Device used for preparing ultrasmall superparamagnetic iron oxide (USPIO) nano particles via high-voltage electrostatic helix driven

Abstract

The invention discloses a device used for preparing ultrasmall superparamagnetic iron oxide (USPIO) nano particles via high-voltage electrostatic helix driven, and belongs to the technical field of medical imaging. The device is composed of an electromagnetic stirrer (1), a particle preparing barrel (2), a high voltage electrostatic particle classifier (3), a particle collecting tank (4), a stirring rod (7), and a tapered material saving wall (8); the tapered material saving wall (8) made of glass is arranged on the lower part of the particle preparing barrel (2); 3 to 10 discharge holes (22) are arranged on the upper part wall of the particle preparing barrel (6) successively from top to bottom; a fixed magnetic body (30) and a movable magnetic body (35) of the high voltage electrostatic particle classifier (3) are cuboid in shape, and length ranges from 0.2 to 0.5cm, width ranges from 0.15 to 0.45cm, and thickness ranges from 2 to 4cm. The device used for preparing ultrasmall superparamagnetic iron oxide (USPIO) nano particles via high-voltage electrostatic helix driven is simple for preparation, and is high in operationality, low in cost, and excellent in effect.

Description

technical field [0001] The invention relates to a device for preparing ultrafine superparamagnetic iron oxide nanoparticles by high-voltage electrostatic spiral traction, and belongs to the technical field of medical imaging. Background technique [0002] At present, chemotherapy drugs combined with traditional Chinese medicine are commonly used in clinical treatment of cancer, especially pancreatic cancer. There are many therapeutic drugs and treatment options, but it is not yet possible to effectively evaluate the efficacy of drugs at the molecular imaging level. In recent years, molecular imaging has become a new direction for the diagnosis and treatment of pancreatic cancer, and its application is becoming more and more extensive. Among them, magnetic resonance molecular imaging based on ultrafine superparamagnetic iron oxide particles (USPIO) is a research direction with great potential. USPIO is a high-efficiency solid tumor MRI contrast agent. It has the ability to di...

AI Technical Summary

Problems solved by technology

[0003] In order to overcome the problems that the known method of preparing ultrafine superparamagnetic iron oxide nanoparticles takes a long time, the operator needs to wait for 24 hours, and the steps are cumbersome, often resulting in large waste and difficult operation, the present invention provides a high-voltage electrostatic The device for preparing ultrafine superparamagnetic iron oxide nanoparticles by spiral traction, this kind of high-voltage electrostatic spiral traction device for preparing ultrafine superparamagnetic iron oxide nanoparticles uses the electromagnetic force stirrer to drive the stirring rod to rotate, and the magnetic The fluid rotates due to the agitation of the stirring rod. After reaching a certain speed, the liquid level of the magnetic fluid in the particle preparation barrel will gradually increase, and then the particles with different diameters will be separated gradually due to the difference in weight. The surface distance is long, and the particles with large diameter and weight are close to the raw liquid surface. Then, the high-voltage electrostatic particle sorter is turned on, and the particles with different distances enter the outlets at different heights to be sorted out, thereby avoiding Save time by using dialysis membranes for prolonged dialysis

Images