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A kind of preparation method of glutathione nano sustained release capsule

A technology of glutathione and nano-sustained release, applied in the fields of genetic engineering and food and medicine, can solve the problems of reduced bioavailability and inactivation, and achieve the effects of safety and environmental protection, low cost and high yield.

Active Publication Date: 2017-09-29
QINGDAO AGRI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0027] The application prospect of glutathione is very broad. However, when glutathione is taken into the body and enters the gastrointestinal digestion, it may be degraded or even inactivated due to the high acidity in the stomach and the action of various enzymes, making its biological Reduced utilization

Method used

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  • A kind of preparation method of glutathione nano sustained release capsule
  • A kind of preparation method of glutathione nano sustained release capsule
  • A kind of preparation method of glutathione nano sustained release capsule

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0080] (1) Preparation of Waxy Corn Starch Short Linear Paste

[0081] Weigh 7.1g disodium hydrogen phosphate and dissolve it in 250ml water, weigh 4.803g citric acid and dissolve it in 250ml water, mix the two, adjust the pH to 4.6; weigh 15g defatted waxy cornstarch and dissolve it in 100ml prepared buffer solution , stirred evenly, treated in a boiling water bath for 40 minutes to make it fully gelatinized; cooled the gelatinized paste to 58°C, added pullulanase, the amount of enzyme added was about 30 aspu / g dry starch, and debranched for 4-6 hours. Centrifuge for 2 minutes to remove part of the undebranched and complete starch chain precipitation to obtain the supernatant; inactivate the enzyme for 15 minutes, then roughly centrifuge for 2 minutes to remove the denatured enzyme

[0082] (2) Preparation of glutathione nano sustained-release capsules

[0083] Cool the waxy cornstarch short amylose paste after the enzyme-inactivated rough centrifugation in step (1) to 50°C ...

Embodiment 2

[0085] (1) Preparation of Waxy Corn Starch Short Linear Paste

[0086] Weigh 7.1g disodium hydrogen phosphate and dissolve it in 250ml water, weigh 4.803g citric acid and dissolve it in 250ml water, mix the two, adjust the pH to 4.6; weigh 10g defatted waxy cornstarch and dissolve it in 100ml prepared buffer solution , stirred evenly, treated in a boiling water bath for 40 minutes to make it fully gelatinized; cooled the gelatinized paste to 58°C, added pullulanase, the amount of enzyme added was about 20 aspu / g dry starch, and debranched for 4-6 hours. Centrifuge for 2 minutes to remove part of the undebranched and complete starch chain precipitates to obtain the supernatant; inactivate the enzyme for 15 minutes, and then roughly centrifuge for 2 minutes to remove the denatured enzyme.

[0087] (2) Preparation of glutathione nano sustained-release capsules

[0088]Cool the waxy cornstarch short amylose paste after the enzyme-inactivated rough centrifugation in step (1) to 50...

Embodiment 3

[0090] (1) Preparation of Waxy Corn Starch Short Linear Paste

[0091] Weigh 7.1g disodium hydrogen phosphate and dissolve it in 250ml water, weigh 4.803g citric acid and dissolve it in 250ml water, mix the two, adjust the pH to 4.6; weigh 20g defatted waxy cornstarch and dissolve it in 100ml prepared buffer solution , stirred evenly, treated in a boiling water bath for 40 minutes to make it fully gelatinized; cooled the gelatinized paste to 58°C, added pullulanase, the amount of enzyme added was about 40aspu / g dry starch, and debranched for 4-6 hours. Centrifuge for 2 minutes to remove part of the undebranched and complete starch chain precipitates to obtain the supernatant; inactivate the enzyme for 15 minutes, and then roughly centrifuge for 2 minutes to remove the denatured enzyme.

[0092] (2) Preparation of glutathione nano sustained-release capsules

[0093] Cool the waxy cornstarch short amylose paste after the enzyme-inactivated rough centrifugation in step (1) to 50...

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Abstract

The invention discloses a preparation method of glutathione nano sustained-release capsules. Nano-starch granules are prepared by a bio-enzyme method. The prepared nano-starch has high yield and low cost, and the method is safer and more environmentally friendly. It is used as an embedding material for glutathione to prepare glutathione nano-sustained-release capsules. The particle size, embedding rate, endothermic properties, crystallinity and digestibility of the nano-sustained-release capsules were measured, and it was found that the digestibility of glutathione in the stomach after nano-starch embedding was low, and the drug was mainly released in the intestinal tract .

Description

technical field [0001] The invention relates to the fields of genetic engineering and food medicine, in particular to a preparation method of glutathione nano sustained-release capsules. Background technique [0002] Glutathione is a tripeptide composed of cysteine, glutamic acid and glycine. The sulfhydryl group on cysteine ​​is its active group, and because it is easy to combine with certain drugs and toxins, it has a certain detoxification effect. Glutathione has a broad-spectrum detoxification ability. It can be used not only in medicine, but also as a base material for functional foods. It has made great progress in delaying aging, improving immunity, and anti-tumor. However, because the reduced glutathione is easily oxidized, the activity is reduced and the health care function is reduced. [0003] Glutathione plays a pivotal role in the biochemical defense system of the human body and has various physiological functions. Its main physiological function is to remove...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K38/06A61K9/52A61K47/36
Inventor 孙庆杰熊柳姬娜刘成珍姜岁岁
Owner QINGDAO AGRI UNIV
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