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Method for separating nicotine and TSNA by utilizing electrodialysis process

An electrodialysis method and electrodialysis technology, applied in the field of separation, can solve the problems of lack of comparison and verification elements, unclear TSNA removal effect, etc., and achieve the effect of simple method and convenient operation

Active Publication Date: 2015-01-07
CHINA TOBACCO ANHUI IND CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Since these two inventions lack a key comparative verification element (TSNA content), it is not clear whether they have a removal effect on TSNA

Method used

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  • Method for separating nicotine and TSNA by utilizing electrodialysis process

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] In the present embodiment, the specific steps of the method for separating nicotine and TSNA by electrodialysis are as follows:

[0023] 1) The first electrodialysis desalination treatment

[0024] Adjust the pH value of the mixed solution of nicotine and TSNA to 6.5 by a mixed solution of potassium dihydrogen phosphate and sodium hydroxide (the mass ratio of dipotassium hydrogen phosphate and sodium hydroxide is 11:1), at 10A / cm 2 The nicotine and TSNA can be separated by electrodialysis desalination under constant current density until the voltage drop of the membrane stack reaches a stable value of 50V, and then electrodialysis desalination under the condition of 50V constant voltage until the conductivity is 0.1ms / cm.

[0025] 2) The second electrodialysis desalination treatment

[0026] The pH value of the mixed solution obtained after the first electrodialysis desalination treatment was adjusted to 11.0 by KOH saturated solution, at 10A / cm 2 Under the condition ...

Embodiment 2

[0029] In the present embodiment, the specific steps of the method for separating nicotine and TSNA by electrodialysis are as follows:

[0030] 1) The first electrodialysis desalination treatment

[0031] The pH value of the mixed solution of nicotine and TSNA was adjusted to 6.5 by a mixed solution of potassium dihydrogen phosphate and sodium hydroxide (the mass ratio of dipotassium hydrogen phosphate and sodium hydroxide was 4:1), at 15A / cm 2 The nicotine and TSNA can be separated by electrodialysis desalination under constant current density until the voltage drop of the membrane stack reaches a stable value of 50V, and then electrodialysis desalination under the condition of 50V constant voltage until the conductivity is 0.1ms / cm.

[0032] 2) The second electrodialysis desalination treatment

[0033] The pH value of the mixed solution obtained after the first electrodialysis desalination treatment was adjusted to 12.0 by NaOH saturated solution, at 15A / cm 2 Under the con...

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Abstract

The invention discloses a method for separating nicotine and TSNA by utilizing an electrodialysis process. The method comprises two electrodialysis desalination processes, wherein, in the first electrodialysis desalination treatment, the pH value of a nicotine and TSNA mixed solution is regulated to 6.5-7.5, the electrodialysis desalination treatment is carried out under a condition of constant current density until the voltage is stabilized to be 50V, and then electrodialysis desalination treatment is carried out under a 50V stabilized voltage condition until the electrical conductivity is 0.1ms / cm; in the second electrodialysis desalination treatment, the pH value of the mixed solution obtained after the first electrodialysis desalination treatment is regulated to 10-12, desalination treatment is carried out under the same condition of the first electrodialysis treatment until the electrical conductivity is 0.1ms / cm, and the mixed solution is vaporized and concentrated to obtain high-purity nicotine. The method is simple in process flow and convenient to operate, and is capable of effectively separating TSNA and nicotine and avoiding the problem of environmental pollution and solvent residue caused by usage of organic solvents.

Description

1. Technical field [0001] The invention relates to a separation method, in particular to a method for separating nicotine and TSNA by electrodialysis. 2. Background technology [0002] Nicotine is an important pharmaceutical and chemical raw material, which can be used to produce high-efficiency green pesticides and biological pesticides. one of the important areas. Tobacco-specific nitrosamines (TSNA) are a class of strong carcinogens in tobacco. TSNA in tobacco is the product of nitrosation of tobacco alkaloids such as nicotine, nornicotine, neonicotine, and anatine. Both TSNA and TSNA contain pyridine rings, and their physical and chemical properties are very similar, so the separation of these two types of compounds is difficult. The separation of nicotine and TSNA is an urgent problem to be solved in the preparation of high-purity nicotine, especially medical nicotine. [0003] At present, the preparation of nicotine is mainly extracted from tobacco, mainly including...

Claims

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Application Information

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IPC IPC(8): C07D401/04
CPCC07D401/04
Inventor 葛少林佘世科黄兰张朝朱栋梁徐迎波田振峰陈开波陈闯王宏伟鲍穗张胜军苏瑶
Owner CHINA TOBACCO ANHUI IND CO LTD