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Biodegradable material and method for producing biodegradable material

A biodegradable, compound technology, used in drug delivery, pharmaceutical formulations, bandages, etc., can solve problems such as polymer particle deformation, and achieve the effects of improved biodegradability, improved shear strength, and improved recovery rate

Inactive Publication Date: 2014-12-10
TORAY IND INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0029] However, improved techniques such as blending of various polymers (Patent Document 7) and use of chemically crosslinked polymer particles (Patent Document 8) and surface coating of polymer particles (Patent Document 9) are not available. In other words, improvements have been confirmed in terms of controlling the flexibility of polymer particles and improving catheter penetrability, but sufficient improvement has not been confirmed for the problem that polymer particles deform and do not return to their original shape. In order to obtain a suitable The embolization effect of blood vessels etc. needs further improvement

Method used

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  • Biodegradable material and method for producing biodegradable material

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1）

[0223] 10.0 g of branched chain polymer a1, 8-branched PEG (SUNBRIGHT (registered trademark) HGEO5000; manufactured by NOF Corporation) and hydroxycarboxylic acid a2, namely 22.0 g of lactide (PURASORB L; manufactured by PURAC BIOMATERIALS) were extracted. into an eggplant-shaped bottle. These were melt-mixed at 120° C. under an argon atmosphere, and 0.94 mL of tin (II) octoate toluene solution was added as a catalyst (tin (II) octoate (manufactured by Sigma-Aldrich Co.,) was dissolved in toluene (Wako Pure Chemical Industries, Ltd. Co., Ltd. (manufactured by Co., Ltd., adjusted to a concentration of 0.16 g / mL), a copolymerization reaction was performed under normal pressure for 20 hours to obtain an unpurified multi-component compound A1.

[0224] The obtained unrefined multi-component compound A1 was added dropwise to 100 mL of diethyl ether, and after the precipitate and liquid components separated from diethyl ether were collected, they were further washed with 50 mL of di...

Embodiment 2）

[0235] Change the amount of solution 1 to 0.199mL, change the amount of solution 2 to 0.450mL, change the amount of solution 3 to 0.351mL, change the amount of DMAP solution to 0.023mL, and change the amount of EDC to 0.040mL, Except for this, the same operation as in Example 1 was carried out to obtain the biodegradable membrane 2 and the acetonitrile-containing membrane 2 .

[0236] These biodegradable film 2 and acetonitrile-containing film 2 were evaluated in the same manner as in Example 1, and the results are shown in Table 1.

[0237] As shown in Table 1, the biodegradable film 2 had a large residual weight ratio, a large compressive load, and a high recovery rate. In addition, the composite elastic modulus of the acetonitrile-containing film 2 is large.

Embodiment 3）

[0239] Solution 4 was obtained in the same manner as in Example 1, except that multi-component compound A1 was changed to 8-branched PEG (SUNBRIGHT (registered trademark) HGEO5000; manufactured by NOF Corporation). The weight-average molecular weight of 8-branched PEG (SUNBRIGHT (registered trademark) HGEO5000; manufactured by NOF Corporation) measured by the GPC method was 5,000.

[0240] Change the amount of solution 1 from 0.295mL to 0.120mL of solution 4, change the amount of solution 2 to 0.555mL, change the amount of solution 3 to 0.325mL, change the amount of DMAP solution to 0.028mL, change the amount of EDC to Except for 0.049 mL, the same operation as in Example 1 was carried out to obtain the biodegradable membrane 3 and the acetonitrile-containing membrane 3 .

[0241] These biodegradable films 3 and acetonitrile-containing films 3 were evaluated in the same manner as in Example 1, and the results are shown in Table 1.

[0242] As shown in Table 1, the biodegradab...

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Abstract

The objective of the present invention is to provide a biodegradable material having improved flexibility, an increased percentage of shape recovery after the material has been deformed, and improved biodegradability. The present invention provides a biodegradable material resulting from chemically crosslinking: a polyvalent compound (A) having at least three functional groups (X) such as hydroxyl groups; a polyvalent compound (B) having at least three functional groups such as carboxyl groups; and a compound (C) having a structure derived from a hydroxycarboxylic acid and having a glass transition point of the homopolymerized homopolymer thereof of no greater than -40°C.

Description

technical field [0001] The present invention relates to a biodegradable material and a method for producing the biodegradable material. Background technique [0002] Poly(lactic acid / glycolic acid) copolymers are used as polymer particles for embolization of blood vessels in order to stop bleeding during incision of the affected part, block the nutrient supply to the tumor, maintain the concentration of anticancer agents in the tumor, etc. (Patent Document 1); block copolymers of polyethylene glycol and polylactic acid (Patent Documents 2 to 5); or multi-block copolymers obtained by copolymerizing lactic acid, polyethylene glycol, and polycarboxylic acids (Patent Document 6 ). [0003] Such polymer particles used to embolize blood vessels and the like have a problem in that they cannot be rapidly biodegraded after finishing their role. In addition, spherical particles are used to reliably embolize blood vessels without gaps, but since they are delivered to target sites suc...

Claims

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Application Information

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IPC IPC(8): A61L31/00A61L15/16C08G63/06C08L101/16
CPCA61L24/0042A61L31/148C08L101/16A61L15/64A61L2400/04C08L67/025C08L67/04A61L15/26A61L24/046
Inventor 藤田雅规中西惠棚桥一裕
Owner TORAY IND INC
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