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A multi-microtube reactor for continuous preparation of carrier particles

A technology of carrier particles and microtubes, applied in chemical/physical/physical-chemical reactors, chemical instruments and methods, chemical/physical/physical-chemical processes, etc., can solve the difficulties of microchannel reactor amplification and large-scale preparation, etc. problems, to achieve the effect of easy processing and manufacturing, simple design and structure, and wide application prospects

Active Publication Date: 2016-04-13
ZHEJIANG UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the existing microchannel reactors are not easy to scale up, and large-scale preparation is still difficult

Method used

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  • A multi-microtube reactor for continuous preparation of carrier particles

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Example 1 The present invention takes 316 stainless steel as the material of described multi-microcapillary reactor, gets long 40mm, Ф The 19×1.5mm 90-degree stainless steel clamp quick-loading elbow is used as the inlet section of the multi-microtube reactor to facilitate connection; the round table diversion section is stamped and formed by a mold, and is obtained by polishing. The wall thickness is 1.5mm, and its total height 142mm, side edge length 131mm; the top end is connected to the inlet section through a clamp joint; the bottom end is welded with a flange with an outer diameter of 180mm, a thickness of 9mm, and a central through hole that matches the fluid distributor; the fluid distributor section is composed of a high 20mm, inner diameter Ф The 109×2mm stainless steel cylinder is composed of a 9mm thick stainless steel distributor disk matching its inner diameter. There are 97 uniformly distributed small holes on the distributor disk. Ф 2mm, so that th...

Embodiment 3

[0027] Example 3 With the same other dimensions as in Example 1 but small holes on the disc of the distributor Ф 4mm, micro tube size Ф The 2.8×0.3mm stainless steel multi-microtube reactor is used as the application object, with 2% (w / w) sodium alginate as the aqueous solution as the reaction solution, 10% CaCl 2 The solution is a cross-linking agent, and the immobilized carrier is continuously prepared at a flow rate of 120mL / min. The particle size of the porous carrier particles obtained through pore formation is 3.4±0.1mm.

Embodiment 4

[0028] Example 4 With the same other dimensions as in Example 1 but small holes on the disc of the distributor Ф 4mm, micro tube size Ф The 2.8×0.3mm stainless steel multi-microtube reactor is used as the application object, and the sodium alginate (2%, w / w) suspension containing 0.5% (w / w) brewer’s yeast cells is used as the reaction liquid, and 10% CaCl 2 The solution is a cross-linking agent, and the immobilized carrier is continuously prepared at a flow rate of 120mL / min, and the particle diameter of the microbe-immobilized porous carrier particles obtained through pore formation is 3.5±0.1mm.

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Abstract

The invention discloses a multi-microtube reactor for continuous preparation of carrier particles, which is mainly composed of an inlet pipe section, a circular platform diversion section, a fluid distributor section, a multi-microtube section and the like. The fluid reaction liquid enters the reactor from the inlet pipe section, and after being drained by the circular platform diversion section and distributed by the fluid distributor section, it flows out from the multi-micro pipe section to form reactable droplets with relatively uniform diameters, which undergo corresponding cross-linking reactions or polymerization reactions. After pores, porous carrier particles are formed. The reactor has a simple design and structure, is easy to process, and is easy to implement in the manufacturing process. It can be used to prepare carrier particles with uniform particle size, and has wide application prospects in the fields of bioengineering, pharmaceutical dosage forms, material engineering, chemical engineering, and biomedical engineering.

Description

technical field [0001] The invention belongs to the technical field of chemical machinery equipment, and in particular relates to a multi-microtube reactor for continuously preparing carrier particles. Background technique [0002] Porous carrier particles have important applications in many fields such as bioengineering, material engineering, chemical engineering, pharmaceuticals, and biomedical engineering. Common carrier particles include microbial immobilization carrier particles, biological separation media, drug carriers, tissue engineering scaffold particles, etc. These carrier particles not only need to have a certain distribution of pores, but also need a uniform particle size. [0003] However, it is difficult to prepare carrier particles with uniform particle size. In recent years, based on the method of microfluidic forming, the controllable preparation of carrier particles can be achieved through microchannels, and carrier particles with uniform particle size c...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B01J19/00
CPCB01J19/0053B01J19/0093B01J2219/00013B01J2219/00033B01J2219/00792B01J2219/00855B01J2219/00869
Inventor 张玮陈冰冰郑三龙杨玉军徐林红
Owner ZHEJIANG UNIV OF TECH