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A kind of pharmaceutical composition for anti-cervical cancer combined with photodynamic therapy

A technology for photodynamic therapy and cervical cancer, applied in the field of medicine, can solve the problem of not finding the biological activity of erythritol against cancer, and achieve the effect of improving targeted killing effect, reducing toxicity and side effects

Inactive Publication Date: 2017-02-15
THE AFFILIATED HOSPITAL OF QINGDAO UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

By searching the literature at home and abroad, there is no literature report that erythritol has anti-cancer or anti-cancer biological activity combined with photodynamic therapy

Method used

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  • A kind of pharmaceutical composition for anti-cervical cancer combined with photodynamic therapy
  • A kind of pharmaceutical composition for anti-cervical cancer combined with photodynamic therapy

Examples

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Comparison scheme
Effect test

Embodiment 1

[0013] Example 1 Study on the Proliferation Inhibitory Rate of Erythritol in Different Concentrations of Human Cervical Cancer Siha and H8 Cells

[0014] Human cervical cancer cell lines Siha and H8 were cultured in RPMI-1640 medium containing 100mL / L calf serum, placed in 37°C, 50mL / L CO 2 , in an incubator with saturated humidity, routinely subcultured with 2.5g / L trypsin. Take the Siha and H8 cells in the logarithmic growth phase, and add erythritol diluted with serum-free RPMI-1640 culture solution after culturing for 24 hours, so that the final concentrations are 1, 5, 10, 20, 40mmol / L respectively . A blank control group with separate culture medium was set up, and each group had 3 replicate wells. Incubate in the incubator in the dark for 24 hours, then discard the culture medium, add 180 μL of fresh serum-free RPMI-1640 culture medium and 20 μL of MTT solution with a concentration of 5 mg / mL to each well, and incubate at 37°C in the dark for 4 hours. Carefully disca...

Embodiment 2

[0019] Example 2 Study on the Proliferation Inhibitory Rate of Erythritol Combined with Photodynamic Therapy on Human Cervical Cancer Siha and H8 Cells

[0020] After the red light (wavelength 630nm, power 300mW) of the photodynamic laser therapy instrument is drawn out through the optical fiber, it irradiates the cells vertically. The experiment was divided into simple erythritol treatment group (ME), simple photodynamic therapy group (PDT), combined erythritol and photodynamic therapy group (ME-PDT).

[0021] Human cervical cancer cell lines Siha and H8 were cultured in RPMI-1640 medium containing 100mL / L calf serum, placed in 37°C, 50mL / L CO 2 , in an incubator with saturated humidity, routinely subcultured with 2.5g / L trypsin. Siha and H8 cells in the logarithmic growth phase of the ME-PDT group were cultured for 24 hours and then added with erythritol diluted with serum-free RPMI-1640 medium to make the final concentrations 10mmol / L respectively. Incubate in the incubat...

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Abstract

The invention discloses a medicine composition for resisting cervical cancer with matching of photodynamic therapy. The medicine composition is prepared from active components and auxiliary materials, wherein the active components include erythritol. According to the medicine composition disclosed by the invention, the erythritol is proposed as an anticancer sensitizing agent used for being matched with the photodynamic therapy for the first time, and synergic effect of anticancer cell proliferation is also acquired, so that a novel treatment thought is provided for clinical medication.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to an anti-cancer medicine, especially a pharmaceutical composition combined with photodynamic therapy to resist cervical cancer and its application. Background technique [0002] Cervical cancer is a malignant tumor second only to breast cancer among women in the world. Its incidence is related to early marriage and early childbearing, sexual disorder and certain viruses transmitted through sexual intercourse (such as human herpesvirus type Ⅱ, human papillomavirus and human cytomegalovirus, etc.) ) are especially associated with infection with HPV types 16 and 18. my country is a big country with cervical cancer incidence and death, with more than 100,000 new cervical cancer patients every year, and more than 200,000 women die of cervical cancer every year in the world. Among young women aged 25-45, cervical cancer deaths rate ranked second. As modern women's sexual c...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K41/00A61K31/047A61P35/00
Inventor 张树超孟萍萍孙波刘鹏周桂花
Owner THE AFFILIATED HOSPITAL OF QINGDAO UNIV
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