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A kind of hypoglycemic composition and its application

A composition and technology for lowering blood sugar, applied in the directions of drug combination, active ingredients of heavy metal compounds, confectionery, etc., can solve the problems of increased cost, increased sensitivity of pancreatic islet receptors, unsatisfactory therapeutic effect of ingredients, etc., and achieve the effect of improving effect

Active Publication Date: 2019-04-16
张丽
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Chinese Patent Authorization Announcement No. CN102860451 B discloses taking chitosan oligosaccharide and L-arabinose in combination, while using chitosan oligosaccharide to promote human insulin secretion, increase the sensitivity of islet receptors, and enhance blood sugar utilization, taking L-arabinose to inhibit The absorption of sucrose by the human body reduces the production and absorption of glucose, thus through two-way regulation, but its hypoglycemic effect is still unsatisfactory
It is obviously impossible to use 210±3.7g mice in the hypoglycemic experiment in the patent description, and the weight of the mice cannot reach 210g, which only shows that the hypoglycemic effect is not obvious, and the recommended dosage for adults is 10.2g / day , the dose is very large, it is not suitable for marketing, and other raw materials such as taurine and wolfberry extract are added, which increases the cost
[0007] Therefore, the therapeutic effect of the above ingredients is still not ideal

Method used

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  • A kind of hypoglycemic composition and its application
  • A kind of hypoglycemic composition and its application
  • A kind of hypoglycemic composition and its application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] Raw materials: 3340g of L-arabinose, 660g of chitosan oligosaccharide, 160g of chromium-enriched yeast (containing 0.32g of trivalent chromium), accessories: 340g of starch

[0043] Crush the L-arabinose and pass through a 80-mesh sieve; the chitosan oligosaccharide, chromium-enriched yeast, and starch are respectively passed through a 80-mesh sieve for later use. Mix the chromium-rich yeast and chitosan oligosaccharide uniformly first, and then mix them with L-arabinose and starch in a mixer for 30 minutes to obtain a mixed powder for later use. Add 80% ethanol to the above mixed powder and stir to make soft material, granulate with 20 mesh, dry at 50-60°C, granulate with 20 mesh to obtain granules. The granule is filled, 0.45g / granule, and the obtained capsules are polished and screened to remove unqualified products to obtain qualified capsules.

Embodiment 2

[0045] Raw material: 5010g of L-arabinose, 990g of chitosan oligosaccharide, 240g of chromium-enriched yeast (containing 0.48g of trivalent chromium), excipients: 3760g of mannitol.

[0046] Grind L-arabinose and pass through a 80-mesh sieve; oligochitosan, chromium-enriched yeast, and mannitol are respectively passed through a 80-mesh sieve for later use. Mix chromium-rich yeast and chitosan oligosaccharide uniformly first, and then mix them with L-arabinose and mannitol in a mixer for 30 minutes to obtain a mixed powder for later use. Divide the mixed powder into 2g / bag. Instantly.

Embodiment 3

[0048] Raw material: 2400g of L-arabinose, 480g of chitooligosaccharide, 120g of chromium-enriched yeast (containing 0.24g of trivalent chromium), 1752g of mannitol, excipients: 48g of magnesium stearate.

[0049] The L-arabinose is pulverized and passed through a 80-mesh sieve; the chitosan oligosaccharide, chromium-enriched yeast, mannitol, and magnesium stearate are respectively passed through an 80-mesh sieve. Mix the chromium-rich yeast and chitosan oligosaccharide evenly first, then mix them with L-arabinose and mannitol in a mixer for 30 minutes to obtain a mixed powder, add 30% ethanol to the above mixed powder and stir to make a soft material, 20 mesh Granules, dried at 40-50°C to a moisture content of 3.0-5.0%, granulated with 24 mesh to obtain dry granules. Put the dry granules and magnesium stearate into a mixer and mix for 10 minutes, and mix evenly to obtain the total blend granules. The granules are mixed together and compressed into tablets, 1g / tablet, to obta...

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Abstract

The present invention provides a hypoglycemic composition and application thereof. The composition provided by the invention comprises L-arabinose, chitosan oligosaccharide, trivalent chromium and accessories. The composition of the present invention has significantly improved effect of treating diabetes better than any two of the individual usage of L-arabinose, chitosan oligosaccharide and trivalent chromium. The composition provided by the present invention is applicable to the preparation of food, medicines and health care products, and can be used for the treatment or prevention of hyperglycemia.

Description

technical field [0001] The invention relates to a blood sugar composition and its application. It specifically relates to a composition comprising L-arabinose, chitosan oligosaccharide and trivalent chromium and its application in preventing and treating hyperglycemia. technical background [0002] Diabetes mellitus is a common chronic metabolic disease, clinically characterized by elevated blood sugar, typical cases can be seen with polydipsia, polyphagia, polyuria, emaciation and other three more than one less symptoms. With the improvement of people's living standards and the progress of the aging trend of society, the incidence of diabetes is getting higher and higher. [0003] The main methods for treating diabetes are: ① promote insulin synthesis and secretion, the mechanism of action of this type of drug is to directly stimulate the secretion of insulin by pancreatic β cells to lower blood sugar; ② promote the effect of peripheral tissues (such as muscle, etc.) on gl...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K33/00A61K36/064A61K31/722A61P3/10A23L33/00A23G3/36A61K31/7004A61K31/28A61K31/555
Inventor 张丽
Owner 张丽
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