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Traditional Chinese medicine composition resistant to pathogenic microorganisms and preparation method and application of traditional Chinese medicine composition

An anti-pathogenic microorganism and composition technology, which is applied in the directions of antibacterial drugs, pharmaceutical formulations, active ingredients of hydroxyl compounds, etc., can solve problems such as the concentration limit of Coptis chinensis crude drug, and achieve the effects of good clinical application prospects, low cost and remarkable curative effect.

Active Publication Date: 2015-09-30
张军
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But as mentioned earlier, the improvement of the concentration of Coptidis crude drugs is limited by conventional dosage forms

Method used

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  • Traditional Chinese medicine composition resistant to pathogenic microorganisms and preparation method and application of traditional Chinese medicine composition
  • Traditional Chinese medicine composition resistant to pathogenic microorganisms and preparation method and application of traditional Chinese medicine composition
  • Traditional Chinese medicine composition resistant to pathogenic microorganisms and preparation method and application of traditional Chinese medicine composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] The Chinese medicine composition of embodiment 1 antipathogenic microorganisms

[0046] A traditional Chinese medicine composition for resisting pathogenic microorganisms, the active ingredients of the Chinese medicine composition are prepared from the following raw materials in parts by weight: 25 parts of Coptis chinensis, 3 parts of Gentiana, 4 parts of Baibu, 4 parts of Sophora flavescens, 1.5 parts of cloves 4.5 parts of fenugreek, 13.5 parts of Sanbaicao, 7 parts of Daqingye, 5.5 parts of cockscomb, and 1.5 parts of borneol.

[0047] The preparation method of this Chinese medicine composition is as follows:

[0048] (1) Take Coptidis Rhizoma, Gentiana, Radix Potatoes, Sophora Sophorae, Sanbaicao, Folium Folium, and Cockscomb according to the prescription ratio, grind them into medium powder, moisten with a small amount of 80% ethanol solution, and seal them for 30 minutes. Put it into a percolation device, soak it with a small amount of 80% ethanol solution for 2...

Embodiment 2

[0051] The anti-CA drug susceptibility test of the Chinese medicine composition of embodiment 2 antipathogenic microorganisms

[0052] 1 Test materials (instruments, reagents, medicinal materials and test bacteria)

[0053] Rotary evaporator (ELELA SB-1000);

[0054] Sleeve thermostat (TC-15, Haining Xinhua Medical Instrument Factory);

[0055] CNC ultrasonic cleaner (KQ5200DA, Kunshan Ultrasonic Equipment Co., Ltd.);

[0056] Single-person double-sided purification workbench (Suzhou Purification Equipment Co., Ltd.);

[0057] High-pressure steam sterilizer (Shanghai Sanshen Medical Instrument Co., Ltd.);

[0058] Constant temperature incubator (Ikemoto Physical and Chemical Industry Co., Ltd.);

[0059] Air bath oscillator (Harbin Donglian Electronic Technology Development Co., Ltd.);

[0060] Sabouraud liquid medium (Qingdao Hi-tech Park Haibo Biotechnology, batch number: 20120822);

[0061] Sabouraud agar medium (Qingdao High-tech Park Haibo Biotechnology, batch numbe...

Embodiment 3

[0095] The anti-CA susceptibility test of the anti-pathogenic microorganism traditional Chinese medicine composition obtained by different extraction methods of embodiment 3

[0096] 3.1 Prescription Composition

[0097] The composition and proportioning of the prescription raw materials of the anti-pathogenic microorganism traditional Chinese medicine composition described in this embodiment are the same as those in Example 1.

[0098] 3.2 Test material

[0099] The description of the test materials used in this embodiment is the same as that in Embodiment 2.

[0100] 3.3 Preparation of test solution

[0101] 3.3.1 Quanfangshui provides the preparation of the test solution

[0102] Weigh the whole medicinal material according to the prescription ratio, decoct it with water for 2 times, the amount of water added is 10 times and 8 times of the weight of the medicinal material respectively, the decoction time is 1.5 hours and 1 hour respectively, combine the two decoctions, d...

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Abstract

The invention relates to a traditional Chinese medicine composition resistant to pathogenic microorganisms and a preparation method and application of the traditional Chinese medicine composition and belongs to the technical field of traditional Chinese medicine. The active ingredients of the traditional Chinese medicine composition are prepared from the following raw materials comprising, by weight, 20-40 parts of rhizome of Chinese goldthread, 2-4 parts of gentians, 3-6 parts of radix stemonae, 3-6 parts of sophora flavescens, 1-3 parts of cloves, 3-6 parts of Chinese mosla herb, 10-20 parts of saururus chinensis, 5-10 parts of folium isatidis, 4-8 parts of cockscombs and 1-3 parts of borneol. The rhizome of Chinese goldthread is mainly used in the traditional Chinese medicine composition, has an inhibition effect on various pathogenic microorganisms, and has a remarkable antibacterial effect on candida albicans, staphylococcus aureus and beriberi pathogenic bacteria. The traditional Chinese medicine composition is prepared into thixotropic gels, the preparation method is simple and novel, the drug loading capacity of the prepared traditional Chinese medicine composition is large, and the curative effect is good.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine, and in particular relates to a traditional Chinese medicine composition for resisting pathogenic microorganisms, a preparation method and application thereof. Background technique [0002] Vulvovaginal Candidiasis (VVC for short), also known as mycotic vaginitis, is a reproductive tract infectious disease caused by Candida Albicans (abbreviated as CA), second only to bacterial vaginosis, mainly Occurring in women of childbearing age, it is a common and frequently-occurring disease in gynecology, affecting the health and normal life of most women. About 75% of women have at least one episode of candidal vaginitis in their lifetime, and 40% to 50% of them will have repeated episodes. [0003] Western medicine clinical treatment of the disease often adopts different antifungal drugs and treatment schemes, including azole drugs and polyene drugs, and the main varieties of azole ...

Claims

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Application Information

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IPC IPC(8): A61K36/904A61K9/06A61K47/38A61P31/10A61P31/04A61K31/045
Inventor 张军林丽梁土亮刘磐
Owner 张军
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