Biodegradable material and method for producing biodegradable material

A biodegradable, compound technology, used in drug delivery, pharmaceutical formulations, bandages, etc., can solve problems such as polymer particle deformation, and achieve the effects of improved biodegradability, improved shear strength, and improved recovery rate

Inactive Publication Date: 2014-12-10
TORAY IND INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0029] However, improved techniques such as blending of various polymers (Patent Document 7) and use of chemically crosslinked polymer particles (Patent Document 8) and surface coating of polymer particles (Patent Document 9) are not available. In other words, improvements have been confirmed in terms of controllin

Method used

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  • Biodegradable material and method for producing biodegradable material

Examples

Experimental program
Comparison scheme
Effect test

Example

[0222] (Example 1)

[0223] The branched polymer a1 is 10.0g of 8-branched PEG (SUNBRIGHT (registered trademark) HGEO5000; manufactured by NOF Corporation) and the hydroxycarboxylic acid a2 is 22.0g of lactide (PURASORB L; manufactured by PURAC BIOMATERIALS). To the eggplant type bottle. These were melted and mixed at 120°C in an argon atmosphere, and 0.94 mL of tin(II) octoate toluene solution was added as a catalyst (tin(II) octoate (manufactured by Sigma-Aldrich Co.) was dissolved in toluene (Wako Pure Chemical Industries, Ltd.) In Kogyo Co., Ltd.), the concentration was adjusted to 0.16 g / mL), and the copolymerization reaction was performed under normal pressure for 20 hours to obtain an unrefined multi-component compound A1.

[0224] The obtained unrefined polyvalent compound A1 was added dropwise to 100 mL of diethyl ether, and the precipitate and the liquid components separated from the diethyl ether were collected, and they were further washed with 50 mL of diethyl ether t...

Example

[0234] (Example 2)

[0235] Change the amount of solution 1 to 0.199mL, the amount of solution 2 to 0.450mL, the amount of solution 3 to 0.351mL, the amount of DMAP solution to 0.023mL, and the amount of EDC to 0.040mL. Except for this, the same operation as in Example 1 was performed to obtain a biodegradable film 2 and an acetonitrile-containing film 2.

[0236] With respect to these biodegradable film 2 and acetonitrile-containing film 2, the same evaluations as in Example 1 were performed, and the results are shown in Table 1.

[0237] As shown in Table 1, the biodegradable film 2 has a large residual weight ratio, a large compression load, and a high recovery rate. In addition, the composite elastic modulus of the acetonitrile-containing film 2 is large.

Example

[0238] (Example 3)

[0239] Except for changing the polyvalent compound A1 to 8-branched PEG (SUNBRIGHT (registered trademark) HGEO5000; manufactured by NOF Corporation), the same operation as in Example 1 was performed to obtain a solution 4. The weight average molecular weight of 8-branched PEG (SUNBRIGHT (registered trademark) HGEO5000; manufactured by NOF Corporation) measured by the GPC method is 5000.

[0240] Change the amount of 0.295mL solution 1 to 0.120mL solution 4, change the amount of solution 2 to 0.555mL, change the amount of solution 3 to 0.325mL, change the amount of DMAP solution to 0.028mL, and change the amount of EDC to Except 0.049 mL, the same operation as in Example 1 was performed to obtain a biodegradable film 3 and an acetonitrile-containing film 3.

[0241] About these biodegradable film 3 and acetonitrile-containing film 3, the same evaluation as Example 1 was performed, and the result is shown in Table 1.

[0242] As shown in Table 1, the biodegradable ...

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Abstract

The objective of the present invention is to provide a biodegradable material having improved flexibility, an increased percentage of shape recovery after the material has been deformed, and improved biodegradability. The present invention provides a biodegradable material resulting from chemically crosslinking: a polyvalent compound (A) having at least three functional groups (X) such as hydroxyl groups; a polyvalent compound (B) having at least three functional groups such as carboxyl groups; and a compound (C) having a structure derived from a hydroxycarboxylic acid and having a glass transition point of the homopolymerized homopolymer thereof of no greater than -40°C.

Description

technical field [0001] The present invention relates to a biodegradable material and a method for producing the biodegradable material. Background technique [0002] Poly(lactic acid / glycolic acid) copolymers are used as polymer particles for embolization of blood vessels in order to stop bleeding during incision of the affected part, block the nutrient supply to the tumor, maintain the concentration of anticancer agents in the tumor, etc. (Patent Document 1); block copolymers of polyethylene glycol and polylactic acid (Patent Documents 2 to 5); or multi-block copolymers obtained by copolymerizing lactic acid, polyethylene glycol, and polycarboxylic acids (Patent Document 6 ). [0003] Such polymer particles used to embolize blood vessels and the like have a problem in that they cannot be rapidly biodegraded after finishing their role. In addition, spherical particles are used to reliably embolize blood vessels without gaps, but since they are delivered to target sites suc...

Claims

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Application Information

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IPC IPC(8): A61L31/00A61L15/16C08G63/06C08L101/16
CPCA61L24/0042A61L31/148C08L101/16A61L15/64A61L2400/04C08L67/025C08L67/04A61L15/26A61L24/046
Inventor 藤田雅规中西惠棚桥一裕
Owner TORAY IND INC
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