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Application of Cordyceps edulis in the preparation of liver-protecting drugs and health products

A technology of Cordyceps longae and medicine, which is applied in the application field of Cordyceps longae in the preparation of liver-protecting medicines and health care products, and achieves the effects of increasing the content, reducing the degree of cytopathic changes, and reducing the infiltration of inflammatory cells

Active Publication Date: 2018-02-02
ANHUI MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the research on the liver-protecting active extract and active ingredients of Nematode chinensis has not been reported yet.

Method used

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  • Application of Cordyceps edulis in the preparation of liver-protecting drugs and health products
  • Application of Cordyceps edulis in the preparation of liver-protecting drugs and health products
  • Application of Cordyceps edulis in the preparation of liver-protecting drugs and health products

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Embodiment 1: Preparation of the Cordyceps edulis extract

[0027] Grind the fruiting body of Nematode spp. (provided and identified by Professor Li Chunru of Anhui Agricultural University) on a pulverizer, weigh 1.3 kg of powder, soak overnight in 95% ethanol with 5 times the mass of the medicinal material, and heat extract 4 times at 60 ° C, 4 times each time. hours, filtered while hot. The filtrates were combined, ethanol was recovered under reduced pressure to obtain an extract extract, and vacuum-dried at 45° C. to obtain 189 g of an extract of C. elegans. By weight, each component is as follows, sterol content is at 12.3%, cyclic peptide content is at 3.6%, nucleoside content is at 2.5%, polysaccharide content is at 5.6%, mannitol (accounting for 12.9%), trehalose (accounting for 0.5%) ), glucose (3.6%), maltose (1%), amino acids (10%), and other ingredients in 48%.

Embodiment 2

[0028] Embodiment 2: Preparation of the extract of Nematode sinensis

[0029] Grind the fruiting body of Nematode chinensis (provided and identified by Professor Li Chunru of Anhui Agricultural University) on a pulverizer, weigh 1.3kg of powder, soak overnight in water 10 times the mass of the medicinal material, heat extract 4 times at 60°C, 4 hours each time, Strain while hot. The filtrates were combined, concentrated under reduced pressure to obtain an extract extract, and dried in vacuum at 45°C to obtain 260 g of an extract of Nematode sinensis. By weight, each component is as follows, sterol content is at 5%, cyclic peptide content is at 2%, nucleoside content is at 4%, polysaccharide content is at 15%, mannitol (accounting for 25%), trehalose (accounting for 2%) ), glucose (12%), maltose (4%), amino acids (21%), and other ingredients at 10%.

Embodiment 3

[0030] Embodiment 3: Preparation of the extract of Nematode sinensis

[0031] The fruiting body of Nematode sinensis (provided and identified by Professor Li Chunru of Anhui Agricultural University) was pulverized on a pulverizer, 1.3kg of powder was weighed, soaked overnight in 60% ethanol with 8 times the mass of the medicinal material, and reflux extracted 3 times, each time for 3 hours, Filtrate while hot, combine filtrates, recover ethanol under reduced pressure to obtain extract extract, and vacuum dry at 45°C to obtain 310 g of C. By weight, each component is as follows, sterol content is at 17%, cyclic peptide content is at 6%, nucleoside content is at 7%, polysaccharide content is at 12%, mannitol (accounting for 15%), trehalose (accounting for 1%) ), glucose (8%), maltose (3%), amino acids (14%), and other ingredients at 17%.

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Abstract

The invention discloses a preparation method and application of ophiocordyceps longissima (kobayasi) sung and extractive thereof. The ophiocordyceps longissima (kobayasi) sung extractive is extracted from clavicipitaceae ophiocordyceps longissima (kobayasi) sung; the extractive comprises the following components in percentage by weight: 5-25% of sterol, 2-10% of cyclopeptide, 2-10% of nucleoside, 5-25% of polyose, 0.5-5% of trehalose, 1-5% of maltose, 5-25% of amino acid, and 10-80% of balance components. The extractive is prepared by extraction through alcohol aqueous solution, concentration and drying; the ophiocordyceps longissima (kobayasi) sung and the extractive can be used for preparing liver protection medicine or health care products.

Description

technical field [0001] The invention relates to a whole herb of the fungus of the genus Cordyceps, Cordyceps pectoralis and its extract, a preparation method and application thereof, and also relates to a detection method of the extract of the nematodes. Background technique [0002] Liver injury is one of the most common human diseases, which can be caused by many factors, mainly including chemical liver injury, drug-induced liver injury, alcoholic liver injury, immune liver injury and so on. Among them, immune liver injury is usually caused by biological factors, and the common cause is viral infection, such as hepatitis B virus (HBV), hepatitis C virus (HCV) and other viral infections in clinical practice, and its important feature is that the liver A large number of inflammatory cells infiltrate in the tissue and generate an immune / inflammatory response, leading to liver damage based on the immune response, which can further develop into hepatitis, liver fibrosis, liver ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N21/31A61K36/068A61P1/16A23L33/00G01N31/02G01N33/68
CPCA61K36/068A61K2236/331A61K2236/333A61K2236/39G01N21/31G01N30/02
Inventor 程文明李春如李俊王佳佳张勋吴昆
Owner ANHUI MEDICAL UNIV
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