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Treatment of Inflammatory Bowel Disease

A pharmaceutical and clinoptilolite technology, applied in anti-inflammatory agents, inorganic active ingredients, non-central analgesics, etc., can solve problems such as unpleasant side effects and limited use

Active Publication Date: 2019-03-01
GLOCK HEALTH SCI & RES GMBH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, these drugs cause a variety of serious, unpleasant side effects, so they have only limited use

Method used

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  • Treatment of Inflammatory Bowel Disease
  • Treatment of Inflammatory Bowel Disease
  • Treatment of Inflammatory Bowel Disease

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0029] The efficacy and harmlessness of the substances according to the invention are demonstrated by the analyzes and tests set forth below.

[0030] For five groups of 12 mice each (only 3 mice in the control group), the usual experimental procedure for the treatment of IBD, induced by administration of dextran sulfate sodium (DSS), was performed. This consisted of administering DSS in drinking water for five days (with the exception of the control group), followed by oral administration of each specific test substance. On the tenth day, using CO 2 Mice were sacrificed and colons were removed for examination. The groups are as follows:

[0031] group 1 : Control group, not receiving any DSS, only three mice, compared to 12 mice each in the other groups.

[0032] group 2 : Only accept DSS.

[0033] group 3 : (GHC1) received DSS as described above, and from the sixth day onwards received heavy metal-depleted clinoptilolite ground to an average particle size of 3.5 μm...

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Abstract

The present invention relates to the treatment of inflammatory bowel disease (also known as IBD), including ulcerative colitis and Crohn's disease. For this purpose, the present invention provides clinoptilolite with a particle size of 0.2-1 μm for use in the treatment of inflammatory bowel disease (also known as IBD) in mammals and humans. In the case of this application, the clinoptilolite is preferably free of heavy metals. In one variant, it is administered orally, optionally with pharmaceutically harmless carrier materials and / or diluents.

Description

field of invention [0001] According to the preamble of claim 1 , the present invention relates to the treatment of inflammatory bowel diseases (also called IBD), including ulcerative colitis and Crohn's disease. Background technique [0002] WO2010 / 061355 discloses the oral administration of clinoptilolite "for the treatment of various human medical conditions". In such treatments, a specially pretreated clinoptilolite called "potentiated clinoptilolite" is used. The conditions to be treated mentioned in the description also include IBS, which is an acronym for "Irritable Bowel Syndrome", a condition quite different from IBD. [0003] IBS is a diagnosis of exclusion that is not made directly by targeted investigations, but results from the systematic exclusion of other causes of the condition. It can be said to be the negative intersection of all possible diagnoses; it is an "insignificant", predicted benign, high prevalence condition that is neither life-threatening nor l...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K33/00A61P1/00
CPCA61K33/06A61K33/08A61P1/00A61P1/04A61P29/00A61P39/00
Inventor G·格洛克
Owner GLOCK HEALTH SCI & RES GMBH