Finasteride tablet for treating hyperplasia of prostate and preparation method of finasteride tablet

A technology for prostatic hyperplasia and androsterine tablets, which is applied in the directions of non-active ingredients medical preparations, medical preparations containing active ingredients, and pill delivery, etc. problem, to achieve the effect of simple preparation process, easy operation and rapid dissolution

Active Publication Date: 2015-07-01
优标易站(苏州)电子商务有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

As we all know, the crystal form of a compound is directly related to its solubility, product stability, and product efficacy. It is an effective way to increase the solubility of insoluble compounds through organic solvents, but it is necessary to always pay attention to the stability ...

Method used

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  • Finasteride tablet for treating hyperplasia of prostate and preparation method of finasteride tablet
  • Finasteride tablet for treating hyperplasia of prostate and preparation method of finasteride tablet
  • Finasteride tablet for treating hyperplasia of prostate and preparation method of finasteride tablet

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028]

[0029]Preparation Process:

[0030] Dissolve finasteride in caprylic capric acid macrogol glyceride, add γ-cyclodextrin for adsorption, sieve through a 18-mesh sieve, and mix with microcrystalline cellulose PH112, crospovidone, stearic acid The magnesium is mixed evenly, and the Φ7.5mm shallow arc punching tablet is pressed, and the product is obtained.

Embodiment 2

[0032]

[0033] Preparation Process:

[0034] Dissolve finasteride in caprylic capric acid macrogolglyceride, add γ-cyclodextrin for adsorption, sieve through a 18-mesh sieve, and mix with microcrystalline cellulose PH112, polacrilin potassium, aluminum magnesium silicate Mix evenly, punch Φ8mm shallow-arc tablets, and get ready.

Embodiment 3

[0036]

[0037] Preparation Process:

[0038] Dissolve finasteride in caprylic capric acid macrogol glyceride, add γ-cyclodextrin for adsorption, sieve through a 18-mesh sieve for granulation, and mix with lactose, sodium starch glycolate, sodium stearate fumarate Mix evenly, punch Φ9mm shallow-arc tablets, and get ready.

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PUM

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Abstract

The invention discloses a finasteride tablet for treating hyperplasia of prostate and a preparation method of the finasteride tablet. The tablet is obtained by compressing medicine-containing particles and pharmaceutically acceptable auxiliary materials, wherein the medicine-containing particles are prepared by following steps: dissolving finasteride in polyethylene glycol glyceride octoate decanoate, adding gamma-cyclodextrin into the solution to perform adsorption and then screening to obtain the medicine-containing particles. The finasteride tablet prepared by the preparation method is high in dissolving speed, and the dissolving amount of the finasteride tablet can be higher than 95% in 5 minutes; moreover, the preparation method has the advantages of simple process and easy operation.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, and in particular relates to a pharmaceutical preparation for treating benign prostatic hyperplasia, in particular to a finasteride-containing tablet and a preparation method thereof. Background technique [0002] Benign prostatic hyperplasia (BPH) is one of the common and frequent male senile diseases. According to statistics, the incidence rate of BPH in elderly men over 50 years old is about 30%-50%, about 70% for those aged 70-79, and over 90% for those over 80 years old. Because benign prostatic hyperplasia narrows the urethra and causes voiding disorders, BPH is the main cause of urgency, frequency, and dysuria in older men. These symptoms seriously affect the quality of life of the patient, and if not treated in time, it will lead to many serious complications (such as acute urinary retention, stones, renal insufficiency, etc.), and even endanger the life of the patien...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K31/58A61K47/40A61K47/34A61P13/08
Inventor 王菊明
Owner 优标易站(苏州)电子商务有限公司
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