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Preparation method of soluble starch nanoparticle-insulin sustained-release capsule

A technology of starch nano and slow-release capsules, which is applied in the direction of medical preparations containing active ingredients, pharmaceutical formulas, metabolic diseases, etc. It can solve the problems of affecting the extraction of the main drug, difficulty in granulation, and quality impact, etc., to achieve low cost, Good sliding properties and high embedding rate

Inactive Publication Date: 2015-06-03
QINGDAO GREAT CONSTR INSTALLATION ENG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

When dextrin is used as a diluent, it often affects the extraction of the main drug during the determination of the amount, and it will also affect the quality of some
When dextrin is used as a granule, it is not easy to granulate due to its high viscosity

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] The preparation method of soluble starch nanoparticle-insulin slow-release capsule is characterized in that it specifically comprises the following steps:

[0017] (1) Preparation of buffer solution: Take out 3ml of sodium hydrogen phosphate and citric acid and dissolve in 100ml of distilled water according to the weight ratio of 5:3, stir to dissolve fully, and set aside;

[0018] (2) Starch oxidation treatment: Choose cornstarch that is ventilated and dried for 12 hours at 40°C, crushed, and passed through a 120-mesh sieve, and spray 6% hydrogen peroxide solution into the cornstarch with a moisture mass fraction of 15% while stirring, and stir. After 5min, spray 0.04% FeSO 4 Solution, stirred for 8min;

[0019] (3) Starch gelatinization: Add 10% oxidized starch, 0.2% pullulanase, and 0.2% cellulase to the prepared buffer solution, and place it in an 85°C water bath for 40 minutes to make the starch completely Gelatinization, then cooling down to 60°C;

[0020] (4) ...

Embodiment 2

[0023] The preparation method of soluble starch nanoparticle-insulin slow-release capsule is characterized in that it specifically comprises the following steps:

[0024] (1) Preparation of buffer solution: Take out 3ml of sodium hydrogen phosphate and citric acid and dissolve in 100ml of distilled water according to the weight ratio of 5:3, stir to dissolve fully, and set aside;

[0025] (2) Starch oxidation treatment: Choose cornstarch that is ventilated and dried for 12 hours at 40°C, crushed, and passed through a 120-mesh sieve, and spray 7% hydrogen peroxide solution into the cornstarch with a moisture mass fraction of 18% while stirring, and stir. After 6min, spray 0.05% FeSO 4 Solution, stirred for 10min;

[0026] (3) Starch gelatinization: add 11% oxidized starch, 0.3% pullulanase, and 0.2% cellulase to the prepared buffer solution, and place it in an 88°C water bath for 38 minutes to make the starch completely Gelatinization, then cooling down to 60°C;

[0027] (4)...

Embodiment 3

[0030] The preparation method of soluble starch nanoparticle-insulin slow-release capsule is characterized in that it specifically comprises the following steps:

[0031] (1) Preparation of buffer solution: Take out 3ml of sodium hydrogen phosphate and citric acid and dissolve in 100ml of distilled water according to the weight ratio of 5:3, stir to dissolve fully, and set aside;

[0032] (2) Starch oxidation treatment: Choose cornstarch that is ventilated and dried for 12 hours at 40°C, crushed, and passed through a 120-mesh sieve, and spray 8% hydrogen peroxide solution into the cornstarch with a moisture mass fraction of 20% while stirring, and stir. After 7min, spray 0.06% FeSO 4 Solution, stirred for 12min;

[0033] (3) Starch gelatinization: Add 12% oxidized starch, 0.4% pullulanase, and 0.3% cellulase to the prepared buffer solution, and place it in a 90°C water bath for 35 minutes to make the starch completely Gelatinization, then cooling down to 60°C;

[0034] (4) ...

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Abstract

The invention discloses a preparation method of a soluble starch nanoparticle-insulin sustained-release capsule. The method is characterized by specifically comprising the following steps: (1) preparing a buffer solution; (2) carrying out starch oxidation treatment; (3) pasting starch; (4) carrying out centrifugal enzyme deactivation; and (5) adding an insulin solution. The soluble starch prepared by the preparation method is good in sliding property; by virtue of a gelatinized debranched starch suspension, the action effect of enzyme is relatively mild, and the reaction conditions are easy to control; the insulin solution is added, so that the insulin solution is embedded into a double-helix cavity of amylose in the crystallization processes of debranched amylose to obtain the soluble starch nanoparticle-insulin sustained-release capsule. According to the obtained soluble starch nanoparticle-insulin sustained-release capsule, the starch nanoparticle is small in particle size and large in specific surface area, and has the advantages of high embedding rate on transported medicines, safety, no toxic or side effect, small hygroscopicity, low cost and the like, so that the medicines are easily packed into the capsule; the preparation technology is relatively simple; and the slow-release effect of the capsule is good.

Description

technical field [0001] The invention belongs to the technical field of preparation of sustained-release capsules, and in particular relates to a preparation method of soluble starch nanoparticle-insulin sustained-release capsules. technical background [0002] Insulin, as a protein, will be decomposed by protease when taken directly orally, and cannot achieve the effect of controlling blood sugar levels. Therefore, it is necessary to find a carrier that can load insulin. The principle of oral insulin preparations is to embed insulin into a carrier and enter the human body through oral administration. This carrier can effectively not be decomposed by gastrointestinal fluid in the body, and release insulin efficiently into the blood, thereby achieving hypoglycemic effect. The advantage of oral insulin administration is that it greatly reduces the pain of injection for the patient, the dosage of the drug is small, the duration of the drug effect is long, and the time of the dr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/28A61K9/52A61K47/36A61P3/10
Inventor 王超张炳龙
Owner QINGDAO GREAT CONSTR INSTALLATION ENG
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