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A kind of pharmaceutical composition containing candesartan cilexetil

A technology of candesartan cilexetil and composition, which is applied in the field of preparation of pharmaceutical compositions and tablets thereof, can solve problems such as the decomposition of candesartan cilexetil, achieve complete dissolution, simple and easy production operation, and good stability Effect

Active Publication Date: 2017-12-19
长春海悦药业股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Candesartan cilexetil is sensitive to heat and moisture, and a small amount of water in the preparation of oral preparations may also cause the decomposition of candesartan cilexetil

Method used

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  • A kind of pharmaceutical composition containing candesartan cilexetil
  • A kind of pharmaceutical composition containing candesartan cilexetil
  • A kind of pharmaceutical composition containing candesartan cilexetil

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0072] prescription

[0073] Candesartan cilexetil 10g

[0074] Anhydrous lactose 50g

[0075] dry starch 4g

[0076] Micronized silica gel 1.8g

[0077] Aluminum phosphate 13.6g.

[0078] Preparation

[0079] (1) After mixing 10 g of candesartan cilexetil and 50 g of anhydrous lactose, carry out microwave vacuum drying;

[0080] (2) crush the mixture of candesartan cilexetil and anhydrous lactose obtained in step (1), pass through an 80-mesh sieve, and set aside;

[0081] (3) After passing 13.6g of aluminum phosphate, 4g of dry starch, and 1.8g of micropowdered silica gel through an 80-mesh sieve, set aside;

[0082] (4) Pour the aluminum phosphate, dry starch, micropowder silica gel sieved in step (3), and the mixture obtained in step (2) into a mixer for mixing;

[0083] (5) The mixture in step (4) is crushed at a low temperature and at a slow speed, and passed through a 80-mesh sieve;

[0084] (6) The granules obtained in step (5) are directly compressed into table...

Embodiment 2

[0086] prescription

[0087] Candesartan cilexetil 15g

[0088] Anhydrous Lactose 45g

[0089] Sodium carboxymethyl starch 8g

[0090] Talc powder 2.8g

[0091] Aluminum phosphate 12.0g.

[0092] Preparation

[0093] (1) After mixing 15g of candesartan cilexetil and 45g of anhydrous lactose, carry out microwave vacuum drying;

[0094] (2) crush the mixture of candesartan cilexetil and anhydrous lactose obtained in step (1), pass through an 80-mesh sieve, and set aside;

[0095] (3) 12g aluminum phosphate, 8g sodium starch glycolate, and 2.8g talcum powder are passed through an 80-mesh sieve respectively, and set aside;

[0096] (4) The aluminum phosphate, sodium carboxymethyl starch, and talcum powder sieved in step (3), and the mixture obtained in step (2) are poured into a mixer for mixing;

[0097] (5) The mixture in step (4) is crushed at a low temperature and at a slow speed, and passed through a 80-mesh sieve;

[0098] (6) The granules obtained in step (5) are di...

Embodiment 3

[0100] prescription

[0101] Candesartan cilexetil 20g

[0102] Anhydrous Lactose 40g

[0103] Low-substituted hydroxypropyl cellulose 12g

[0104] Micronized silica gel 2.5g

[0105] Aluminum phosphate 12.8g.

[0106] Preparation

[0107] (1) After mixing 20g of candesartan cilexetil and 40g of anhydrous lactose, carry out microwave vacuum drying;

[0108] (2) crush the mixture of candesartan cilexetil and anhydrous lactose obtained in step (1), pass through a 100-mesh sieve, and set aside;

[0109] (3) After passing 12.8g of aluminum phosphate, 12g of low-substituted hydroxypropyl cellulose, and 2.5g of micropowder silica gel through a 100-mesh sieve, set aside;

[0110] (4) Pour the sieved aluminum phosphate, low-substituted hydroxypropyl cellulose, micronized silicon, and the mixture obtained in step (2) into a mixer for mixing;

[0111] (5) The mixture in step (4) is pulverized at a low temperature and slowly, and passed through a 100-mesh sieve;

[0112] (6) The ...

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PUM

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Abstract

The invention belongs to the technical field of medicine, and in particular relates to a pharmaceutical composition containing candesartan cilexetil, which contains candesartan cilexetil, a disintegrant, a lubricant, anhydrous lactose and aluminum phosphate. The product of the present invention has good stability, complete stripping, and more excellent product quality; the product of the present invention is simple and easy to operate and is suitable for industrial production.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a pharmaceutical composition containing candesartan cilexetil and a preparation method of a tablet thereof. Background technique [0002] Candesartan is a new type of angiotensin II receptor antagonist, which selectively blocks the action of AngII in circulation and tissues, and has a significant antihypertensive effect. Candesartan cilexetil is the prodrug of candesartan, which can be completely hydrolyzed in the gastrointestinal tract and converted into candesartan with antihypertensive activity. [0003] Candesartan cilexetil is white or off-white crystalline powder; easily soluble in chloroform, soluble in acetone, slightly soluble in methanol, slightly soluble in ethanol, almost insoluble in water. Candesartan cilexetil is sensitive to heat and moisture, and a small amount of water in the preparation of oral preparations may also cause the decomposition of cand...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/20A61K31/4184A61K47/04A61P9/12
Inventor 田晶王小雪张春苗徐璐
Owner 长春海悦药业股份有限公司