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Application of indinavir sulfate in the preparation of drugs for preventing or treating endotoxemia and sepsis

A technology of indinavir sulfate and endotoxemia, applied in the field of application of indinavir sulfate in the preparation of drugs for the prevention or treatment of endotoxemia and sepsis, can solve the pharmacological problems of indinavir sulfate The effect has not been reported and other issues

Inactive Publication Date: 2016-10-19
BINZHOU MEDICAL COLLEGE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Used alone to treat adult patients who are not clinically suitable for treatment with nucleoside or non-nucleoside reverse transcriptase inhibitors, but the pharmacological effects of indinavir sulfate in the prevention or treatment of endotoxemia and sepsis have not been reported

Method used

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  • Application of indinavir sulfate in the preparation of drugs for preventing or treating endotoxemia and sepsis
  • Application of indinavir sulfate in the preparation of drugs for preventing or treating endotoxemia and sepsis
  • Application of indinavir sulfate in the preparation of drugs for preventing or treating endotoxemia and sepsis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0011] Example 1 Preparation of Indinavir Sulfate Freeze-Dried Powder for Injection

[0012] Take 50.0g of indinavir sulfate, add 2000ml of water for injection to dissolve it, add 8g of mannitol, stir to dissolve, and ultra-filter to obtain a clear liquid without pyrogen, pour it into a 10ml vial, 2ml / bottle, press the freeze-dried powder Freeze-dried by needle process to make freeze-dried powder injections each containing 50.0 mg of indinavir sulfate.

Embodiment 2

[0013] Example 2 Preparation of Indinavir Sulfate Capsules

[0014] Weigh 200.0g of indinavir sulfate and 100.0g of sodium carboxymethyl starch, mix well and pass through a 100 mesh sieve, add an appropriate amount of 3% PVP K30 Appropriate amount of water solution to prepare soft material, granulate with 20-mesh sieve, dry at 60°C for 3 hours, sieve with 18-mesh sieve for granulation, add 2.0g of magnesium stearate, mix well and pack into capsules, adjust the weight of the capsules to about 200mg.

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Abstract

The invention provides a new drug application of indinavir sulfate, in particular to indinavir sulfate inhibiting the expression of high mobility group protein B1 (high mobility group protein, HMGB1) thereby inhibiting endotoxemia and sepsis Developed to prevent or treat endotoxemia and sepsis. In the above application, the dosage range for injection is 50mg-2000mg; preferably 50-1000mg; the dosage range for oral administration is 100mg-6000mg; preferably 200-3000mg.

Description

technical field [0001] The present invention relates to indinavir sulfate inhibiting the occurrence and development of sepsis so as to prevent or treat endotoxemia and sepsis; specifically to indinavir sulfate inhibiting high mobility group protein B1 (high mobility group protein, HMGB1 ), so as to prevent or treat endotoxemia and sepsis. Background technique [0002] Sepsis (sepsis), that is, sepsis. It is a clinical syndrome caused by infection. Suppurative pathogenic bacteria invade the bloodstream and reproduce in large quantities, and spread to the whole body with the bloodstream, causing new multiple suppurative lesions in tissues and organs. Sepsis is often accompanied by the following signs: higher or lower body temperature, increased or decreased white blood cells, tachycardia, shortness of breath or abnormal increase in minute ventilation, if two or more of these symptoms appear clinically, Sepsis can be diagnosed; when it is accompanied by organ failure, it is ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/496A61P31/00A61P7/00
Inventor 蒋王林许勇吕长俊亢泽春
Owner BINZHOU MEDICAL COLLEGE