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Cancer treating system and method

A technology for tumors and cancerous tissues, applied in the field of medical engineering, can solve problems such as unsatisfactory effects, no treatment methods, and large side effects

Inactive Publication Date: 2014-10-08
SHANGHAI JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Current tumor treatments such as surgery, radiotherapy and chemotherapy are not effective and have serious side effects
Especially for tumors that have metastasized, there are few effective treatments

Method used

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  • Cancer treating system and method
  • Cancer treating system and method
  • Cancer treating system and method

Examples

Experimental program
Comparison scheme
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Embodiment

[0090] 1. Materials and Methods

[0091] 1.1 Animals, cell lines and main reagents

[0092] 6-8 weeks-old SPF Balb / c female mice (Shanghai Slack Animal Center) were raised in cages with independent ventilation boxes, and the light was changed artificially for 12 hours day and night. free access to mice 60 Co radiation sterilized feed and high temperature sterilized water. Mouse 4T1 breast cancer cells (obtained from Shanghai First People's Hospital, in other embodiments, other breast cancer cells such as T47D cell lines can be used), were cultured in 10% newborn fetal bovine serum (Hangzhou Siji Clear Co., Ltd.) and double antibodies (100U / mL penicillin, 100g / mL streptomycin) (Shanghai Sangon Bioengineering Technology Service Co., Ltd.) in RPMI1640 medium (Hyclone, USA). Ultrafine precipitated barium sulfate particles were purchased from Shanghai Zewen Trading Co., Ltd. Antibodies FITC-labeled CD4 and PE-labeled CD8 for flow cytometry and immunofluorescence were purchased ...

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Abstract

The invention provides a system and method for regulating CD4+T cell levels in cancer patients and particularly provides a device for improving the CD4+T cell levels of mammals having cancer tissues. The device comprises a cooling treatment unit and a heating treatment unit, wherein the cooling treatment unit is used for cooling the cancer tissues, and the heating treatment unit is used for heating the cancer tissues. The invention further provides a method for improving the CD4+T cell levels in the cancer patients, wherein the method comprises the steps of performing cooling treatment on the cancer tissues and performing heating treatment on the cancer tissues.

Description

technical field [0001] The invention belongs to the field of medical engineering, in particular, the invention relates to a method for regulating CD4 in tumor patients + Systems and methods at the T cell level. Background technique [0002] Tumor is one of the main causes affecting human health. Theoretically speaking, the immune system can recognize the tumor as the non-self of the body, thereby inhibiting the occurrence and development of the tumor, but in fact, the tumor host usually has low immunity and cannot produce effective anti-tumor immunity. In recent years, the tumor immunoediting hypothesis about the interaction between tumor development and the body's immune system has attracted people's attention. The hypothesis holds that tumor cells form a stable tumor immune tolerance pattern by reducing their own immunogenicity, down-regulating the expression of co-stimulatory molecules on the cell surface, releasing a large number of immunosuppressive factors, and recru...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61B18/02A61B18/12
CPCA61B18/02A61B18/04A61F7/007A61F2007/0063A61N1/403A61N5/025A61N5/0625A61N2005/0659A61N5/067A61F7/00A61F7/12
Inventor 徐学敏张爱丽刘苹白景峰孙建奇
Owner SHANGHAI JIAOTONG UNIV
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