular relates to a liquid blood platelet storage method and a liquid blood platelet storage device. During storage of a closed space with concentrated or single donor platelets, the temperature is kept to be 22+ / -2 DEG C, and the volume concentration of hydrogen is 3.5 percent; the storage device is a closed constant-temperature device capable of being introduced with hydrogen. According to the storage method and the storage device, the loss of the concentrated or single donor platelets at the temperature of 22+ / -2 DEG C in the storage period can be reduced; due to hydrogen, the activation and CD62p expression level of the platelets can be reduced; the storage injury of the platelets is alleviated, and the in-vitro function of the platelets is enhanced.

Description

technical field [0001] The invention relates to the technical field of medicine, and relates to a method and special equipment for using hydrogen to store platelets in a liquid state at 22±2°C. Background technique [0002] Platelets are important hemostatic and coagulation components in blood, and platelet transfusion is an irreplaceable clinical treatment for bleeding caused by thrombocytopenia or platelet dysfunction. (22±2)°C continuous shaking storage is currently a recognized method of platelet storage at home and abroad, but with the prolongation of storage time, platelets will undergo a series of changes in shape, function and metabolism——platelet storage lesion . [0003] Although a large number of new technologies have been applied to platelet storage, such as highly permeable platelet storage bags, platelet storage additives, low temperature and cryopreservation of platelets, etc., so far no optimal storage method to reduce platelet storage damage has been found....

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A01N1/02
Inventor 顾海慧钱宝华查占山臧燕郭慧军
Owner SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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