Unlock instant, AI-driven research and patent intelligence for your innovation.

Receptacle and system for optically analyzing a sample without optical lenses

An optical analysis and sample technology, applied in the field of optical analysis sample system, can solve the problem of CMOS image sensor contamination and other problems

Active Publication Date: 2015-07-22
FRAUNHOFER GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG EV
View PDF11 Cites 7 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, CMOS image sensors are contaminated by direct contact with cell culture

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Receptacle and system for optically analyzing a sample without optical lenses
  • Receptacle and system for optically analyzing a sample without optical lenses
  • Receptacle and system for optically analyzing a sample without optical lenses

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0048] figure 1 A system for optical analysis of a biological sample, such as a cell culture, according to the invention is shown. The system comprises an image acquisition system 1 for generating an optical image 2 of a sample and an evaluation unit 3 for analyzing the image 2 and generating cytometric data.

[0049] The image acquisition system 1 comprises a container 4 containing an optical sample 5 to be analyzed, wherein the container 4 comprises a transparent bottom so that the sample inside the container 4 can be "imaged" by an image sensor 6 from below the container 4 5 for optical analysis, "shadow imaging" as described in Zheng et al. "The ePetri dish, an on-chip cell imaging platform based on subpixel perspective sweeping microscopy (SPSM)" (Proceedings of the National Academy of Sciences (PNAS), 2011) described in. Accordingly, the contents of this publication are hereby incorporated by reference.

[0050] Further, it should be noted that the container 4 compris...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
thicknessaaaaaaaaaa
Login to View More

Abstract

The invention relates to a receptacle (4) for receiving a sample (5) during an optical analysis of the sample (5), wherein the receptacle (4) comprises a bottom (19) which is at least partially transparent so that the sample (5) within the receptacle (4) can be optically analyzed by an image sensor (6) from below the bottom (19) and wherein the bottom (19) is very thin thereby improving contrast and sharpness of the images generated by the image sensor (6). Further, the invention relates to a system for optically analyzing a sample (5).

Description

technical field [0001] The present invention relates to a container for receiving a sample during optical analysis of a sample, such as a biological sample such as a cell culture. Further, the invention relates to a system for optical analysis of a sample, such as a biological sample such as a cell culture. Background technique [0002] The state of the art includes so-called time-lapse microscopy for imaging of living cells. A traditional time-lapse microscopy system includes an optical microscope, digital camera, computer software, and an incubator to control the cellular environment of the sample. However, conventional time-lapse microscopy systems are very expensive and complex. Further, it is difficult to integrate transit-time microscopy systems into a laboratory working environment because transit-time microscopy systems are too bulky and complex for integration into conventional incubators. Finally, clinical applications require the use of conventional time-lapse ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): G01N21/03
CPCG01N21/03G01N33/4833G01N15/1436G01N21/0303G01N21/6458G01N21/6486G01N2021/6471G01N2201/022G01N2201/062G01N2201/068G02B21/16G02B21/361
Inventor 丹尼尔·汉斯·拉波波特蒂姆·贝克尔查理·克鲁泽
Owner FRAUNHOFER GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG EV