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Blood lipid lowering Chinese medicinal composition, preparation and preparation technology thereof

A composition and technology of traditional Chinese medicine, applied in the field of blood lipid-lowering traditional Chinese medicine composition and its preparation and preparation, can solve the problems of low drug solubility, slow disintegration of effervescent tablets, affecting the stability of preparations, etc., and achieve the effect of good taste

Active Publication Date: 2015-11-18
ZHUHAI UNITED LAB
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Effervescent preparations of traditional Chinese medicines are rarely developed, which may be due to the difficult problems in the industrialization process of such preparations, including but not limited to: sticking problems, stability problems, disintegration problems, etc.; first , the ambient humidity is too high, the material has a high water content or becomes sticky when wet (such as sugar, citric acid, etc.), the heat generated by the friction between the punch and the die during tableting softens the material, and improper selection of lubricants can cause stickiness. The flushing phenomenon affects the industrialization and production efficiency of effervescent tablets; secondly, the acid source and alkali source can undergo acid-base reaction in the presence of trace water, and then generate bubbles and water to make the reaction continue
After the effervescent tablet absorbs moisture and deteriorates, it not only affects the appearance and disintegration performance, but also seriously affects the stability of the preparation; thirdly, the viscosity of the drug is high, it is difficult for water to penetrate into the tablet core, the solubility of the drug is low, the hardness of the prepared granules is too large, and the excipients Improper selection and other reasons can lead to slow disintegration of effervescent tablets

Method used

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  • Blood lipid lowering Chinese medicinal composition, preparation and preparation technology thereof
  • Blood lipid lowering Chinese medicinal composition, preparation and preparation technology thereof
  • Blood lipid lowering Chinese medicinal composition, preparation and preparation technology thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Example 1: Extraction of Salvia miltiorrhiza, red peony root, hawthorn, ginkgo biloba and Panax notoginseng

[0038] Salvia miltiorrhiza 1500g, red peony root 750g, hawthorn 190g, 3 Chinese herbal medicines were washed, cut into pieces, placed in a multi-functional extraction tank, decocted and extracted three times with about 8 times the amount of pure water, each time for 2 to 5 hours; combined filtrates, Pass through a 200-mesh sieve; the filtrate is concentrated under reduced pressure to a thick paste with a relative density of 1.10-1.30.

[0039] The thick paste was spray-dried (inlet temperature: 150°C; outlet temperature: 90°C), the collected medicinal powder was sieved through a 100-mesh sieve, and the obtained extract was sealed and stored to obtain 732 g of Salvia miltiorrhiza, red peony root and hawthorn extracts.

[0040] Ginkgo biloba extract: take fresh ginkgo leaves 350Kg , washed, dried, dried in an oven at 70 °C for 9 hours (the time depends on the moi...

Embodiment 2

[0043] Example 2: Preparation of Chinese Medicine Effervescent Tablets

[0044]

[0045] Preparation:

[0046] sieve

[0047] Ginkgo biloba extract and Panax notoginseng extract were passed through a 100-mesh sieve and set aside.

[0048] Anhydrous citric acid, sodium bicarbonate, lactose, fructose, aspartame, and magnesium stearate are passed through an 80-mesh sieve and set aside.

[0049] mix

[0050] Put the extracts of Salvia miltiorrhiza, red peony root, and hawthorn together with the above-mentioned sieved raw materials in a mixer, and mix at a speed of 8 rpm for 30 minutes, and set aside.

[0051] film

[0052] The mixed material was compressed into 3.0 g round tablets by a tablet machine.

[0053] Package

[0054] Compressed into tablets, the packaging machine automatically enters the packaging process.

Embodiment 3

[0055] Example 3: Preparation of Chinese Medicine Effervescent Tablets

[0056]

[0057] Preparation:

[0058] sieve

[0059] Ginkgo biloba extract and Panax notoginseng extract were passed through a 100-mesh sieve and set aside.

[0060] Anhydrous citric acid, sodium bicarbonate, lactose, fructose, aspartame, and magnesium stearate are passed through an 80-mesh sieve and set aside.

[0061] mix

[0062] Put the extracts of Salvia miltiorrhiza, red peony root, and hawthorn together with the above-mentioned sieved raw materials in a mixer, and mix at a speed of 8 rpm for 30 minutes, and set aside.

[0063] Chip

[0064] The mixed material was compressed into 3.0 g round tablets by a tablet machine.

[0065] Package

[0066] Compressed into tablets, the packaging machine automatically enters the packaging process.

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Abstract

Relating to the field of medicine, the invention in particular provides a blood lipid lowering Chinese medicinal composition, a preparation and a preparation technology thereof. The Chinese medicinal composition provided by the invention comprises, by weight part, 133-174 of Salvia Miltiorrhiza, 67-87 of Radix Paeoniae Rubra, 17-22 of hawthorn, 400-733 of ginkgo leaf, and 24-54 of Panax notoginseng. The invention also provides an effervescent tablet preparation containing the Chinese medicinal composition. The Chinese medicinal composition provided by the invention has significant blood lipid lowering effect, is especially suitable for high blood lipid patients. And the effervescent tablet has the characteristics of rapid disintegration, good taste, easy carrying, and convenient use. Also, the preparation process has the advantages of simplicity, convenient operation, good compressibility, and continuous tabletting without sticking and picking.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, relates to a traditional Chinese medicine composition and its preparation and preparation method, in particular to a blood lipid-lowering traditional Chinese medicine composition and its preparation and preparation process. Background technique [0002] With the continuous improvement of people's living standards, eating well and exercising less, blood lipids are high. At present, patients with hyperlipidemia are extremely common, including hypercholesterolemia, hypertriglyceridemia and complex hyperlipidemia, which is one of the main factors leading to atherosclerosis and coronary heart disease. It also has a non-negligible effect on kidneys, peripheral circulation, pancreas, pruritus, immune system, and blood system diseases. For people with high incidence of such diseases, those skilled in the art are constantly developing new drugs or health food to improve people's blood...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/734A61K9/46A61P3/06
Inventor 杜青波张水添王德刚朱美容
Owner ZHUHAI UNITED LAB
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