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A kind of effective part of traditional Chinese medicine for treating coronary heart disease and hyperlipidemia, preparation method and method for separating effective components therefrom
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A technology of effective parts and hyperlipidemia, applied in the field of medicine, can solve problems such as unreported
Active Publication Date: 2017-04-05
GUILIN EIGHT PLUS ONE PHARMA CO LTD
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Embodiment 1
[0025] ⑴. Remove sediment and fibrous roots from the rhizomes of turmeric, wash them, slice them, and dry them in the sun to make medicinal parts;
[0026] (2) Take 1800g of rhizome decoction pieces of turmeric, add 6 times the amount of 80% ethanol to reflux twice, combine the two extracts, filter, recover ethanol from the filtrate, concentrate under reduced pressure to a relative density of about 1.10 (45°C) , to get the crude extract of curcuma tomentosa;
[0027] (3) The crude extract was extracted 6 times with 2 times the amount of water-saturated n-butanol, the n-butanol extracts were combined, the n-butanol was recovered under reduced pressure, concentrated, and vacuum-dried to obtain 121 g of effective fractions.
Embodiment 2
[0029] ⑴. Remove sediment and fibrous roots from the rhizomes of turmeric, wash them, slice them, and dry them in the sun to make medicinal parts;
[0030] (2) Take 2000g of rhizome decoction slices of turmeric, add 6 times the amount of 75% ethanol to reflux twice, combine the two extracts, filter, recover ethanol from the filtrate, concentrate under reduced pressure to a relative density of 1.05-1.10 (45°C ) to get the crude extract of Curcuma officinalis;
[0031] (3) The crude extract was extracted 6 times with 3 times the amount of ethyl acetate, the ethyl acetate extracts were combined, the ethyl acetate was recovered under reduced pressure, concentrated, and vacuum-dried to obtain 116 g of the effective fraction.
Embodiment 3
[0033] ⑴. Remove sediment and fibrous roots from the rhizomes of turmeric, wash them, slice them, and dry them in the sun to make medicinal parts;
[0034] (2) Take 2000g of rhizome decoction slices of turmeric, add 6 times the amount of 75% ethanol to reflux twice, combine the two extracts, filter, recover ethanol from the filtrate, concentrate under reduced pressure to a relative density of 1.05-1.10 (45°C ) to get the crude extract of Curcuma officinalis;
[0035] (3) The crude extract was extracted with 3 times the amount of mixed solvent composed of petroleumether: ethyl acetate (volume ratio of 3 to 20:1), extracted 6 times, combined with petroleumether: ethyl acetate extract, and decompressed The solvent was recovered, concentrated, and vacuum-dried to obtain 105 g of effective fraction.
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Abstract
The invention belongs to the field of medicine technology, and particularly relates to a traditional Chinese medicine effective fraction for treating coronary heart disease and hyperlipidemia, and a preparation method thereof, and a method for separating effective components from the traditional Chinese medicine effective fraction. According to the present invention, the traditional Chinese medicine effective fraction adopts the dried rhizome of a Curcuma longa plantCurcuma aromatica as a medicinal position, the medicinal position is subjected to organic solvent extraction, the extract is separated and purified to obtain the effective fraction containing the sesquiterpene component, and the sesquiterpene content in the effective fraction is more than 50%; and pharmacological experiment research results show that: curcumadiol, procurcumenol, curdione, zedoarondiol and the total extract provide significant myocardial ischemia treatment effects, can significantly reduce the ischemia-induced rat myocardial injury and myocardial infarction area range, and provide significant protection effects for rat myocardial ischemia and injury with coronary arteryligation.
Description
technical field [0001] The invention belongs to the field of medical science and technology, and in particular relates to an effective part of a traditional Chinese medicine extracted from the rhizome of Curcumacurcuma for treating coronary heart disease and hyperlipidemia, a preparation method thereof and a method for isolating active ingredients therefrom. Background technique [0002] Heart disease, malignant tumor, and cerebrovascular disease are three diseases that seriously threaten human life today. Since the 1990s, coronary heart disease has ranked first in my country's health killer list. With the rapid development of my country's economy, people's living standards continue to improve With the huge changes in life style and diet structure, the incidence of coronary heart disease in my country is on the rise. Coronary heart disease is the most common heart disease, which refers to myocardial dysfunction and organic disease caused by coronary arterystenosis and insuf...
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