A kind of bamboo ginseng extract and its application

Abstract

The invention provides a panax japonicus extract. The panax japonicus extract is a mixture of panax japonicus saponin IVa, panax japonicus saponin V, panax japonicus saponin IV and panax japonicus saponin Pjs-2 and pharmaceutically acceptable auxiliary materials or carriers, wherein the concentration ratio of the panax japonicus saponin IVa to the panax japonicus saponin V to the panax japonicus saponin IV to the panax japonicus saponin Pjs-2 is (20-28) to (85-95) to (30-40) to (30-45). The invention also provides an application of the panax japonicus extract in preparing a medicament for treating intestinal mucosal injury, wherein the intestinal mucosal injury is caused by non-steroidal anti-inflammatory medicaments. Results show that the panax japonicus saponin IVa and / or total saponins of panax japonicus have / has a treatment effect on the intestinal mucosal injury caused by the non-steroidal anti-inflammatory medicaments.

Description

technical field [0001] The present invention provides a kind of bamboo ginseng extract and application thereof, specifically bamboo ginseng total saponins, including a mixture of bamboo ginseng saponin IVa, bamboo ginseng saponin V, bamboo ginseng saponin IV and bamboo ginsenoside Pjs-2 . Background technique [0002] Non-steroidal anti-inflammatory drugs (NSAIDs) are a class of anti-inflammatory drugs widely used clinically, such as the prevention of cardiovascular and cerebrovascular diseases and the treatment of rheumatic diseases, pain, and sports injuries. In recent years, sustained-release agents and enteric solvents such as diclofenac sodium enteric-coated tablets have been introduced clinically, which can reduce the toxic side effects of gastric damage, but transfer the damage to the distal small intestine; and with the development of capsule endoscopy, NSAID-induced intestinal The diagnosis rate of intestinal injury has increased significantly, and NSAID intestinal...

AI Technical Summary

Problems solved by technology

In recent years, sustained-release agents and enteric solvents such as diclofenac sodium enteric-coated tablets have been introduced clinically, which can reduce the toxic side effects of gastric damage, but transfer the damage to the distal small intestine; and with the development of capsule endoscopy, NSAID-induced intestinal The diagnosis rate of intestinal injury has increased significantly, and NSAID intestinal injury, which has been ignored for a long time, has attracted more and more attention. However, there is no unified and reasonable method for the prevention and treatment of this complication that threatens human health.

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