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A traditional Chinese medicine extract for treating stress hyperglycemia and its preparation method and application

An extract and hyperglycemia technology, which is applied in the field of traditional Chinese medicine extracts and its preparation for the treatment of stress hyperglycemia, can solve the problems of high treatment costs and increased patient suffering, and achieve reduction of medical expenses, improvement of blood sugar levels, and reduction of pathological The effect of the sex effect

Inactive Publication Date: 2018-05-15
THE FIRST AFFILIATED HOSPITAL OF XINXIANG MEDICAL UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the use of insulin intravenous drip treatment not only increases the suffering of patients, but also has high treatment costs.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] The preparation of embodiment 1 Chinese medicine extract

[0017] Take 1060g of raw medicinal materials (125g of fried winter melon seeds, 300g of golden cherry root, 300g of tangerine peel, 150g of Acanthopanax, 35g of Coptis chinensis, and 150g of Polygonatum odoratum), cut them into pieces, add 8.5L of 95% ethanol, and heat and reflux for extraction twice (2h each time) , combine the extracts, filter, and concentrate the filtrate to 500ml under reduced pressure, add 500ml ethyl acetate to it, and extract with ultrasound (frequency 26.4kHz) for 10min, repeat the extraction twice in the same way, combine the ethyl acetate extracts, recover the solvent, and concentrate to the extract, dried in a vacuum drying oven (60° C.), pulverized, and passed through a 100-mesh sieve to obtain the Chinese medicine extract.

Embodiment 2

[0018] Example 2 Effect test of Chinese medicine extract on blood sugar in mice with hyperglycemia induced by adrenaline

[0019] SPF grade Kunming mice, body weight 20-24g, both male and female, were placed in the same laboratory for observation and feeding 3 days before the test, free to eat and drink, and the feed and drinking water of each group were exactly the same. After the test started, all mice were randomly divided into five groups (half male and half male), 10 in each group: normal control group, model control group (distilled water 15ml / kg); positive control group (metformin 0.75g / kg); High and low dosage groups (540 and 270 mg / kg of the Chinese medicine extract prepared in Example 1). All groups were administered intragastrically, once a day, for 10 consecutive days. After fasting for 8 hours before the last administration and 2 hours after administration, each mouse in the other groups was injected with epinephrine 0.5 mg / kg intraperitoneally except for the nor...

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Abstract

The invention discloses a traditional Chinese medicine extract for treating stress hyperglycemia, and a preparation method and application of the traditional Chinese medicine extract. The traditional Chinese medicine extract is prepared from the following traditional Chinese medicine raw materials in parts by weight: 20-32 parts of fried Chinese wax gourd seed, 50-80 parts of cherokee rose root, 50-80 parts of pericarpium citri reticulatae, 20-40 parts of eleutherococcus senticosus, 5-9 parts of coptis chinensis and 18-36 parts of polygonatum odoratum. By orally taking the traditional Chinese medicine extract, the blood glucose level under an abnormal glucose metabolism state caused by hormones such as epinephrine can be improved, the pathological effect on original diseases can be reduced clinically, a patient gets well sooner, and the medical cost of the patient can be reduced.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine extraction, and in particular relates to a traditional Chinese medicine extract for treating stress hyperglycemia, a preparation method and application thereof. Background technique [0002] Stress hyperglycemia occurs in various critically ill patients, such as high fever, acute myocardial infarction, cerebral hemorrhage or cerebral thrombosis, major surgery, trauma such as fractures, severe burns, etc. Due to the stress state, the secretion of glucose-increasing hormones such as adrenaline is relatively high. Normally, the increase is more than 10 times, and the secretion of glucagon, catecholamine, growth hormone, etc. also increases, and the pathological phenomenon of hyperglycemia, urine sugar and impaired glucose tolerance temporarily appears. [0003] Epinephrine is a powerful hormone that raises blood sugar. It binds to the β-receptor on the membrane of liver and muscl...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/8969A61P3/10
CPCA61K36/254A61K36/42A61K36/718A61K36/738A61K36/752A61K36/8969A61K2236/33A61K2236/333A61K2236/51A61K2236/53A61K2300/00
Inventor 陆志红王丽娜周庆兰化秋菊冯红燕
Owner THE FIRST AFFILIATED HOSPITAL OF XINXIANG MEDICAL UNIV
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