Sulfo group-containing spirooxazine type photochromic compound as well as preparation method and application thereof
A technology containing sulfonic spirooxazine and photochromism, which is applied in chemical instruments and methods, color-changing fluorescent materials, organic chemistry, etc., can solve the problems of unsatisfactory light fastness and achieve the effect of simple synthesis process
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Embodiment 1
[0051] The preparation of embodiment 1 compound 1
[0052] The reaction formula is as follows:
[0053]
[0054] Dissolve 3.2g (20.2mmol) of 1,3,3-trimethyl-2-methylene indoline in 10ml of 98% concentrated sulfuric acid, and add 6.5g of 30 % oleum, after adding the oleum dropwise, keep warm for 5 hours at 0-5°C. After the reaction, add the reaction liquid dropwise to 200ml of water to dilute, a large amount of solids precipitate out, filter, wash with water, and dry to obtain 4.96g of 5-sulfonic acid-1,3,3-trimethyl-2-methylene Indoline, the yield is 97%, and the melting point is 265°C.
[0055] Under the protection of nitrogen, add 2.5g (14.4mmol) 1-nitroso-2-naphthol, 3.6g (50.5mmol) tetrahydropyrrole to the flask, then add absolute ethanol until completely dissolved, stir under microwave pressure 25 volts, electric current 200 milliampere heating reaction for 20 minutes, stop the reaction, cool, remove excess tetrahydropyrrole by distillation under reduced pressure to...
Embodiment 2
[0059] The preparation of embodiment 2 compound 2
[0060] The reaction formula is as follows:
[0061]
[0062] Dissolve 6.0g (30mmol) of 1-isopropyl-3,3-dimethyl-2-methyleneindoline in 15ml of 98% concentrated sulfuric acid, drop it into the reaction solution at 0-5°C Add 14.4g of 20% fuming sulfuric acid, after the addition of fuming sulfuric acid is completed dropwise, keep the reaction at 0-5°C for 6 hours. After the reaction, add the reaction feed solution dropwise to 150ml of water to dilute, a large amount of solids precipitate out, filter, wash with water, and dry to obtain 8.26g of 5-sulfonic acid-1-isopropyl-3,3-dimethyl- 2-Methyleneindoline, the yield is 98%.
[0063] Under the protection of nitrogen, add 2.5g (14.4mmol) 1-nitroso-2-naphthol, 6.9g (57.6mmol) indoline to the flask, then add absolute ethanol until completely dissolved, stir under microwave pressure 30 volts, electric current 220 milliamperes heating reaction 25 minutes, stop reaction, cooling, ...
Embodiment 3
[0067] The preparation of embodiment 3 compound 3
[0068] The reaction formula is as follows:
[0069]
[0070] Dissolve 4.3g (20mmol) of 1-isobutyl-3,3-dimethyl-2-methylene indoline in 20ml of 98% concentrated sulfuric acid, drop it into the reaction solution at 0-5°C Add 6.9g of 30% fuming sulfuric acid, after the addition of fuming sulfuric acid is completed dropwise, keep warm for 5 hours at 0-5°C. After the reaction, add the reaction feed solution dropwise to 100ml of water for dilution, a large amount of solids precipitate out, filter, wash with water, and dry to obtain 5.7g of 5-sulfonic acid-1-isobutyl-3,3-dimethyl- 2-Methyleneindoline, the yield is 96.6%.
[0071] Under the protection of nitrogen, add 2.5g (14.4mmol) 1-nitroso-2-naphthol, 5.0g (57.6mmol) morpholine to the flask, then add absolute ethanol until completely dissolved, stir under microwave pressure 40 Volt, electric current 240 milliampere heating reaction 15 minutes, stop reaction, cooling, underp...
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