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Compound griseofulvin antibacterial medicine

A technology of compound griseofulvin and griseofulvin, which is applied in the field of medicine, can solve the problems of slow antibacterial and bactericidal effects, slow drug dissolution rate, and poor bioavailability, so as to improve the antibacterial effect and bioavailability , the effect of taking convenience

Inactive Publication Date: 2015-01-14
HENAN SOAR VETERINARY PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, there are antifungal drugs such as griseofulvin tablets on the market, and there is no report on the combination of star anise water extract and griseofulvin. Griseofulvin tablets can be eliminated from the gastrointestinal Road absorption but incomplete absorption, slow drug dissolution rate, and poor bioavailability; star anise water extract has good bacteriostatic and bactericidal effects, but it belongs to traditional Chinese medicine, and its bacteriostatic and bactericidal effects are slow. A large number of experiments combined the water extract of star anise and griseofulvin to prepare a compound antibacterial drug containing water extract of star anise and griseofulvin

Method used

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  • Compound griseofulvin antibacterial medicine
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Examples

Experimental program
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Effect test

Embodiment 1

[0032] Compound griseofulvin antibacterial drug, its weight composition is: 6.7 parts of star anise water extract, 30 parts of surfactant (EL-40), 5 parts of co-surfactant (ethanol), 10.2 parts of griseofulvin, oil ( linoleic acid) 13 parts, distilled water 35.1 parts.

[0033] Its preparation method is as follows:

[0034] 1) Weigh griseofulvin 10.2g, EL40 30g, ethanol 5g, star anise water extract 6.7g, linoleic acid 13g and water 35.1g;

[0035] 2) Stir griseofulvin, EL40, linoleic acid and ethanol evenly at room temperature to obtain an oil phase solution;

[0036] 3) Dissolving the star anise water extract in water to obtain an aqueous phase solution;

[0037] 4) Add the water phase solution into the oil phase solution, and stir evenly to obtain the nanoemulsion.

Embodiment 2

[0039] Compound griseofulvin antibacterial drug, its weight composition is: 5.3 parts of star anise water extract, 25 parts of surfactant (EL-40), 15 parts of co-surfactant (1,2-propylene glycol), 9.1 parts of griseofulvin parts, oil (ethyl acetate) 8 parts, distilled water 37.6 parts.

[0040] Its preparation method is with embodiment 1.

Embodiment 3

[0042] Compound griseofulvin antibacterial drug, its weight composition is: 6.4 parts of star anise water extract, 25 parts of surfactant (RH-40), 13 parts of co-surfactant (glycerol), 7.6 parts of griseofulvin, Oil (isopropyl myristate) 10 parts, distilled water 38 parts.

[0043] Its preparation method is with embodiment 1.

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Abstract

The invention provides a compound griseofulvin antibacterial medicine, and belongs to the technical field of medicines. The medicine is nano-emulsion prepared from anise aqueous extract and griseofulvin serving as effective ingredients. The nano-emulsion is mainly prepared from the following components in parts by weight: 1-18 parts of anise aqueous extract, 15-40 parts of a surfactant, 1-18 parts of a co-surfactant, 1-20 parts of griseofulvin, 1-20 parts of oil and 20-70 parts of distilled water; griseofulvin and anise aqueous extract are compounded, the antibacterial capabilities of the griseofulvin and anise aqueous extract can be mutually promoted and improved, and the antibacterial effect is more stable; the nano-emulsion preparation is capable of improving the solubility and permeability of griseofulvin, can be absorbed by lymph system when taken orally, so that the first-pass effect and barrier of molecules passing through gastrointestinal tracts can be overcome, and the bioavailability of the medicine can be improved.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to an oil-in-water nanoemulsion—a compound antibacterial nanoemulsion with star anise water extract and griseofulvin as active ingredients. Background technique [0002] Griseofulvin is white or off-white fine powder; odorless, slightly bitter taste. Griseofulvin can inhibit fungal mitosis, break the mitotic spindle structure, and terminate metaphase cell division. Deposited in the precursor cells of keratin in skin and hair, it can promote keratin to resist the invasion of fungi; when infected keratin falls off, it is replaced by healthy tissue. It is effective against skin fungal infections caused by Epidermophyton, Microsporum and Trichophyton, but not against other fungal infections including Candida and bacteria. [0003] Griseofulvin can be deposited in the stratum corneum of the skin, hair, and nails after being absorbed, and combine with its keratin to prevent...

Claims

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Application Information

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IPC IPC(8): A61K36/57A61K9/107A61P31/10A61K31/343
CPCA61K31/343A61K9/0053A61K9/1075A61K36/57A61K2300/00
Inventor 孙江宏阮心洁王胜乐
Owner HENAN SOAR VETERINARY PHARMA
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