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A kind of amphiphilic photoswitchable fluorescent polymer nanoparticle and preparation method thereof

A fluorescent polymer and nanoparticle technology, applied in chemical instruments and methods, luminescent materials, etc., can solve problems such as complex preparation process, poor repeatability, surfactant migration or aggregation instability, and improve photostability , enhance the fluorescence brightness, improve the stability of the effect

Inactive Publication Date: 2016-03-30
HUNAN UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, among these existing preparation methods, the sol-gel method has harsh synthesis conditions and poor reproducibility; the nanoparticle surface modification method and the block copolymer self-assembly method require complex preparation processes, which are not conducive to large-scale Preparation and commercial production; while the conventional micro / miniemulsion method requires the use of common ionic or nonionic surfactants, instability due to migration or aggregation of surfactants will occur in complex physiological environments

Method used

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  • A kind of amphiphilic photoswitchable fluorescent polymer nanoparticle and preparation method thereof
  • A kind of amphiphilic photoswitchable fluorescent polymer nanoparticle and preparation method thereof
  • A kind of amphiphilic photoswitchable fluorescent polymer nanoparticle and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0028] Example 1: Preparation of amphiphilic photoswitchable fluorescent polymer nanoparticles by one-step RAFT miniemulsion polymerization.

[0029] (1) Add 0.5g methyl methacrylate, 0.003g 2,6-diethyl-8-(4-(methacryloyloxy)phenyl-1,3,5,7-tetramethyl-fluoro Borodimethylene (BDPMA), 0.015g ethyl-3,3-dimethyl-6-nitroindoline spiropyranyl methacrylate (SPMA), 0.025g n-hexadecane, 0.006g azobis Mix and stir isobutyronitrile evenly, then disperse in 10ml aqueous solution of polyethylene oxide macromolecular chain transfer agent with a concentration of 0.0075g / mL, ultrasonically emulsify to form a stable and uniform fine emulsion, and react at 75°C for 7 hours to obtain this Amphiphilic photoswitchable fluorescent polymer nanoparticles.

Embodiment 2

[0030] Example 2: Test the particle size and distribution of the amphiphilic photoswitchable fluorescent polymer nanoparticle sample prepared in Example 1.

[0031] The specific test instrument is MalvernNano-ZS90 laser particle size analyzer, the test concentration is 0.3wt% solid content, and the test temperature is 25oC.

[0032] figure 2 It is the particle size and distribution diagram of the amphiphilic photoswitchable fluorescent polymer nanoparticle sample prepared in Example 1, and the result shows that the average particle size of the prepared fluorescent polymer nanoparticle sample is 80nm, and the particle size distribution is narrow.

Embodiment 3

[0033] Embodiment 3: Test the ultraviolet-visible absorption spectrum and fluorescence emission spectrum of the amphiphilic photoswitchable fluorescent polymer nanoparticle sample prepared in embodiment 1.

[0034] The specific test instruments are: ShimadzuUV-2501PC ultraviolet-visible absorption spectrometer, ShimadzuRF-5301PC fluorescence spectrometer, the test concentration is 0.3wt% solid content, and the test temperature is 25oC.

[0035] (1) UV-Vis absorption spectrum

[0036] image 3 It is the ultraviolet-visible absorption spectrum of the amphiphilic photoswitchable fluorescent polymer nanoparticle sample prepared in Example 1 in the range of 300nm to 700nm. From image 3It can be seen from the figure that under the irradiation of 525nm visible light (power 2W, the same below), the sample has an absorption peak corresponding to BDPMA at 525nm, and almost no absorption peak corresponding to SPMA at 560nm; , the same below), the sample showed absorption peaks corres...

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Abstract

The invention discloses amphipathy photoswitch fluorescent polymer nano particles and a preparing method of the amphipathy photoswitch fluorescent polymer nano particles. Methyl methacrylate, polymerizable green fluorescence dye and a polymerizable photochromic compound are taken as monomers, hexadecane is taken as hydrophobe, a polyoxyethylene macromolecular chain transfer reagent is taken as a surface active agent, a one-step reversible addition-fragmentation chain transfer (RAFT) miniemulsion polymerization method is adopted for preparing the novel amphipathy photoswitch fluorescent polymer nano particles. The amphipathy photoswitch fluorescent polymer nano particles can emit intense macroscopic green or red fluorescence under irradiation of visible light and ultraviolet light, and have fast photoresponse capacity and good repeated fluorescence reversible switch performance. The amphipathy photoswitch fluorescent polymer nano particles have wide application prospects in the fields of cell imaging, bioanalysis, optical storage and the like.

Description

technical field [0001] The invention relates to the field of material preparation, in particular to amphiphilic light-switchable fluorescent polymer nanoparticles with fluorescence reversible switch performance under the irradiation of ultraviolet light and visible light and a preparation method thereof. Background technique [0002] In recent years, optically switchable fluorescent materials have received increasing attention in the fields of ultra-high-resolution cell imaging, labeling of complex biological systems, and ultra-high-density optical data storage applications. For example, optical switching fluorescent materials based on spiropyran derivatives, diarylethene derivatives, etc. have good optical rewritable repeatability and low production cost, which provides a low-cost optical ultra-high density storage technology. new possibilities. On the other hand, compared with conventional fluorescent probes, probe materials with optical switch fluorescence characteristic...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08F220/14C08F220/34C08F220/36C08F2/38C08F2/30C09K11/06
Inventor 陈建钟维邦李亚吕锟李明莉廖博易平贵
Owner HUNAN UNIV OF SCI & TECH