Surface antibacterial functionalized bone-like apatite-polyurethane bone repair scaffold and preparation method

Abstract

A bone-like apatite-polyurethane bone repair scaffold with antibacterial surface and a preparation method thereof. The bone repair scaffold is covered with mesoporous bismuth with a thickness of 20-500 nanometers, preferably a thickness of 50-200 nanometers, loaded with antibacterial components and a particle size of 20-100 nanometers on the surface of the bone-like apatite-polyurethane porous scaffold. The material layer is composed of silica nanoparticles, and the loading capacity of antibacterial components is 5-50% of the mass of silica nanoparticles. During preparation, place the formed bone-like apatite-polyurethane porous scaffold under negative pressure in the suspension of mesoporous silica loaded with the antibacterial component in the stated proportion and keep it for 0.05 to 3 hours. Take it out and dry it. The surface of the bone repair scaffold is covered with a layer of mesoporous silica nanoparticles loaded with antibacterial components, which can realize the antibacterial functionalization of the surface of the scaffold and the controlled release of antibacterial components, realize the antibacterial infection performance of the scaffold material, and meet the clinical requirements for antibacterial bone. The need for repair materials, and the preparation method is simple.

Description

technical field [0001] The invention relates to a bone-like apatite-polyurethane bone repair bracket with antibacterial surface and a preparation method thereof. Background technique [0002] Biomaterials, as non-living materials for medical objects that interact with biological systems, provide adhesion sites for free bacteria when they are implanted in organisms. As bacteria adhere to the surface of the material, a layer of hydrated polymers is gradually formed. Sugar-like biofilms, in which the drug resistance of bacteria is far greater than that of free bacteria, traditional antibacterial treatments have little effect. Therefore, with the use of implant materials, infections centered on biomaterials are often complicated. Especially in the treatment of infected bone defects caused by chronic osteomyelitis, bone tuberculosis and other chronic bone infections, although thorough debridement and flushing are carried out on the basis of anti-infection, a certain amount of ba...

AI Technical Summary

Problems solved by technology

However, the existing slow-release bone repair materials have the following deficiencies: (1) It is difficult to achieve controlled release of drugs, and it is difficult for local antibacterial drugs to continuously reach an effective antibacterial concentration, and it is difficult to effectively kill local pathogenic bacteria, so that local infection is difficult to control, and even leads to bacterial production. Drug resistance; (2) Biodegradation cannot be performed in vivo or the degradation is not compatible with bone repair, which affects the repair process of bone defects; (3) The long-term release of antibacterial components loaded in the matrix of bone repair materials affects osteogenesis The growth of local bone-like cells is affected, and the release of low-concentration (below the minimum inhibitory concentration) antibiotics in the late release period may also induce bacterial resistance

However, because the drug-loaded microspheres are embedded in the stent matrix, it is difficult to release the drug in the microspheres completely covered by polyurethane. After 36 days, about 30% of the drug still exists in the stent. The long-term slow release of this part of the drug may affect Proliferation of osteoblast-like cells, and later release of low concentrations (below minimum inhibitory concentrations) of antibiotics may also induce bacterial resistance

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