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A kind of pamam-modified water-soluble upconversion nanoparticles and preparation method thereof

A nanoparticle, water-soluble technology, applied in the field of nanomaterials, can solve the problems of poor water solubility and biocompatibility, limited application, etc., and achieve the effects of good water solubility, high luminous intensity, and good application prospects.

Active Publication Date: 2016-06-22
淮南市新光源特种照明器材有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, most of these methods obtain oil-soluble UCNPs, which have poor water solubility and biocompatibility, which limits their application in biomedicine and other fields, so it is necessary to modify the surface of nanoparticles after synthesis.

Method used

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  • A kind of pamam-modified water-soluble upconversion nanoparticles and preparation method thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] 0.78mmol of YCl 3 , 0.2mmol of YbCl 3 , 0.02mmol of ErCl 3 5mL of methanol solution, 6mL of oleic acid OA and 15mL of 1-octadecene ODE were ultrasonically mixed, heated to 150°C under argon protection, and kept for 30 minutes to form a light yellow solution, then cooled to 50°C C, add NH containing 0.16g ammonium fluoride 4 F and 0.10g NaOH in methanol solution, ultrasonic for 30 minutes, then slowly heated to 110°C and maintained for 1h to remove methanol and residual water, then heated to 320°C at a speed of 1°C / min under argon protection, Keep for 2 hours, then naturally cool to room temperature, add absolute ethanol, centrifuge to obtain a precipitate, and then repeatedly wash with water and ethanol to finally obtain upconversion nanoparticles that can be dissolved in cyclohexane.

[0021] Mix 1g / L of 5mL up-converting luminescent nanoparticles hexane dispersion solution with 0.6g / L of 5mL nitrosonium tetrafluoroborate NOBF 4 The dichloromethane solution was mix...

Embodiment 2

[0024] 0.69 mmol YCl 3 , 0.3mmol of YbCl 3 , 0.01mmol of ErCl 3 5mL of methanol solution, 6mL of oleic acid OA and 15mL of 1-octadecene ODE were ultrasonically mixed, heated to 150°C under argon protection, and kept for 30 minutes to form a light yellow solution, then cooled to 50°C C, add NH containing 0.16g ammonium fluoride 4 F and 0.10g NaOH in methanol solution, ultrasonic for 30 minutes, then slowly heated to 110°C and maintained for 1h to remove methanol and residual water, then heated to 320°C at a speed of 1°C / min under argon protection, Keep for 2 hours, then naturally cool to room temperature, add absolute ethanol, centrifuge to obtain a precipitate, and then repeatedly wash with water and ethanol to finally obtain upconversion nanoparticles that can be dissolved in cyclohexane.

[0025] Mix 2g / L of 5mL up-converting luminescent nanoparticles hexane dispersion solution with 0.3g / L of 5mL nitrosonium tetrafluoroborate NOBF 4 The dichloromethane solution was mixed...

Embodiment 3

[0027] 0.78mmol of YCl 3 , 0.2mmol of YbCl 3 , 0.02mmol of TmCl 35mL of methanol solution, 6mL of oleic acid OA and 15mL of 1-octadecene ODE were ultrasonically mixed, heated to 150°C under argon protection, and kept for 30 minutes to form a light yellow solution, then cooled to 50°C C, add NH containing 0.16g ammonium fluoride 4 F and 0.10g NaOH in methanol solution, ultrasonic for 30 minutes, then slowly heated to 110°C and maintained for 1h to remove methanol and residual water, then heated to 320°C at a speed of 1°C / min under argon protection, Keep for 2 hours, then naturally cool to room temperature, add absolute ethanol, centrifuge to obtain a precipitate, and then repeatedly wash with water and ethanol to finally obtain upconversion nanoparticles that can be dissolved in cyclohexane.

[0028] Mix 2g / L of 5mL up-converting luminescent nanoparticles hexane dispersion solution with 0.6g / L of 5mL nitrosonium tetrafluoroborate NOBF 4 The dichloromethane solution was mixe...

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Abstract

The invention discloses PAMAM (polyamide-amine)-modified water-soluble upconversion nanoparticles and a preparation method thereof. The preparation method comprises the following steps: synthesizing hexagonal-phase upconversion light-emitting nanoparticles (UCNPs) by high-temperature thermal decomposition, treating the UCNPs with nitronium tetrafluoroborate to substitute the oleic acid molecule on the surface, and finally, reacting with PAMAM to obtain the PAMAM-modified water-soluble upconversion nanoparticles. The prepared water-soluble upconversion nanoparticles have the advantages of high water solubility and high luminescent intensity; the surface is provided with the active amino group capable of coupling with biomacromolecule; and thus, the water-soluble upconversion nanoparticles have favorable application prospects in the fields of biological imaging, fluorescence labeling, drug carriers and the like.

Description

technical field [0001] The invention relates to a PAMAM-modified water-soluble up-conversion nano particle and a preparation method thereof, belonging to the field of nano-materials. Background technique [0002] Rare-earth up-conversion luminescent material Up-conversion (UC) is a luminescent material that emits visible light under near-infrared light excitation, which can convert long-wave radiation into short-wave radiation through a multi-photon mechanism. This material emits light against Stokes' law, so it is also called anti-Stokes' law luminescent material. UC luminescence is based on the transition between 4f electrons of rare earth elements. The luminescence process can be divided into three steps: ① matrix lattice absorbs excitation energy; ② matrix lattice transfers the absorbed excitation energy to excited ions to make them excited; ③ excited rare earth ions emit fluorescence and return to the matrix. There are four main types of upconversion processes: excite...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C09K11/85C09K11/02
Inventor 赵兵
Owner 淮南市新光源特种照明器材有限公司