Unlock instant, AI-driven research and patent intelligence for your innovation.

Preparation method of phytic acid/hydroxyapatite hybrid coating on magnesium alloy

A technology of hydroxyapatite and magnesium alloy, which is applied in metal material coating process, coating, medical science, etc., can solve the problems of not involving film forming process, lack of biological activity, low interface strength, etc., and achieve short preparation cycle , Improve biological activity, uniform and dense coating surface

Inactive Publication Date: 2016-10-05
TIANJIN UNIV
View PDF5 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Chinese patent CN 102085388A reports a preparation method of a hybrid coating containing polypeptide chain segments prepared by layer-by-layer (LBL) technology, which is suitable for surface modification of titanium-based materials for various hard tissue repairs in vivo , but the process is complex and the preparation cycle is long
Chinese patent CN 101987919A introduces a preparation method of nano-TiO2 sol hybrid coating, the prepared coating has stable performance, but does not involve the detailed film-forming process on the substrate
In summary, a single organic polymer coating, such as an environmentally friendly phytic acid conversion coating, although degradable after implantation in the human body, lacks biological activity.
The organic-inorganic hybrid coating prepared by dipping and pulling process, because of the physical bonding between the coating and the substrate, the interface strength is not high, and the coating is easy to fall off

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Preparation method of phytic acid/hydroxyapatite hybrid coating on magnesium alloy
  • Preparation method of phytic acid/hydroxyapatite hybrid coating on magnesium alloy
  • Preparation method of phytic acid/hydroxyapatite hybrid coating on magnesium alloy

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Step 1: Preparation of hydroxyapatite powder

[0020] Synthesis of hydroxyapatite by sol-gel method: Accurately weigh 3.941g Ca (NO 3 ) 2 4H 2 O and 0.71gP 2 o 5 . Ca(NO 3 ) 2 4H 2 Aqueous solution of O: Dissolve the weighed soluble calcium salt in 10ml of deionized water, and stir thoroughly for 10-15 minutes to obtain a colorless and transparent solution A with a concentration of 1.67mol / L; then prepare P 2 o 5 ethanol solution: the weighed P 2 o 5 Slowly add the powder into 10ml of absolute ethanol, and fully stir for 30-45min to obtain a phosphorus-based precursor alcohol solution B with a concentration of 1.00mol / L. Add solution B to solution A at a rate of 30-40 drops per minute, stir for 40-60 minutes, let it stand for 24 hours, dry the obtained gel at 60°C for 24 hours, grind it fully in a mortar, and finally The obtained powder was heat-treated at 600° C. for 4 hours to obtain hydroxyapatite powder.

[0021] Step 2: Preparation of hybrid coating

[...

Embodiment 2

[0028] Step 1: Preparation of hydroxyapatite powder

[0029] Synthesis of hydroxyapatite by sol-gel method: According to the Ca / P molar ratio of 1.67 in the composition of hydroxyapatite, accurately weigh 5.544g Ca-EDTA and 0.71gP 2 o 5 . First prepare the aqueous solution of Ca-EDTA: dissolve the weighed soluble calcium salt in 10ml of deionized water, and stir thoroughly for 10-15 minutes to obtain a colorless and transparent solution A with a concentration of 1.67mol / L; then prepare P 2 o 5 ethanol solution: the weighed P 2 o 5 Slowly add the powder into 10ml of absolute ethanol, and fully stir for 30-45min to obtain a phosphorus-based precursor alcohol solution B with a concentration of 1.00mol / L. Add solution B to solution A at a rate of 30-40 drops per minute, stir for 40-60 minutes, let it stand for 48 hours, dry the obtained gel at 60°C for 24 hours, grind it fully in a mortar, and finally The obtained powder was heat-treated at 600° C. for 4 h to prepare hydroxy...

Embodiment 3

[0034] Step 1: Preparation of hydroxyapatite powder

[0035] Synthesis of hydroxyapatite by sol-gel method: Accurately weigh 3.941g Ca (NO 3 ) 2 4H 2 O and 0.71gP 2 o 5 . Ca(NO 3 ) 2 4H 2 Aqueous solution of O: Dissolve the weighed soluble calcium salt in 10ml of deionized water, and stir thoroughly for 10-15 minutes to obtain a colorless and transparent solution A with a concentration of 1.67mol / L; then prepare P 2 o 5 ethanol solution: the weighed P 2 o 5 Slowly add the powder into 10ml of absolute ethanol, and fully stir for 30-45min to obtain a phosphorus-based precursor alcohol solution B with a concentration of 1.00mol / L. Add solution B to solution A at a rate of 30-40 drops per minute, stir for 40-60 minutes, let it stand for 48 hours, dry the obtained gel at 80°C for 48 hours, grind it thoroughly, and finally put the powder at 550 ℃ heat treatment for 4h to prepare hydroxyapatite powder.

[0036] Step 2: Preparation of hybrid coating

[0037] Take the phy...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
thicknessaaaaaaaaaa
quality scoreaaaaaaaaaa
Login to View More

Abstract

The invention relates to a preparation method of an organic-inorganic hybrid coating on the surface of a magnesium alloy. The hybrid coating is obtained by in-situ growth on the magnesium alloy matrix and is well bonded to the interface of the matrix. The hybrid coating is prepared by the hybridization of a magnesium phytate chemical conversion film and hydroxyapatite; the coating is uniform and dense, and is 0.6-1.0 micron thick. The coating material integrates advantages of organic and inorganic matters, and not only can be used for effectively improving the corrosion resistance of the magnesium alloy and controlling the degradation rate of the magnesium alloy, but also can be used for remarkably improving the bioactivity with the addition of the hydroxyapatite; and the hybrid coating can be used for rapidly inducing the formation and the growth of new bone on the surface of an implant.

Description

technical field [0001] The invention relates to a method for preparing a phytic acid / hydroxyapatite hybrid coating on a magnesium alloy, and belongs to the technical field of preparation of biomedical coating materials. Background technique [0002] At present, the medical metal implant materials that have been used clinically mainly include three categories: stainless steel, cobalt-based alloys and titanium-based alloys, all of which are biologically inert materials. After clinical application, the above-mentioned medical metal materials have shown some disadvantages, such as wear debris generated by friction in the body and soluble ions generated by corrosion in the body fluid environment. These wear debris and soluble ions will produce certain biological toxicity, cause local allergic reaction or inflammation, and even lead to implant failure. In addition, these medical metal materials are all non-degradable materials. For short-term implant materials, after the body's o...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/32A61L27/50C23C22/57C23C24/00
Inventor 蔡舒张敏李妍申偲伯张同
Owner TIANJIN UNIV