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A kind of preparation method of drug-loaded pickering emulsion

An emulsion and drug-loading technology, which is applied in the field of preparation of drug-loaded Pickering emulsions, can solve problems such as sudden release, fast release speed, and obstacles to the application of drug controlled release, so as to achieve the effect of expanding application and improving sustained release performance

Active Publication Date: 2016-08-17
HAINAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, sodium alginate has strong hydrophilicity, large gel pore size, low loading capacity for hydrophobic drugs, fast release rate and easy burst release, which hinders its further application in drug controlled release.

Method used

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  • A kind of preparation method of drug-loaded pickering emulsion
  • A kind of preparation method of drug-loaded pickering emulsion
  • A kind of preparation method of drug-loaded pickering emulsion

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] A kind of preparation method of drug-loaded Pickering emulsion, its method step comprises:

[0035](1) Take 70mL of a mixed solution of formamide and dimethylformamide with a volume ratio of 10:9, weigh 1.0g of p-toluenesulfonic acid, add 2.0g of sodium alginate raw material, and stir evenly at 40°C for 20-40min. Partial protonation; Weigh 0.76g 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride and 0.95g 4-dimethylaminopyridine as the catalytic system of esterification reaction, add Stir 8.0g of lauryl alcohol at 40°C for 20-30 hours, the carboxyl group on the protonated sodium alginate reacts with the hydroxyl group on the lauryl alcohol; the reaction product is precipitated with 4-6 times the volume of ethanol, and the precipitate is taken for high-speed Centrifuge, wash with absolute ethanol, dissolve the precipitate with deionized water, neutralize the product with 1.5% sodium carbonate solution to neutrality; finally dialyze the solution for 4-6 days, fre...

Embodiment 2

[0039] A kind of preparation method of drug-loaded Pickering emulsion, its method step comprises:

[0040] (1) Take 70mL of a mixed solution of formamide and dimethylformamide with a volume ratio of 9:8, weigh 1.0g of p-toluenesulfonic acid, add 1.0g of sodium alginate raw material, and stir evenly at 60°C for 20-40min. Partially protonated; Weigh 0.8g 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride and 1.0g 4-dimethylaminopyridine as the catalyst system for the esterification reaction, add 5.0 g of lauryl alcohol, stirred at 50°C for 20-30h, the carboxyl group on the protonated sodium alginate reacted with the hydroxyl group on the lauryl alcohol; the reaction product was precipitated with 4-6 times the volume of propanol, and the precipitate was taken for high-speed Centrifuge, wash with anhydrous propanol, dissolve the precipitate with deionized water, neutralize the product with 5% sodium bicarbonate to neutrality; finally dialyze the solution for 4-10 days, an...

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Abstract

The invention relates to the technical field of drug controlled release, and in particular relates to a preparation method of a drug-loading Pickering emulsion. A coupling esterification reaction is conduced to produce lauryl alcohol sodium alginate; modified sodium alginate and flake inorganic LDH nanoparticles with positively charged surface are used as emulsifiers; in an aqueous dispersion system, solid particles and anionic polymeric surfactant are closely integrated to form a layer of dense oil / water interfacial film through electrostatic interaction, so as to prepare the stable sustained-release drug-loading Pickering emulsion. A hydrophobic pesticide lambda-cyhalothrin can be embedded in the emulsion droplets to form a drug-store microemulsion small environment, so as to further improve the drug loading amount and release properties of Pickering emulsion on the drug, and expand the application of Pickering emulsion to pesticide drug delivery. The invention has good application prospects in the fields of pesticides and biological medicament transmission.

Description

technical field [0001] The invention belongs to the technical field of drug sustained release and controlled release, and in particular relates to a preparation method of drug-loaded Pickering emulsion. Background technique [0002] In recent years, due to the important applications of Pickering emulsions in the fields of controlled drug release and synthesis of micro / nano materials, researchers at home and abroad have paid increasing attention. Layered double hydroxide (LDH) is a flake nanoparticle with a hydrotalcite-like structure. Because its surface contains a certain amount of charge, the electrostatic repulsion between particles in the emulsion is relatively large, which reduces the coalescence of the emulsion. Stability, thereby limiting its application in drug sustained release. These inorganic solid particles are used as emulsifiers to prepare stable Pickering emulsions. Adding an appropriate amount of surfactant to adsorb on the surface of the particles can effec...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A01N25/18A01N25/04A01N53/08A01P7/04A01P7/02
Inventor 李嘉诚冯玉红林强刘若林魏思宝颜慧琼
Owner HAINAN UNIV