A kind of preparation method of Maxing Shigan oral liquid

The technology of Shigan oral liquid and maxing is applied in the field of preparation of veterinary traditional Chinese medicine oral liquid, which can solve the problems of low extraction rate of active ingredients of medicinal materials, large loss of active ingredients, reduced economic benefits, etc., and achieves increased utilization of medicinal materials and particle size of medicinal materials Small, high equipment requirements

Active Publication Date: 2016-08-17
HENAN SOAR VETERINARY PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Maxing Shigan oral liquid prescription comes from Zhang Zhongjing's Treatise on Febrile Diseases in the Eastern Han Dynasty. The prescription is reasonable and effective. It is suitable for a variety of respiratory diseases caused by exogenous wind-heat and evil attacking the lung surface. At present, there are medicinal active ingredients in the traditional extraction process Disadvantages such as low extraction rate and low bioavailability
Most of the active ingredients of Chinese herbal medicines are wrapped in the cell wall. Due to the obstruction of the main component of the cell wall, the traditional extraction methods often have low extraction efficiency and large loss of active ingredients, resulting in waste of resources and greatly reducing the economic benefits of preparation.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] A preparation method of Maxing Shigan oral liquid, characterized in that it comprises the following steps: (1) take 300g of ephedra, 300g of bitter almond, 1500g of gypsum, and 300g of licorice, and pulverize the four kinds of medicinal materials into a medicinal material mixture, and pass through 20 mesh sieve spare;

[0022] (2) Heat purified water 6 times the weight of the medicinal material mixture to 80°C, add the medicinal material mixture sieved in step (1), and soak for 10 minutes;

[0023] (3) When the medicinal liquid obtained in step (2) is cooled to 45°C, adjust the pH to 4.5 with 40% (mass) citric acid aqueous solution, add 0.5g of compound enzyme, stir evenly, enzymatically hydrolyze for 1 hour, and then heat up to 75°C Enzyme inactivation treatment is carried out; the composite enzyme is composed of the following mass fractions of enzymes: 25% cellulase, 40% hemicellulase, and the balance is pectinase;

[0024] (4) Decoct the medicinal liquid obtained in...

Embodiment 2

[0029] A preparation method of Maxing Shigan oral liquid, comprising the following steps: (1) taking 500 g of ephedra, 500 g of bitter almond, 2000 g of gypsum and 400 g of licorice, pulverizing the four kinds of medicinal materials together into a medicinal material mixture, passing through a 20-mesh sieve for subsequent use;

[0030] (2) Heat purified water 10 times the weight of the medicinal material mixture to 85°C, add the medicinal material mixture sieved in step (1), and soak for 30 minutes;

[0031] (3) When the medicinal liquid obtained in step (2) is cooled to 50° C., adjust the pH to 5.0 with 30% (mass) citric acid aqueous solution, add 0.4 g of compound enzyme, stir evenly, enzymatically hydrolyze for 0.8 h, and then heat up to 80 ℃ for enzyme inactivation treatment; the composite enzyme is composed of enzymes with the following mass fractions: 30% cellulase, 35% hemicellulase, and the balance is pectinase;

[0032] (4) Decoct the medicinal liquid obtained in step...

Embodiment 3

[0037] A preparation method of Maxing Shigan oral liquid, comprising the following steps: (1) taking 400g of ephedra, 400g of bitter almond, 1800g of gypsum, and 500g of licorice, pulverizing the four kinds of medicinal materials together into a medicinal material mixture, passing through a 20-mesh sieve for subsequent use;

[0038] (2) Heat purified water 8 times the weight of the medicinal material mixture to 82°C, add the medicinal material mixture sieved in step (1), and soak for 20 minutes;

[0039] (3) When the medicinal solution obtained in step (2) is cooled to 48°C, adjust the pH to 4.8 with 35% (mass) citric acid aqueous solution, add 0.6g of compound enzyme, stir well, enzymatically hydrolyze for 0.9h, and then heat up to 78°C ℃ for enzyme inactivation treatment; the composite enzyme is composed of enzymes with the following mass fractions: 20% cellulase, 30% hemicellulase, and the balance is pectinase;

[0040] (4) Decoct the medicinal liquid obtained in step (3) f...

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PUM

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Abstract

The invention belongs to a preparation method of jute-semen armeniacae amarae-gypsum-liquorice oral solution. All the medicinal materials are smashed and sieved before being extracted, the particle size of the medicinal materials is small, a plant cell wall can be broken more easily, the action area between an enzyme and a substrate is larger, and the dissolution rate of active ingredients of the medicinal materials is higher; according to flavour characteristic of the jute-semen armeniacae amarae-gypsum-liquorice oral solution, a compound enzyme is added for assisting extraction, the compound enzyme can be used for rapidly and effectively breaking structures such as plant cell wall cellulose and impurities such as pectin at optimal temperature and pH, the dissolution rate of the active ingredients of the medicinal materials is increased, operation is simple and easy, and the requirement on equipment is low; enzyme extraction can be carried out at low temperature, so that the extraction time is shortened, and the loss ratio of thermosensitive ingredients in a medical solution is reduced, so that the availability of the medicinal materials is improved, resources are saved, and the production cost is reduced.

Description

technical field [0001] The invention belongs to the technical field of preparation of veterinary traditional Chinese medicine oral liquid, and in particular relates to a preparation method of Maxing Shigan oral liquid. Background technique [0002] Maxing Shigan oral liquid is a traditional Chinese medicine oral liquid for chickens included in the second volume of "Veterinary Drug Local Standards Up to National Standards". The main ingredients are ephedra, almonds, gypsum, and licorice. This product clears away heat, clears the lung, relieves asthma, mainly treats cough and asthma due to lung heat, and is clinically used for the prevention and treatment of various respiratory diseases in chickens. [0003] At present, the second volume of "Veterinary Drug Local Standards Upgrading National Standards" and the Ministry of Agriculture's announcement No. 1760, the preparation method of Maxing Shigan Oral Liquid is as follows: decoct the 4 medicinal materials with water twice, co...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/736A61K9/08A61P11/00
Inventor 付文力王彬李灵娟李攀登
Owner HENAN SOAR VETERINARY PHARMA
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