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Composite structure microfluidic liquid isolation pumping module

A technology of liquid isolation and composite structure, applied in pumps, pressure pumps, non-volume pumps, etc., can solve problems such as failure to pump, pressure pulsation damage, blockage of flow channels, etc., to reduce redundant volume and waste of test solution, Expand the application field and scope, avoid the effect of mutual pollution

Inactive Publication Date: 2017-01-25
HARBIN INST OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Air bubbles are easy to be generated during the microfluidic pumping process, which not only does not benefit the design function of the microfluidic system, but also causes serious hazards such as blocking the flow channel, changing the flow velocity, pressure pulsation, and destroying the flow stability during operation.
For the problem of air bubbles generated during the pumping process of the non-gas-permeable material module, neither the existing microfluidic active liquid pumping module nor the passive liquid pumping module can rely on their own characteristics to better overcome it
In addition, the existing liquid pumping module cannot realize the pumping of liquid on the closed structure (closed flow channel or chamber) on the non-breathable material layer
Moreover, the existing liquid pumping modules are also difficult to achieve bubble-free, large-scale integrated sequential flow in the non-gas-permeable material layer

Method used

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  • Composite structure microfluidic liquid isolation pumping module
  • Composite structure microfluidic liquid isolation pumping module
  • Composite structure microfluidic liquid isolation pumping module

Examples

Experimental program
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specific Embodiment approach 1

[0011] Specific implementation mode one: as Figure 1~Figure 5 As shown, the composite structure microfluid liquid isolation pumping module, the composite structure microfluid liquid isolation pumping module includes a liquid structure layer 1, a water-repellent gas-permeable layer 2 and a gas structure layer 3; the water-repellent gas-permeable layer 2 Sandwiched between the liquid structure layer 1 and the gas structure layer 3, the water-repellent and gas-permeable layer 2 is sealed with the liquid structure layer 1 and the gas structure layer 3 respectively; the side surface of the liquid structure layer 1 and the water-repellent and gas-permeable layer 2 At least one liquid flow channel is provided, and at least one liquid flow channel sealing chamber 1-2 is formed between the at least one liquid flow channel and a side adjacent to the water-repellent and air-permeable layer 2; The layer 1 is provided with at least one liquid inlet 1-1 in the thickness direction, and the ...

specific Embodiment approach 2

[0022] Specific implementation mode two: as Figure 2~Figure 5 As shown in the specific embodiment 1 of the composite structure microfluidic liquid isolation pumping module, the gas channel sealing chamber 3-2 is distributed around the liquid channel sealing chamber 1-2, or the gas channel sealing The chamber 3-2 is partially overlapped with the liquid channel sealing chamber 1-2. The spatial distribution form between the gas channel sealed chamber 3-2 and the liquid channel sealed chamber 1-2 affects the rate of air diffusion and transport in the liquid structure layer 1 to the gas structure layer 3, indirectly changing the pumping speed of the liquid .

specific Embodiment approach 3

[0023] Specific implementation mode three: as Figure 2~Figure 5 As shown, the water-repellent and air-permeable layer 2 described in the first specific embodiment is made of any material that has air permeability but cannot allow the pumped liquid to penetrate and undergo chemical reactions, such as silica gel or rubber. The material is not limited as long as it meets certain requirements such as air permeability, water repellency, strength, stiffness, and biochemical properties.

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Abstract

The invention relates to a composite-structure microfluid and liquid isolation pumping module and belongs to the technical field of microfluid pumping. A water repellent ventilation layer is clamped between a liquid structure layer and a gas structure layer. A liquid flow channel is formed in one side of the liquid structure layer, which is adjacent to the water repellent ventilation layer. A liquid flow channel seal chamber is formed between one side of the liquid flow channel, which is adjacent to the water repellent ventilation layer. A liquid inlet is formed in the liquid structure layer and is communicated with the external environment and the liquid flow channel seal chamber. A gas flow channel is formed in one side of the gas structure layer, which is adjacent to the water repellent ventilation layer. A gas flow channel seal chamber is formed in one side of the gas flow channel, which is adjacent to the water repellent ventilation layer. A gas transmission port is formed in the liquid structure layer along the liquid structure layer thickness direction and penetrates the water repellent ventilation layer. The gas transmission port is connected with an external negative-pressure gas source, and the gas transmission port is communicated with the gas flow channel seal chamber. By means of the module, non bubble is produced during non-breathable material module pumping, and large-scale integration sequential flow can be achieved.

Description

technical field [0001] The invention relates to a microfluid liquid pumping module, belonging to the technical field of microfluid pumping. Background technique [0002] At present, the liquid sample pumping modules used in related products in the field of microfluidics mainly include active pumping modules driven by external energy and passive pumping modules that rely on their own characteristics such as structural design, surface properties, and material properties for liquid actuation. The active pumping module requires external driving equipment and energy support, and mainly relies on external energy such as pressure energy, electrokinetic energy, and acoustic wave energy to drive the liquid to flow inside the microfluidic system. The passive pumping module mainly includes various driving methods such as capillary drive, degassing drive, gravity drive and evaporation force drive. The module relies on its own characteristics to drive liquid flow spontaneously without ex...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): F04F1/00
CPCF04F1/00
Inventor 刘吉晓符海杨天航李松晶
Owner HARBIN INST OF TECH