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Method for hydrolyzing 5-(2- methylthioethyl)-hydantoin

A technology of methylthioethyl and hydantoin, applied in the field of chemical industry, can solve the problems of dark methionine product, high consumption, unsatisfactory barium sulfate methionine yield, etc. Product, the effect of improving yield

Inactive Publication Date: 2015-11-11
NINGXIA UNISPLENDOUR TIANHUA METHIONINE CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, this process consumes a large amount of expensive barium hydroxide, and the final by-product of low-value barium sulfate and the yield of methionine are not ideal, and the obtained methionine product has a darker color

Method used

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  • Method for hydrolyzing 5-(2- methylthioethyl)-hydantoin

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] 500 grams of 5-(methylthioethyl)-hydantoin (0.3856 mole) aqueous solution (5-(methylthioethyl)-hydantoin content is 13.42wt%, sodium carbonate content is 4.10wt%) %), 16.1 grams of 96% sodium hydroxide (0.386 mole) and 210 g of 25% ammoniacal liquor (3.08 mole) are added in the autoclave of 1000 ml, and the airtight reactor is heated up to 180 ° C immediately, kept stirring for 15 minutes, and then cooled to room temperature (18-25°C), and the pressure was released to normal pressure (100KPa) to obtain a pale yellow liquid with a pH of 10.8. After detection by high performance liquid chromatography, the yield of methionine is 99.5%, and the yield of methionine dipeptide (N-methionyl-methionine) is 0.56%.

Embodiment 2

[0028]500 grams of 5-(methylthioethyl)-hydantoin (0.3856 mole) aqueous solution (5-(methylthioethyl)-hydantoin content is 13.42wt%, sodium carbonate content is 4.10wt%) %) and 273g of 60% ammonia (9.64 moles) were added to a 1000ml autoclave, the autoclave was closed, the temperature was raised to 190°C immediately, the temperature was kept and stirred for 25 minutes, then cooled to room temperature (18-25°C), and the pressure was released to normal pressure (100KPa) to obtain a pale yellow liquid with a pH of 10.5. After detection by high performance liquid chromatography, the yield of methionine is 97%, and the yield of methionine dipeptide (N-methionyl-methionine) is 5%.

Embodiment 3

[0032] 500 grams of 5-(methylthioethyl)-hydantoin (0.3856 mole) aqueous solution (5-(methylthioethyl)-hydantoin content is 13.42wt%, sodium carbonate content is 4.10wt%) %), 8.03 gram of 96% sodium hydroxide (0.193 mole) and 218.5g of 60% ammoniacal liquor (7.7 mole) add in the autoclave of 1000ml, airtight reactor, be warming up to 190 ℃ immediately, insulated and stirred for 15 minutes, then Cool to room temperature (18-25°C), release the pressure to normal pressure (100KPa) to obtain a light yellow liquid with a pH of 10.6. After detection by high performance liquid chromatography, the yield of methionine is 97%, and the yield of methionine dipeptide (N-methionyl-methionine) is 4%.

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Abstract

The invention discloses a method for hydrolyzing 5-(2- methylthioethyl)-hydantoin. The method comprises the following steps: sufficiently hydrolyzing a 5-(2- methylthioethyl)-hydantoin aqueous solution or a 5-(2- methylthioethyl)-hydantoin aqueous solution containing carbonate or hydrocarbonate in an inorganic alkaline solution which at least contains ammonia or ammonium hydroxide at a temperature of 160-200 DEG C and a pressure of 0.5-4.5MPa; and acidifying the hydrolyzed solution to prepare methionine. According to the method, the usage of alkali can be reduced, byproducts can be greatly reduced, and ammonia is not consumed in the whole process and can be recycled by a simple method. The method can be used for realizing continuous production, and can be used for industrial large-scale production of methionine salt or methionine.

Description

technical field [0001] The invention belongs to the field of chemical industry, in particular to a method for hydrolyzing 5-(2-methylthioethyl)-hydantoin. Background technique [0002] D, L-methionine, also known as methionine, is one of the basic units of protein. It is the only amino acid containing sulfur among the essential amino acids. In addition to participating in the transfer of methyl groups in animals, phosphorus metabolism and adrenaline, choline, In addition to the synthesis of creatine, it is also a raw material for the synthesis of protein and cystine. Methionine is widely used in the fields of medicine, food, feed and cosmetics, among which it is used in a large amount as a feed additive. The global demand for methionine has reached 1.6 million tons per year, and the demand for methionine in China in 2015 exceeded 140,000 tons. At present, in addition to the 110,000 tons of methionine produced by Chongqing Ziguang Chemical Industry Co., Ltd., my country also ...

Claims

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Application Information

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IPC IPC(8): C07C323/58C07C319/20
Inventor 吴传隆韦异勇王用贵李欧耿明刚覃玉芳金海琴
Owner NINGXIA UNISPLENDOUR TIANHUA METHIONINE CO LTD
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