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Suaeglaucin and preparation method therefor and use thereof

The technology of Suaeda flavonoids and Suaeda salsa is applied in the field of medical technology and can solve the problems of less research on chemical components and the like

Active Publication Date: 2015-11-04
INST OF BOTANY JIANGSU PROVINCE & CHINESE ACADEMY OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Studies have shown that Suaeda salsa is rich in nutrients, and the fat content of Suaeda salsa seeds is relatively high, accounting for about 36.5% of its dry matter, which is higher than that of soybeans; the protein content of fresh and tender stems and leaves of Suaeda salsa is 40%; in addition to the above nutrients , Suaeda salsa also contains rich vitamins and trace elements necessary for human beings. Suaeda salsa contains a large amount of flavonoids, but there are few studies on its chemical composition

Method used

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  • Suaeglaucin and preparation method therefor and use thereof
  • Suaeglaucin and preparation method therefor and use thereof
  • Suaeglaucin and preparation method therefor and use thereof

Examples

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Effect test

Embodiment 1

[0018] Example 1. Isolation and identification of the new compound from the whole herb of Suaeda salsa

[0019] About 10 Kg of the dried whole herb of Suaeda salsa is crushed, heated and refluxed with 80% ethanol for 3 times, concentrated to obtain the total extract, which is extracted 3 times with petroleum ether, ethyl acetate and n-butanol in sequence to obtain ethyl acetate 180 g of extract from the site was subjected to silica gel column chromatography, petroleum ether-ethyl acetate-methanol gradient elution, a total of 11 fractions were collected, and fraction 6 was repeatedly subjected to silica gel column, Sephadex LH-20 column, reversed-phase column chromatography The monomer compound was obtained from the ethanol extract of dried whole herb of Suaeda salsa, and was identified as Suaeda flavonoid B by physical and chemical properties and spectral methods, and the compound was a new compound through literature search.

[0020] The structure of the compound is identif...

Embodiment 2

[0031] Immunosuppressive activity assay

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Abstract

The invention relates to the technical field of medicines and discloses suaeglaucin and a preparation method therefor and use thereof. The compound has immunosuppressive activity, and the chemical name is 7,2'-dihydroxy-5,6-dimethoxyisoflavone and the structural formula is a formula shown in the description. The invention further relates to the preparation method of the compound and an influence of the compound on immunoproliferation effect induced by LPS and ConA. Search results find that suaeglaucin has good immunosuppressive activity and can be used for preparing drugs for treating immune diseases.

Description

technical field [0001] The invention relates to the field of medical technology, and is a new compound for treating immunity-related diseases—Suaeda flavone B, chemical name: 7,2'-dihydroxy-5,6-dimethoxy-isoflavone (7 , 2′-dihydroxy-5,6-dimethoxyiso?avone) and its use in the field of medicine for treating immunocompromised diseases. It specifically relates to a new compound isolated from the ethanol extract of Suaeda salsa, which has significant inhibitory activity on lipopolysaccharide-induced B lymphocyte proliferation and ConA-induced T lymphocyte proliferation. The results of the study found that Suaeda salsa Flavonoid B has very good immunosuppressive activity. Background technique [0002] Suaeda salsa Suaeda glauca (Bunge) Bunge is Chenopodiaceae Suaeda genus Suaeda Forsk. ex Scop. Annual herbaceous eusalt plant. It is widely distributed in saline-alkali deserts and coastal tidal flats in Xinjiang, Shandong, Hebei, Liaoning, Jilin, Inner Mongolia and Gansu. Natu...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D311/36C07D311/40A61K31/352A61P37/04
CPCC07D311/36C07D311/40
Inventor 王奇志邱萍冯煦单宇管福琴刘飞陈雨印敏赵兴增赵友谊王鸣张建华
Owner INST OF BOTANY JIANGSU PROVINCE & CHINESE ACADEMY OF SCI